Zobrazeno 1 - 10
of 37
pro vyhledávání: '"François Van Laethem"'
Autor:
François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is ref
Externí odkaz:
https://doaj.org/article/76e87e0eec1242be99fc58fb598e83f1
Autor:
François Van Laethem, Lucie Donaty, Emmanuelle Tchernonog, Vanessa Lacheretz-Szablewski, Jennifer Russello, Delphine Buthiau, Marion Almeras, Jérôme Moreaux, Caroline Bret
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16136 (2022)
Leukocyte-associated immunoglobulin (Ig)-like receptor 1 (LAIR1, CD305) belongs to the family of immune-inhibitory receptors and is widely expressed on hematopoietic mature cells, particularly on immune cells. Four different types of ligands of LAIR1
Externí odkaz:
https://doaj.org/article/fff58d80e4e04b919117eb56911f5008
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
Sylvain Lamure, François Van Laethem, Delphine De Verbizier, Claire Lozano, Eve Gehlkopf, Jean-Jacques Tudesq, Chris Serrand, Mehdi Benzaoui, Tarik Kanouni, Adeline Quintard, John De Vos, Emmanuelle Tchernonog, Laura Platon, Xavier Ayrignac, Patrice Ceballos, Anne Sirvent, Mickael François, Hanane Guedon, Philippe Quittet, Cedric Mongellaz, Aurélie Conte, Charles Herbaux, Caroline Bret, Naomi Taylor, Valérie Dardalhon, Guillaume Cartron
Publikováno v:
Cancers, Vol 13, Iss 17, p 4279 (2021)
CD19-directed CAR T-cells have been remarkably successful in treating patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (t-FL). In this cohort study, we treated 60 patients with axicabta
Externí odkaz:
https://doaj.org/article/18d259bf18bf49c0b5ca539933d6cc69
Autor:
Anne Sirvent, Claire Lozano, Cédric Mongellaz, Guillaume Cartron, Hanane Guedon, François Van Laethem, Adeline Quintard, Mehdi Benzaoui, John De Vos, Aurélie Conte, Laura Platon, Jean-Jacques Tudesq, Delphine De Verbizier, Tarik Kanouni, Xavier Ayrignac, Patrice Ceballos, Chris Serrand, Mickael François, Emmanuelle Tchernonog, Eve Gehlkopf, Naomi Taylor, Valerie Dardalhon, Sylvain Lamure, Caroline Bret, Charles Herbaux, Philippe Quittet
Publikováno v:
Cancers, Vol 13, Iss 4279, p 4279 (2021)
Cancers
Cancers, MDPI, 2021, 13 (17), pp.4279. ⟨10.3390/cancers13174279⟩
Volume 13
Issue 17
Cancers
Cancers, MDPI, 2021, 13 (17), pp.4279. ⟨10.3390/cancers13174279⟩
Volume 13
Issue 17
CD19-directed CAR T-cells have been remarkably successful in treating patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and transformed follicular lymphoma (t-FL). In this cohort study, we treated 60 patients with axicabta
Autor:
Terry I. Guinter, Mirelle Rojano, Britta Engelhardt, Ingrid Saba, James Chih-Hsin Yang, Abhisek Bhattacharya, Jinghua Lu, Ken-ichi Hanada, Amala Alag, Alfred Singer, François Van Laethem, Peter D. Sun, Jennifer M. Ashe, Xuguang Tai
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Autor:
Abhisek Bhattacharya, Alfred Singer, Jinghua Lu, Ingrid Saba, Jonathan Chu, Peter D. Sun, François Van Laethem, Anastasia N. Tikhonova
Publikováno v:
J Immunol
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide–MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficient mice,
Autor:
Steven Le Gouill, Emmanuel Bachy, Roberta Di Blasi, Elodie Gat, François Van Laethem, Loic Ysebaert, Remy Dulery, Florence Broussais, Mikael Roussel, Caroline Bret, Guillaume Cartron, Rene-Olivier Casasnovas, Charles Herbaux, Arnaud Campidelli, Julien Guy, Roch Houot, David Beauvais, Franck Morschhauser, Krimo Bouabdallah, Alexis Cuffel, Sophie Caillat-Zucman, Thomas Gastinne
Publikováno v:
Blood. 138:743-743
Introduction The French health agency granted access to KTE-X19 in its early access program (French ATUs) for patients with relapsed or refractory (R/R) mantle-cell lymphoma (MCL) who failed after at least one line of chemoimmunotherapy and Bruton's
Autor:
Tomer Arnon, Marco Craveiro, Nicholas C. Love, Sergei Radaev, Nan-ping Weng, Abhisek Bhattacharya, Xiaoping Sun, Jonathan Chu, Jinghua Lu, Nir Friedman, Ingrid Saba, Eric Shifrut, Anastasia N. Tikhonova, Alfred Singer, Annette Ko, Peter D. Sun, François Van Laethem
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection repertoire is not known. Here we perform comparative repertoire s