Zobrazeno 21 - 30
of 66
pro vyhledávání: '"Ernest S. Smith"'
Autor:
Michael C. Lowe, Clint T. Allen, Nabil F. Saba, Christina Wu, Ernest S. Smith, Conor E. Steuer, John E. Leonard, Paul E. Clavijo, Gregory B. Lesinski, Desa Rae Pastore, Brian Olson, Elizabeth E. Evans, Crystal Mallow, Ragini R. Kudchadkar, Terrence L. Fisher, Maurice Zauderer
Publikováno v:
Clinical Cancer Research. 26:A15-A15
Recruitment of immunosuppressive myeloid cells into the tumor microenvironment (TME) is a critical limitation to the efficacy of immune checkpoint inhibitors (ICIs) in patients with head and neck squamous cell carcinoma (HNSCC). In preclinical models
Autor:
Desa Rae Pastore, Kevin M. Chin, Nashat Y. Gabrail, JT Beck, Aaron S. Mansfield, Andreas Schröder, Alexander I. Spira, Yanyan Lou, Michael Shafique, Crystal Mallow, Megan Ann Baumgart, Terrence L. Fisher, Ernest S. Smith, Rachel E. Sanborn, Nagashree Seetharamu, Maurice Zauderer, Elizabeth E. Evans, Ramaswamy Govindan, John E. Leonard, Jonathan W. Goldman
Publikováno v:
Journal of Clinical Oncology. 38:3011-3011
3011 Background: Antibody blockade of semaphorin 4D (SEMA4D, CD100) promotes tumoral dendritic cell and CD8+ T cell infiltration and reduces function and recruitment of immunosuppressive myeloid cells. Importantly, these mechanisms to overcome immune
Autor:
Gregory B. Lesinski, Mihir R. Patel, Brian Olson, Crystal Mallow, Michael C. Lowe, Ragini R. Kudchadkar, Conor E. Steuer, Elizabeth E. Evans, John E. Leonard, Terrence L. Fisher, Christina Wu, Maurice Zauderer, Desa Rae Pastore, Nabil F. Saba, Ernest S. Smith
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 106:1175
Autor:
Andreas Schröder, Ramaswamy Govindan, Elizabeth E. Evans, Jonathan W. Goldman, John E. Leonard, Nagashree Seetharamu, Kevin M. Chin, Megan Ann Baumgart, Desa Rae Pastore, Yan Yan Lou, Rachel E. Sanborn, Aaron S. Mansfield, Nashat Y. Gabrail, Terrence L. Fisher, J. Thaddeus Beck, Ernest S. Smith, Maurice Zauderer, Alexander I. Spira, Crystal Mallow, Michael Shafique
Publikováno v:
Journal of Clinical Oncology. 38:75-75
75 Background: Despite progress of immune checkpoint therapies, many cases of non-small cell lung cancer (NSCLC) are refractory or acquire resistance to current therapies. Antibody blockade of semaphorin 4D (SEMA4D, CD100) can overcome resistance mec
Autor:
Andrew Feigin, Crystal Mallow, Leslie Balch, John E. Leonard, Ernest S. Smith, Alisha M. Reader, Maurice Zauderer, Alan Howell, Terrence L. Fisher, Elizabeth E. Evans
Publikováno v:
Alzheimer's & Dementia. 15:P926-P927
Autor:
Boguslaw Felczak, Sabine Waltl, George Hall, Erika B. Villanueva, Yuanyun Xie, Michael R. Hayden, Weining Zhang, Ernest S. Smith, Amber L. Southwell, Maurice Zauderer, Vlad Kovalik, Laurie A. Winter, Alan S. Jonason, Sonia Franciosi, William J. Bowers, Mahmoud A. Pouladi, Janaki Veeraraghavan
Publikováno v:
Neurobiology of Disease, Vol 76, Iss, Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Autor:
Thaddeus Beck, Ernest S. Smith, Elizabeth E. Evans, Terrence L. Fisher, John E. Leonard, Jonathan W. Goldman, Crystal Mallow, Desa Rae Pastore, Rachel E. Sanborn, Megan Ann Baumgart, Michael Shafique, Kevin M. Chin, Maurice Zauderer, Andreas Schroeder
Publikováno v:
Cancer Research. 79:CT086-CT086
Background: Blockade of the PD/PD-L1 pathway is an effective immunotherapy for NSCLC, however rational combination therapies are needed to overcome resistance mechanisms. VX15/2503 (pepinemab) is an IgG4 humanized monoclonal antibody targeting semaph
Autor:
Brian Olson, Michael C. Lowe, Maurice Zauderer, Desa Rae Pastore, Crystal Mallow, Conor E. Steuer, John E. Leonard, Ernest S. Smith, Elizabeth E. Evans, Gregory B. Lesinski, Nabil F. Saba, Christina Wu, Ragini R. Kudchadkar, Terrence L. Fisher
Publikováno v:
Cancer Research. 79:CT016-CT016
Interrogation of the tumor microenvironment (TME) is crucial to provide insight into biological activity, resistance mechanisms and implementation of rational combination immunotherapies. Semaphorin 4D (SEMA4D, CD100) has broad immunomodulatory effec
Autor:
Conor E. Steuer, Elizabeth E. Evans, Gregory B. Lesinski, Antoni Ribas, Maria Scrivens, Emily Greengard, Alan Howell, Brian Olson, Paul E. Clavijo, Ernest S. Smith, Siwen Hu-Lieskovan, Terrence L. Fisher, Clint T. Allen, Leslie Balch, Sebold Torno, Christina Wu, Christine Reilly, Maurice Zauderer, Nabil F. Saba, Crystal Mallow, Desa Rae Pastore, John E. Leonard, Holm Bussler
Publikováno v:
Cancer Research. 79:1545-1545
Anti-semaphorin 4D (SEMA4D, CD100) blocking antibody promotes immune infiltration, reduces immunosuppressive myeloid cells, and enhances T cell activity and tumor growth inhibition in combination with various immunotherapies in preclinical animal mod
Autor:
Alan Howell, Emily Greengard, Holm Bussler, Paul E. Clavijo, Gregory Lesiniski, Terrence L. Fisher, Crystal Mallow, Christina Wu, Christine Reilly, Siwen Hu-Lieskovan, Ernest S. Smith, Antoni Ribas, Maurice Zauderer, Clint T. Allen, Leslie Balch, Maria Scrivens, Elizabeth E. Evans, John E. Leonard, Sebold Torno
Publikováno v:
Cancer Immunology Research. 7:PR10-PR10
Purpose: Tumor growth inhibition by anti-semaphorin 4D (SEMA4D, CD100) blocking antibody is enhanced when combined with various immunotherapies in preclinical animal models. Immune checkpoint combinations with pepinemab (VX15/2503), a humanized anti-