Zobrazeno 41 - 50
of 117
pro vyhledávání: '"Fernando Souza-Fonseca-Guimaraes"'
Publikováno v:
Seminars in Hematology. 57:194-200
Natural killer (NK) cells are an important component of the innate immune system, particularly for metastasis immunosurveillance. They can rapidly recognize and kill transformed cells without the requirement of specific neo-antigen recognition. Their
Autor:
Fernando Souza-Fonseca-Guimaraes, Gustavo R. Rossi, Laura F. Dagley, Momeneh Foroutan, Timothy R. McCulloch, Jumana Yousef, Hae-Young Park, Jennifer H. Gunter, Paul A. Beavis, Cheng-Yu Lin, Soroor Hediyeh-Zadeh, Tania Camilleri, Melissa J. Davis, Nicholas D. Huntington
Publikováno v:
Cancer immunology research. 10(9)
Antibodies targeting “immune checkpoints” have revolutionized cancer therapy by reactivating tumor-resident cytotoxic lymphocytes, primarily CD8+ T cells. Interest in targeting analogous pathways in other cytotoxic lymphocytes is growing. Natural
Autor:
Nicholas D. Huntington, Jai Rautela, Lynn M. Corcoran, Rebecca B. Delconte, Andrew I. Webb, Joanna R Groom, Ngaire Elwood, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Tobias Kratina, Fernando Souza-Fonseca-Guimaraes, Laura F. Dagley
Publikováno v:
Molecular Immunology. 115:56-63
NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually expresses high levels of the Inhibitor of DNA-binding 2 (Id2) protein and loss of Id2 is incongruous with their survival due to
Autor:
Timothy J. Wells, Timothy McCulloch, Gustavo Rodrigues Rossi, Fernando Souza-Fonseca-Guimaraes
Immunotherapy has revolutionized cancer therapy by reactivating tumor-resident cytotoxic lymphocytes. More recently, immunotherapy has emerged to restore immunity against infectious agents, including bacterial infections. Immunotherapy primarily targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6073a572c94e619cfe79cbe0d7d9d37
https://doi.org/10.1101/2021.11.29.470332
https://doi.org/10.1101/2021.11.29.470332
Autor:
Timothy J. Wells, Ya Wang, Jon Iredell, Amy Phu, Sally Teoh, Win Sen Kuan, Yanshan Zhu, Melissa J. Davis, Timothy McCulloch, Majid Ebrahimi Warkiani, Tiana M Pelaia, Yao Xia, Chin Wee Tan, Timothy Kwan, Lucia de Noronha, Velma Herwanto, Reza Alizadeh-Navaei, Amir Shamshirian, Carmen Lúcia Kuniyoshi Rebelatto, John F. Fraser, Tracy Chew, Reza Valadan, Liliana Lamperti, Kenneth J. O'Byrne, Marek Nalos, Gabrielle T. Belz, Yvette Jee, Quan Nguyen, Keng Yih Chew, Maryam Shojaei, Anthony S. McLean, Benjamin Tang, Alexandra Cristina Senegaglia, Carlos Salomon Gallo, Laura F. Grice, Ben Knippenberg, Arutha Kulasinghe, Kirsty R. Short, Felipe Zuñiga, Omolbanin Amjadi, Sepideh Motamen, Estefania Nova-Lamperti, Rajan Gogna, Anna Flavia Ribeiro dos Santos, Minh Tran, Karan Kim, Fernando Souza-Fonseca-Guimaraes, James Monkman, Gustavo Rodrigues Rossi, Gonzalo Labarca, Esha Madan, Claudio Luciano Franck
BackgroundRobust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43dd230438b36df1bcefeac6c9ac27b
https://doi.org/10.1101/2021.10.29.21265555
https://doi.org/10.1101/2021.10.29.21265555
Autor:
Phillip K. Darcy, Angela Pizzolla, Rosemary Millen, Jessica Michie, James McCluskey, Timothy McCulloch, Junyun Lai, Jeffrey Y. W. Mak, Jack D Chan, Jasmine Li, Jane Oliaro, Amanda X. Y. Chen, Emma V. Petley, Paul A. Beavis, Imran G House, Kevin Sek, Hui-Fern Koay, Simon P. Keam, Robert G. Ramsay, Nicholas D. Huntington, Paul J Neeson, Dale I. Godfrey, Lauren Giuffrida, Melissa A. Henderson, Fernando Souza-Fonseca-Guimaraes, Amanda J Oliver, Andrew J. Freeman, Conor J. Kearney, Kirsten L. Todd, Magnus Zethoven, David P. Fairlie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice. An
Autor:
Ariel Munitz, Kylie Luong, Andrew N. J. McKenzie, Jaring Schreuder, Wei Shi, Minyu Wang, Sharon Grisaru-Tal, Melissa J. Davis, Paul S. Foster, Joseph A. Trapani, Bogoljub Ciric, Sean Macdonald, Kevin Y. T. Thia, Soroor Hediyeh-Zadeh, Cynthia Louis, Ian P. Wicks, Stephen L. Nutt, Qiutong Huang, Jonathan Cebon, Shengbo Zhang, Daniel H.D. Gray, Paul J Neeson, Andreas Behren, Philip M. Hansbro, Cyril Seillet, Michael Chopin, Nicolas Jacquelot, Viktor Umansky, Angela Pizzolla, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Mary J Camilleri, Tristan Molden-Hauer, Yang Liao, Eric Vivier, Carolyn A. de Graaf, Gabrielle T. Belz
Publikováno v:
Nature Immunology
Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩
Nature immunology
Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩
Nature immunology
International audience; Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58b04f1a688fd896b85f7433ff098a9
https://hdl.handle.net/10453/155659
https://hdl.handle.net/10453/155659
Autor:
Andreas Behren, Fernando Souza-Fonseca-Guimaraes, Nicholas D. Huntington, Melissa J. Davis, Joseph Cursons, Soroor Hediyeh-Zadeh, Momeneh Foroutan, Ashley R. Anderson, Frédéric Hollande
Publikováno v:
Cancer Immunology Research. 7:1162-1174
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other innate immune components could be exploitable for cancer treatment, which drives the need for tools and m
Publikováno v:
Trends in Immunology. 40:142-158
Immune ‘checkpoint’ inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory pathways in tumor-infiltrating CD8+ T cells and recent studies have show
Publikováno v:
The Journal of Immunology. 208:164.01-164.01
Immune “checkpoint” inhibitor antibodies have revolutionized cancer therapy and function by reactivating tumor-resident cytotoxic lymphocytes, primarily CD8 T cells. Recent studies have also shown similar programs in other effector lymphocyte pop