Zobrazeno 101 - 110
of 116
pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Marc Schmidt, Rob Klompmaker, René H. Medema, Armando van der Horst, Boudewijn M.T. Burgering, Sylvia Fernandez de Mattos, Eric Lam, Geert J. P. L. Kops
Publikováno v:
Molecular and cellular biology, 22(22), 7842. American society for microbiology
The FoxO forkhead transcription factors FoxO4 (AFX), FoxO3a (FKHR.L1), and FoxO1a (FKHR) represent important physiological targets of phosphatidylinositol-3 kinase (PI3K)/protein kinase B (PKB) signaling. Overexpression or conditional activation of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94936eec5d1d058e2015742000154dff
https://dspace.library.uu.nl/handle/1874/7944
https://dspace.library.uu.nl/handle/1874/7944
Publikováno v:
Journal of anatomy.
Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kin
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
Publikováno v:
Nature, 404(6779), 782. Nature publishing group
The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a Forkhead factor that regulates longevity in Caenorhabditis elegans1, 2, 3. Here we show that overexpression of these Forkhead transcription factors causes growth su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb712d0affd5a053ef132a4f7210a9e
https://dspace.library.uu.nl/handle/1874/7911
https://dspace.library.uu.nl/handle/1874/7911
Autor:
John R. Yates, Don W. Cleveland, René H. Medema, Nannette Jelluma, Arjan B. Brenkman, Ian McLeod, Geert J. P. L. Kops
Publikováno v:
PloS one, vol 3, iss 6
PLoS ONE
PLoS ONE, Vol 3, Iss 6, p e2415 (2008)
PLoS ONE
PLoS ONE, Vol 3, Iss 6, p e2415 (2008)
Author(s): Jelluma, Nannette; Brenkman, Arjan B; McLeod, Ian; Yates, John R; Cleveland, Don W; Medema, Rene H; Kops, Geert JPL | Abstract: BackgroundChromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occas
Autor:
Geert J. P. L. Kops
Publikováno v:
Frontiers in Bioscience. :3606
The two daughter cells that result from each and every cell division receive an identical set of chromosomes. This is accomplished by pulling each copy of a pair of duplicated sister chromatids to opposite poles during mitosis. Inaccuracies in this p
Autor:
José María Carazo, Judith Klumperman, Carlos Sacristan, Misbha Ud Din Ahmad, Roberto Melero, Eelco C. Tromer, Job Fermie, Geert J. P. L. Kops, Anastassis Perrakis, Andrea Musacchio, Vincent Groenewold, Alexander Fish, Jenny Keller
Publikováno v:
Nature cell biology
Nature Cell Biology
Nature Cell Biology, 20(7), 800. Nature Publishing Group
Nature Cell Biology, 20(7), 800-810. Nature Publishing Group
Nature Cell Biology
Nature Cell Biology, 20(7), 800. Nature Publishing Group
Nature Cell Biology, 20(7), 800-810. Nature Publishing Group
Faithful chromosome segregation depends on the ability of sister kinetochores to attach to spindle microtubules. An outer layer of the kinetochore known as the fibrous corona transiently expands in early mitosis and disassembles upon microtubule capt
Publikováno v:
Hormones & Cancer
One of the most common hallmarks of cancer cells is aneuploidy or an abnormal number of chromosomes. This abnormal chromosome content is a consequence of chromosome missegregation during mitosis, a defect that is seen more frequently in tumor cell di
Publikováno v:
Chromosoma
Fidelity of chromosome segregation is monitored by the spindle assembly checkpoint (SAC). Key components of the SAC include MAD1, MAD2, BUB1, BUB3, BUBR1, and MPS1. These proteins accumulate on kinetochores in early prometaphase but are displaced whe
Autor:
Geert J. P. L. Kops
Publikováno v:
Current Biology
Summary Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1]. In response to unattached kinetochores, the mito
Autor:
Katharina Overlack, Ivana Primorac, Mathijs Vleugel, Veronica Krenn, Stefano Maffini, Ingrid Hoffmann, Geert J P L Kops, Andrea Musacchio
Publikováno v:
eLife, Vol 4 (2015)
The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene. Subsequent sub-functionalization established subordinati
Externí odkaz:
https://doaj.org/article/d58b367dc64a442eaf360a3ccefc8014