Zobrazeno 11 - 20
of 37
pro vyhledávání: '"François Van Laethem"'
Autor:
Yan Xing, Shigeo Murata, Keiji Tanaka, Haruhiko Suzuki, Stephen C. Jameson, Alfred Singer, Yousuke Takahama, François Van Laethem, Kazuyuki Akane, Kensuke Takada
Publikováno v:
Nature Immunology. 16:1069-1076
In the thymus, low-affinity T cell antigen receptor (TCR) engagement facilitates positive selection of a useful T cell repertoire. Here we report that TCR responsiveness of mature CD8(+) T cells is fine tuned by their affinity for positively selectin
Autor:
Nir Friedman, Tomer Arnon, Alfred Singer, Irun R. Cohen, François Van Laethem, Peter D. Sun, Asaf Madi, Erez Greenstein, Irena Zaretsky, Shlomit Reich-Zeliger, Jinghua Lu, Eric Shifrut, Asaf Poran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2def802ae258300256d12a94f887d82a
https://doi.org/10.7554/elife.22057.030
https://doi.org/10.7554/elife.22057.030
Autor:
Peter D. Sun, Jinghua Lu, Irena Zaretsky, Irun R. Cohen, Alfred Singer, Erez Greenstein, François Van Laethem, Asaf Madi, Nir Friedman, Eric Shifrut, Asaf Poran, Shlomit Reich-Zeliger, Tomer Arnon
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between species has not been characterized. Using n
Autor:
Alfred Singer, Terry I. Guinter, Motoko Y. Kimura, Lionel Feigenbaum, Anthony J. Adams, Anastasia N. Tikhonova, François Van Laethem, Xuguang Tai, Susan O. Sharrow, Cecile Le Saout, Leonid A. Pobezinsky, Günter Bernhardt
Publikováno v:
Cell. 154:1326-1341
Summary Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not understood, the thymus selects only αβTCR that are restricted by major histocompatibi
Autor:
Susan O. Sharrow, Larry Granger, Tullia Lindsten, Craig B. Thompson, François Van Laethem, Xuguang Tai, Terry I. Guinter, Anthony J. Adams, Lionel Feigenbaum, Alfred Singer, Leonid A. Pobezinsky, Michael J. Kruhlak
Publikováno v:
Blood. 119:5155-5163
CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tcon
Autor:
Anastasia N. Tikhonova, Terry I. Guinter, François Van Laethem, Susanna Jeurling, Jinghua Lu, Günter Bernhardt, Changwan Hong, Peter D. Sun, James Chih-Hsin Yang, Ken-ichi Hanada, Leonid A. Pobezinsky, Jung-Hyun Park, Alfred Singer
Publikováno v:
Immunity. 36:79-91
Summary Major histocompatibility complex (MHC) restriction is the cardinal feature of T cell antigen recognition and is thought to be intrinsic to αβ T cell receptor (TCR) structure because of germline-encoded residues that impose MHC specificity.
Autor:
Tom M. McCaughtry, Alex Grinberg, Amala Alag, Alfred Singer, Lie Wang, Jung-Hyun Park, Rémy Bosselut, Motoko Y. Kimura, Xuguang Tai, François Van Laethem, Stanley Adoro, Batu Erman, Paul E. Love, Masato Kubo
Publikováno v:
The EMBO Journal. 31:366-377
Immature thymocytes are bipotential cells that are signalled during positive selection to become either helper- or cytotoxic-lineage T cells. By tracking expression of lineage determining transcription factors during positive selection, we now report
Publikováno v:
Proceedings of the National Academy of Sciences. 104:13756-13761
CTLA-4-deficient mice develop a lethal autoimmune lymphoproliferative disorder that is strictly dependent onin vivoCD28 costimulation. Nevertheless, it is not known whether there is a specific site on the CD28 molecule that is required for induction
Autor:
Michael J. Kruhlak, Oscar Fernandez-Capetillo, R. Daniel Camerini-Otero, Hua-Tang Chen, Yongping Yang, Bernardo Reina San Martin, Michel C. Nussenzweig, Lionel Feigenbaum, Simone Difilippantonio, Arkady Celeste, Galina V. Petukhova, André Nussenzweig, François Van Laethem, Shyam K. Sharan, Katia Manova, Michael Eckhaus
Publikováno v:
Nature Cell Biology. 7:675-685
Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (A
Autor:
Miho Shinzawa, Alfred Singer, Susanna Jeurling, François Van Laethem, Gil Katz, Leonid A. Pobezinsky
T cell receptor (TCR)–mediated inhibition of interleukin-7 (IL-7) signaling is important for lineage fate determination in the thymus and for T cell survival in the periphery because uninterrupted IL-7 signaling results in T cell death. The initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04b14f42a06b3d9e5be33e473869668
https://europepmc.org/articles/PMC6679598/
https://europepmc.org/articles/PMC6679598/