Zobrazeno 31 - 40
of 55
pro vyhledávání: '"Emma S. Jones"'
Publikováno v:
Journal of Molecular and Cellular Cardiology. 37:1023-1030
Ang II acting at AT(1)Rs has well documented effects on cardiovascular structure such as the promotion of cardiovascular hypertrophy and fibrosis, effects which are believed to be opposed by AT(2)R stimulation. AT(1) and AT(2)R expression are up regu
Publikováno v:
British Journal of Pharmacology. 140:809-824
It is widely accepted that the angiotensin II type 1 receptor (AT1R) accounts for the majority of cardiovascular effects evoked by angiotensin II (Ang II), such as contraction/pressor activity and growth-promoting effects leading to cardiac and vascu
Publikováno v:
Journal of Hypertension. 34:e290
Autor:
Ross A. D. Bathgate, Tim D. Hewitson, Mohsin Sarwar, Robert E Widdop, Martina Kocan, Bryna Sm Chow, Emma S Jones, Roger J. Summers, Belinda Wigg, Sanja Bosnyak, Chrishan S. Samuel
Publikováno v:
Kidney international
Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic therapy; however, its mechanism of action is poorly understood. Recent studies have shown t
Autor:
Sonja Tesanovic, Kljajic, Robert E, Widdop, Antony, Vinh, Iresha, Welungoda, Sanja, Bosnyak, Emma S, Jones, Tracey A, Gaspari
Publikováno v:
International journal of cardiology. 169(4)
The angiotensin II type 2 receptor (AT₂R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis. Thus this study aimed to determine the effect
Autor:
Samy Sakkal, Sharon D. Ricardo, Antony Vinh, Robert E Widdop, Elizabeth Guida, Christopher G. Sobey, Christopher T. Chan, Jeffrey P Moore, Klaudia Budzyn, Henry Diep, Emma S Jones, Grant R Drummond, James A. Armitage
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 60(5)
Infiltration of macrophages into the artery wall plays detrimental roles during hypertension by promoting vascular inflammation and endothelial dysfunction, and it occurs via a chemo-attractant action of chemokines on macrophage cytokine receptors. W
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 60(1)
See related article, pp 137–144 In recent years there has been a revolution in our knowledge of the renin-angiotensin (Ang) system (RAS), with the identification of novel functions for biologically active Ang peptides and receptors and the discover
Publikováno v:
International Journal of Hypertension, Vol 2012 (2012)
International Journal of Hypertension
International Journal of Hypertension
Angiotensin (1-7) (Ang (1-7)) causes vasodilator effects in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs) via angiotensin type 2 receptors (AT2R). However, the role of vascular AT2R in aging is not known. Therefore, we examined t
Autor:
Lucinda M Hilliard, Geoffrey A. Head, Russell D. Brown, Emma S Jones, Kate M. Denton, Robert E Widdop
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 59(1)
Awareness of sex differences in the pathology of cardiovascular disease is increasing. Previously, we have shown a role for the angiotensin type 2 receptor (AT 2 R) in the sex differences in the arterial pressure response to Ang II. Tubuloglomerular
Publikováno v:
International Journal of Hypertension
Cardiac AT(2)R expression is upregulated in the normal process of aging. In this study we determined the contribution of AT(2)R to chronic antihypertensive and remodelling effects of AT(1)R blockade in aged hypertensive rats. Adult (20 weeks) and sen