Zobrazeno 41 - 50
of 237
pro vyhledávání: '"Eric L. Nuermberger"'
Publikováno v:
Antimicrob Agents Chemother
The novel regimen of bedaquiline, pretomanid, and linezolid (BPaL) is highly effective against drug-resistant tuberculosis, but linezolid toxicities are frequent. We hypothesized that, for a similar total weekly cumulative dose, thrice-weekly adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54d7dd726cba87b214cb7d32194e8a7
https://europepmc.org/articles/PMC7508620/
https://europepmc.org/articles/PMC7508620/
Autor:
Thomas R. Ioerger, Jin Lee, Keshav Shah, Jean Philippe Lanoix, Dalin Rifat, Ghader Bashiri, Eric L. Nuermberger, James C. Sacchettini, Si-Yang Li
Publikováno v:
Antimicrob Agents Chemother
The nitroimidazole pro-drugs delamanid and pretomanid comprise one of only two new antimicrobial classes approved to treat tuberculosis (TB) in 50 years. Prior in vitro studies suggest a relatively low barrier to nitroimidazole resistance in Mycobact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a820ae68d98fdaf0b069e62cf70104a
https://doi.org/10.1101/2020.09.10.292508
https://doi.org/10.1101/2020.09.10.292508
Autor:
Qianwen Wang, Véronique Dartois, Rada M. Savic, Natasha Strydom, Eric L. Nuermberger, Jacqueline P Ernest, Nan Zhang
Publikováno v:
Annu Rev Pharmacol Toxicol
Annual review of pharmacology and toxicology, vol 61, iss 1
Annual review of pharmacology and toxicology, vol 61, iss 1
Tuberculosis (TB) kills more people than any other infectious disease. Challenges for developing better treatments include the complex pathology due to within-host immune dynamics, interpatient variability in disease severity and drug pharmacokinetic
The novel regimen of bedaquiline, pretomanid, and linezolid (BPaL) is highly effective against drug resistant tuberculosis, but linezolid toxicities are frequent. We hypothesized that, for a similar total weekly cumulative dose, thrice-weekly adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3444cd6969c5c52dde48ca2403fec13c
https://doi.org/10.1101/2020.06.10.145334
https://doi.org/10.1101/2020.06.10.145334
Autor:
Deepak V. Almeida, Jeongjun Kim, Sandeep Tyagi, Eric L. Nuermberger, Paul J. Converse, Till F. Omansen, Rokeya Tasneen
Publikováno v:
Antimicrobial Agents and Chemotherapy, 64(6):e00259-20. AMER SOC MICROBIOLOGY
Antimicrob Agents Chemother
Antimicrob Agents Chemother
Telacebec (Q203) is a new antitubercular drug with extremely potent activity against Mycobacterium ulcerans. Here, we explored the treatment-shortening potential of Q203 alone or in combination with rifampin (RIF) in a mouse footpad infection model.
Publikováno v:
C106. BASIC AND TRANSLATIONAL DISCOVERIES IN TB AND MYCOBACTERIAL DISEASES.
Autor:
Eric L. Nuermberger, Xiaoyi Wang, Lianmeng Shi, Jingtao Dai, Hongying Zheng, Xiuzhen Ma, Huanying Bai, Ma Zhuo, Xiaoli Ma, Aiqi Xi, Jian Xu, Yuehe Ding
Publikováno v:
Journal of Medical Virology
Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f930189599655bfa9f71a49866f23b35
Autor:
Kelly E, Dooley, Sachiko, Miyahara, Florian, von Groote-Bidlingmaier, Xin, Sun, Richard, Hafner, Susan L, Rosenkranz, Elisa H, Ignatius, Eric L, Nuermberger, Laura, Moran, Kathleen, Donahue, Susan, Swindells, Naadira, Vanker, Andreas H, Diacon
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Autor:
Eric L. Nuermberger, Heena Soni, Natasha Strydom, Nan Zhang, Rokeya Tasneen, Rada M. Savic, Sandeep Tyagi
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial agents and chemotherapy, vol 64, iss 3
Antimicrobial agents and chemotherapy, vol 64, iss 3
Tuberculosis (TB) drug, regimen, and vaccine development rely heavily on preclinical animal experiments, and quantification of bacterial and immune response dynamics is essential for understanding drug and vaccine efficacy. A mechanism-based model wa
Autor:
Xingshan Cai, Yuanyuan Cao, Yaoju Tan, Peipei Zhou, Shuai Wang, H.M. Adnan Hameed, Sheng Zeng, Yang Liu, Tianyu Zhang, Jianxiong Liu, Xiaoyun Lu, Guoliang Zhang, Eric L. Nuermberger, Huancai Yin, Mahmudul Islam, Julius Mugweru
Publikováno v:
Antimicrob Agents Chemother
Mycobacterium abscessus is intrinsically resistant to most antimicrobial agents. The emerging infections caused by M. abscessus and the lack of effective treatment call for rapid attention. Here, we intended to construct a selectable marker-free auto