Zobrazeno 71 - 80
of 164
pro vyhledávání: '"Emanuela Felley-Bosco"'
Autor:
Emanuela Felley-Bosco, Lorenza Penengo, Saskja Bühler, Egbert F. Smit, Meulen-Muileman IVd, Menezes Rd, Walter Weder, Agata Okonska, Beusechem Vv, Rao, Maxime Blijlevens, Manuel Ronner, Rolf A. Stahel
IntroductionLoss of function of BRCA1 associated protein 1 (BAP1) is observed in about 50% of malignant pleural mesothelioma (MPM) cases. The aim of this study was to investigate whether this aspect could be exploited for targeted therapy.MethodsA ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab334d7ebc143ddb6567b2bf3db5c73
The in vitro RNA-pulldown is still largely used in the first steps of protocols aimed at identifying RNA-binding proteins that recognize specific RNA structures and motifs. In this RNA-pulldown protocol, commercially synthesized RNA probes are labele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f49a627731ae130e9d5c736a49a2bc
https://doi.org/10.5167/uzh-165109
https://doi.org/10.5167/uzh-165109
Autor:
Verena Tischler, Bart Vrugt, Davide Soldini, Virginia Cecconi, Walter Weder, Paul Stolzmann, Paulino Tallón de Lara, Rolf A. Stahel, Martina Friess, Stefanie Hiltbrunner, Isabelle Opitz, Maries van den Broek, Christian Britschgi, Hideo Yagita, Alessandra Curioni-Fontecedro, Beata Bode, Emanuela Felley-Bosco
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(24)
Purpose: Combination of immune checkpoint inhibitors with chemotherapy is under investigation for cancer treatment. Experimental Design: We studied the rationale of such a combination for treating mesothelioma, a disease with limited treatment option
Autor:
Hubert Rehrauer, Emanuela Felley-Bosco
Publikováno v:
International Journal of Molecular Sciences, 19 (4)
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1163 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1163 (2018)
International Journal of Molecular Sciences
Mesothelioma is an aggressive, rapidly fatal cancer and a better understanding of its molecular heterogeneity may help with making more efficient therapeutic strategies. Non-coding RNAs represent a larger part of the transcriptome but their contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446d89fa63e1cdfde9ddd9c8aa50172a
https://hdl.handle.net/20.500.11850/261027
https://hdl.handle.net/20.500.11850/261027
Autor:
Emanuela Felley-Bosco, Walter Weder, Bart Vrugt, Peter J. Wild, Jelena Kresoja-Rakic, Rolf A. Stahel, Kathrin Oehl, Isabelle Opitz
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Frontiers in Oncology
Frontiers in Oncology
Experimental models closely representing in vivo conditions allow investigating mechanisms of resistance. Our aims were to establish a live-cell biobank of malignant pleural mesothelioma (MPM) samples, and to obtain proof of principle that primary cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaeb863a9fdd4ee2c9e11117add44969
https://doi.org/10.5167/uzh-153276
https://doi.org/10.5167/uzh-153276
Autor:
Licun Wu, László Pecze, Janine Worthmüller-Rodriguez, Beat Schwaller, Walter Blum, Emanuela Felley-Bosco, Marc de Perrot, Bart Vrugt
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal
Mesothelial cells are susceptible to asbestos fiber-induced cytotoxicity and on longer time scales to transformation; the resulting mesothelioma is a highly aggressive neoplasm that is considered as incurable at the present time Zucali et al. (Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e850a1c4ec302f314031ca5fd7ec6965
https://www.zora.uzh.ch/id/eprint/146544/
https://www.zora.uzh.ch/id/eprint/146544/
Publikováno v:
Genes, Vol 6, Iss 3, Pp 500-511 (2015)
Genes
Genes (Basel)
Genes
Genes (Basel)
Malignant pleural mesothelioma (MPM) is a cancer associated with exposure to asbestos fibers, which accumulate in the pleural space, damage tissue and stimulate regeneration. Hedgehog signaling is a pathway important during embryonic mesothelium deve
Autor:
Licun Wu, Beat Schwaller, László Pecze, Bart Vrugt, Walter Blum, Thomas Henzi, Catherine Aquino, Véronique Serre-Beinier, Hubert Rehrauer, Emanuela Felley-Bosco, Marc de Perrot
Publikováno v:
Oncogene, Vol. 37, No 20 (2018) pp. 2645-2659
Oncogene, 37
Oncogene
Oncogene, 37
Oncogene
SummaryChronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines and growth factors accumulated in the peritoneal lavage. Transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef23ba9d91c18770fb15c35747fe3d2
https://doi.org/10.1101/182980
https://doi.org/10.1101/182980
Publikováno v:
Advances in experimental medicine and biology. 1008
Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome that is emerging as a central player controlling diverse cellular mechanisms. Most of the well-studied lncRNAs so far are found to be crucial in regulating cellular p
Autor:
Rolf A. Stahel, Alessandra Curioni-Fontecedro, I. Schmitt-Opitz, Emanuela Felley-Bosco, Solange Peters, Walter Weder, Ulf Petrausch
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo, vol. 26, no. 8, pp. 1649-1660
Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo, vol. 26, no. 8, pp. 1649-1660
Malignant mesothelioma is an incurable disease associated with asbestos exposure arising in the pleural cavity and less frequently in the peritoneal cavity. Platinum-based combination chemotherapy with pemetrexed is the established standard of care.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e13ee9560851ca2fd4c44dfc1049c8
http://doc.rero.ch/record/303279/files/mdv101.pdf
http://doc.rero.ch/record/303279/files/mdv101.pdf