Zobrazeno 31 - 40
of 333
pro vyhledávání: '"Friedrich Koch-Nolte"'
Autor:
Björn Rissiek, Joschi Stabernack, Maike Cordes, Yinghui Duan, Sarah Behr, Stephan Menzel, Tim Magnus, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2020)
ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD+) triggers cell death. Since NAD+ is released as a danger signal du
Externí odkaz:
https://doaj.org/article/b828aac893134cff8c5a9f21ed17b0f1
Autor:
Philine Bergmann, Elvira Garcia de Paco, Björn Rissiek, Stephan Menzel, Gudrun Dubberke, Jennifer Hua, François Rassendren, Lauriane Ulmann, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The P2X4 channel is involved in different physiological and pathological conditions and functions in the nervous system. Despite the existence of several mouse models for which the expression of the gene was manipulated, there is still little informa
Externí odkaz:
https://doaj.org/article/9af518ef8fb64e41afbbf6c4f47525f5
Autor:
Sonia García-Rodríguez, Antonio Rosal-Vela, Davide Botta, Luz M. Cumba Garcia, Esther Zumaquero, Verónica Prados-Maniviesa, Daniela Cerezo-Wallis, Nicola Lo Buono, José-Ángel Robles-Guirado, Salvador Guerrero, Elena González-Paredes, Eduardo Andrés-León, Ángel Corbí, Matthias Mack, Friedrich Koch-Nolte, Ramón Merino, Mercedes Zubiaur, Frances E. Lund, Jaime Sancho
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
Abstract In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38 −/−) but not ART2-deficient (Art2 −/−) mice developed less severe lupus compared to wild type (WT) mice, and their prot
Externí odkaz:
https://doaj.org/article/8fe211be315c44d088247d42cd122a41
Autor:
Franziska Brauneck, Elisa Seubert, Jasmin Wellbrock, Julian Schulze zur Wiesch, Yinghui Duan, Tim Magnus, Carsten Bokemeyer, Friedrich Koch-Nolte, Stephan Menzel, Walter Fiedler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12919 (2021)
This study aimed to characterize different natural killer (NK) cell phenotypes on bone marrow and peripheral blood cells from acute myeloid leukemia (AML) patients and healthy donors (HDs). Our data show that CD56dimCD16− and CD56brightCD16− NK c
Externí odkaz:
https://doaj.org/article/622102f84222419e89204b0408b4c464
Autor:
Björn Rissiek, Stephan Menzel, Mario Leutert, Maike Cordes, Sarah Behr, Larissa Jank, Peter Ludewig, Mathias Gelderblom, Anne Rissiek, Sahil Adriouch, Friedrich Haag, Michael O. Hottiger, Friedrich Koch-Nolte, Tim Magnus
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Mammalian ecto-ADP-ribosyltransferases (ecto-ARTs or also ARTCs) catalyze the ADP-ribosylation of cell surface proteins using extracellular nicotinamide adenine dinucleotide (NAD+) as substrate. By this post-translational protein modificatio
Externí odkaz:
https://doaj.org/article/b1ae8aec05a84e56935b6f2b9f614cd9
Autor:
Kathrin Koch, Sarah Kalusche, Jonathan L. Torres, Robyn L. Stanfield, Welbeck Danquah, Kamal Khazanehdari, Hagen von Briesen, Eric R. Geertsma, Ian A. Wilson, Ulrich Wernery, Friedrich Koch-Nolte, Andrew B. Ward, Ursula Dietrich
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Broadly neutralizing antibodies (bnAbs) against HIV-1 protect from infection and reduce viral load upon therapeutic applications. However no vaccine was able so far to induce bnAbs demanding their expensive biotechnological production. For c
Externí odkaz:
https://doaj.org/article/065cbec988884c7d94a11dd65043ca0e
Autor:
Kerstin Schütze, Katharina Petry, Julia Hambach, Niklas Schuster, William Fumey, Levin Schriewer, Jana Röckendorf, Stephan Menzel, Birte Albrecht, Friedrich Haag, Catelijne Stortelers, Peter Bannas, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in came
Externí odkaz:
https://doaj.org/article/73386a564c9a465d8f987c717ce73431
Autor:
Peter Bannas, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The NAD+-metabolizing ectoenzyme CD38 is an established therapeutic target in multiple myeloma. The CD38-specific monoclonal antibodies daratumumab and isatuximab show promising results in the clinic. Nanobodies correspond to the single variable doma
Externí odkaz:
https://doaj.org/article/bfa4a4bc005b47d186f087abf78a1538
Autor:
Natalie Baum, Ralf Fliegert, Andreas Bauche, Julia Hambach, Stephan Menzel, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Publikováno v:
Cancers, Vol 13, Iss 1, p 76 (2020)
The nucleotides ATP and NAD+ are released from stressed cells as endogenous danger signals. Ecto-enzymes in the tumor microenvironment hydrolyze these inflammatory nucleotides to immunosuppressive adenosine, thereby, hampering anti-tumor immune respo
Externí odkaz:
https://doaj.org/article/1b926f34243d43058f87f16abfae501b
Autor:
Julia Hambach, Kristoffer Riecken, Sophia Cichutek, Kerstin Schütze, Birte Albrecht, Katharina Petry, Jana Larissa Röckendorf, Natalie Baum, Nicolaus Kröger, Timon Hansen, Gunter Schuch, Friedrich Haag, Gerhard Adam, Boris Fehse, Peter Bannas, Friedrich Koch-Nolte
Publikováno v:
Cells, Vol 9, Iss 2, p 321 (2020)
The NAD-hydrolyzing ecto-enzyme CD38 is overexpressed by multiple myeloma and other hematological malignancies. We recently generated CD38-specific nanobodies, single immunoglobulin variable domains derived from heavy-chain antibodies naturally occur
Externí odkaz:
https://doaj.org/article/45aa97fe88f54d0990491ef3c162f04d