Zobrazeno 51 - 60
of 94
pro vyhledávání: '"Elaine Bignell"'
Autor:
Herbert N. Arst, Ana Maria Calcagno, Susana Negrete-Urtasun, Thomas R. Rogers, Elaine Bignell, Ken Haynes
Publikováno v:
Molecular Microbiology. 55:1072-1084
The ability of a pathogen to adapt to the host environment is usually required for the initiation of disease. Here we have investigated the importance of the Aspergillus nidulans PacC-mediated pH response in the pathogenesis of pulmonary aspergillosi
Autor:
Elaine Bignell, Herbert N. Arst, Ken Haynes, Thomas R. Rogers, Hubertus Haas, Claudia Kragl, Markus Schrettl, Chistoph Joechl
Publikováno v:
The Journal of Experimental Medicine
The ability to acquire iron in vivo is essential for most microbial pathogens. Here we show that Aspergillus fumigatus does not have specific mechanisms for the utilization of host iron sources. However, it does have functional siderophore-assisted i
Publikováno v:
Molecular Microbiology. 52:785-799
We have cloned and characterized the Aspergillus fumigatus cpcA gene encoding the transcriptional activator of the cross-pathway control system of amino acid biosynthesis. cpcA encodes a functional orthologue of Saccharomyces cerevisiae Gcn4p. The co
Autor:
Michael D. Jones, Ana-Maria Calcagno, Ken Haynes, Elaine Bignell, Fritz A. Mühlschlegel, Peter Warn, Thomas R. Rogers, David W. Denning
Publikováno v:
Molecular Microbiology. 50:1309-1318
The highly conserved fungal Ste12 transcription factor family of proteins play critical roles in the regulation of many cellular processes including mating, cell wall biosynthesis, filamentation and invasive growth. They are also important mediators
Autor:
Elaine Bignell
Reactive oxygen intermediates (ROIs), pH exacerbations, and calcium fluxes can act together to effect fungal killing at the level of the phagocyte; therefore, resilience in the face of rapid environmental alterations is necessary to promote fungal su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c922214e2c16cc382dc14d23c68d4a6
https://doi.org/10.1128/9781555815523.ch17
https://doi.org/10.1128/9781555815523.ch17
Autor:
Darius Armstrong-James, Maryam Safari, Hong Liu, Elaine Bignell, Markus Schrettl, Angela M. Cheverton, Carol A. Munro, Dan Chen, Alberto Muñoz, Natalie D. Fedorova, Shinobu Saijo, Louise A. Walker, Timothy C. Cairns, Susanne Herbst, Scott G. Filler, Margherita Bertuzzi, William C. Nierman, Hubertus Haas, Eduardo A. Espeso, Laura Alcazar-Fuoli, Nick D. Read
Publikováno v:
Bertuzzi, M; Schrettl, M; Alcazar-Fuoli, L; Cairns, TC; Muñoz, A; Walker, LA; et al.(2014). The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathogens, 10(10). doi: 10.1371/journal.ppat.1004413. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3tv284s0
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS pathogens, vol 10, iss 10
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 10, no. 10 . https://doi.org/10.1371/journal.ppat.1004413
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 11, no. 6, e1004943 . https://doi.org/10.1371/journal.ppat.1004413
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS pathogens, vol 10, iss 10
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 10, no. 10 . https://doi.org/10.1371/journal.ppat.1004413
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 11, no. 6, e1004943 . https://doi.org/10.1371/journal.ppat.1004413
20 p.-8 fig. Margherita Bertuzzi et alt.
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6448d726f776ee22968ded767e73646
http://www.escholarship.org/uc/item/3tv284s0
http://www.escholarship.org/uc/item/3tv284s0
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 371:20160023
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene clusters (BGC
Publikováno v:
Medical Mycology. :myw085
Aspergillus fumigatus is the most common airborne pathogen causing fatal mycoses in immunocompromised patients. During the first 8 hours of development A. fumigatus conidia break dormancy, expand isotopically, establish an axis of polarity, and begin
Autor:
Elaine Bignell
Publikováno v:
Expert Review of Anti-infective Therapy. 8:1333-1335
The 9th International Mycological Congress, hosted by the British Mycological Society and the International Mycological Association, attracted 1600 delegates from around the world. Among the many hundreds of submitted abstracts, plenary lectures and
Autor:
Elaine Bignell
Publikováno v:
Subtelomeres ISBN: 9783642415654
Understanding of Aspergillus subtelomere biology remains in its infancy but has recently come under closer scrutiny due to possible involvement in plant, human and animal virulence, and natural product biosynthesis. Comparative genomics of pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d6a789aa1edcc29abc09ce46daa18b
https://doi.org/10.1007/978-3-642-41566-1_6
https://doi.org/10.1007/978-3-642-41566-1_6