Zobrazeno 21 - 30
of 146
pro vyhledávání: '"Duncan T. Odom"'
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1319-1328.e6 (2020)
Cell Reports
Cell Reports
Summary Transcription factor binding to enhancer and promoter regions critical for homeostatic adult gene activation is established during development. To understand how cell-specific gene expression patterns are generated, we study the developmental
Autor:
Caesar Z. Li, Amin Haghani, Todd R. Robeck, Diego Villar, Ake T. Lu, Joshua Zhang, Chris G. Faulkes, Ha Vu, Julia Ablaeva, Danielle M. Adams, Reza Ardehali, Adriana Arneson, C. Scott Baker, Katherine Belov, Daniel T. Blumstein, Eleanor K. Bors, Charles E. Breeze, Robert T. Brooke, Janine L. Brown, Alex Caulton, Julie M. Cavin, Ioulia Chatzistamou, Hao Chen, Priscila Chiavellini, Oi-Wa Choi, Shannon Clarke, Joseph DeYoung, Candice K. Emmons, Stephan Emmrich, Zhe Fei, Steven H. Ferguson, Carrie J. Finno, Jennifer E. Flower, Jean-Michel Gaillard, Eva Garde, Vadim N. Gladyshev, Rodolfo G. Goya, M. Bradley Hanson, Martin Haulena, Kelsey Herrick, Andrew N. Hogan, Carolyn J. Hogg, Timothy A. Hore, Anna J. Jasinska, Gareth Jones, Eve Jourdain, Olga Kashpur, Harold Katcher, Etsuko Katsumata, Vimala Kaza, Hippokratis Kiaris, Michael S. Kobor, Pawel Kordowitzki, William R. Koski, Brenda Larison, Sang-Goo Lee, Marianne Lehmann, Jean-Francois Lemaitre, Andrew J. Levine, Cun Li, Xinmin Li, David TS Lin, Dana M. Lindemann, Nicholas Macoretta, Dewey Maddox, Craig O. Matkin, Julie A. Mattison, June Mergl, Jennifer J. Meudt, Gisele A. Montano, Khyobeni Mozhui, Asieh Naderi, Martina Nagy, Pritika Narayan, Peter W. Nathanielsz, Ngoc B. Nguyen, Christof Niehrs, Duncan T Odom, Alexander G. Ophir, Elaine A. Ostrander, Perrie O'Tierney Ginn, Kim M. Parsons, Kimberly C. Paul, Matteo Pellegrini, Gabriela M. Pinho, Jocelyn Plassais, Natalia A. Prado, Benjamin Rey, Beate R. Ritz, Jooke Robbins, Magdalena Rodriguez, Jennifer Russell, Elena Rydkina, Lindsay L. Sailer, Adam B. Salmon, Akshay Sanghavi, Kyle M. Schachtschneider, Dennis Schmitt, Lars Schomacher, Lawrence B. Schook, Karen E. Sears, Ashley W. Seifert, Anastasia V. Shindyapina, Kavita Singh, Ishani Sinha, Russel G. Snell, Elham Soltanmohammadi, Matthew L. Spangler, Maria Spriggs, Karen J. Steinman, Victoria J. Sugrue, Balazs Szladovits, Masaki Takasugi, Emma C. Teeling, Bill Van Bonn, Sonja C. Vernes, Harry V. Vinters, Mary C. Wallingford, Nan Wang, Gerald S. Wilkinson, Robert W. Williams, X. William Yang, Brent G. Young, Bohan Zhang, Zhihui Zhang, Peng Zhao, Yang Zhao, Wanding Zhou, Joseph A. Zoller, Jason Ernst, Andrei Seluanov, Ken Raj, Vera Gorbunova, Steve Horvath
Maximum lifespan of a species is the oldest that individuals can survive, reflecting the genetic limit of longevity in an ideal environment. Here we report methylation-based models that accurately predict maximum lifespan (r=0.89), gestational time (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fee697f5dd92102b3316fdd9b4d13a89
https://doi.org/10.1101/2021.05.16.444078
https://doi.org/10.1101/2021.05.16.444078
Autor:
Rozbeh Jafari, Anders Castor, Henrik Lilljebjörn, Duncan T. Odom, Mattias Vesterlund, Linda Olsson, Minjun Yang, Kajsa Paulsson, Naveen Ravi, Ioannis Siavelis, Eleanor L. Woodward, Janne Lehtiö, Louise Harewood, Larissa H. Moura-Castro, Thoas Fioretos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets
Autor:
Ye Zhan, Hongbo Yang, Lijun Zhang, William Stafford Noble, Dubravka Pezic, Victoria T. Le, Duncan T. Odom, Rajinder Kaul, David M. Gilbert, Christopher Pool, Ross C. Hardison, James R. Broach, Job Dekker, Suzana Hadjur, Vishnu Dileep, Darrin V. Bann, Jesse R. Dixon, Ferhat Ay, Tingting Liu, Yanli Wang, Jie Xu, Bryan R. Lajoie, Sriranga Iyyanki, Christina Ernst, John A. Stamatoyannopoulos, Michael Buckley, Abhijit Chakraborty, Juan Carlos Rivera-Mulia, Feng Yue, Takayo Sasaki, Kristen Lee, Royden A. Clark, Morgan Diegel, Lin An, Hakan Ozadam, Galip Gürkan Yardımcı, Fan Song
Publikováno v:
Nature Genetics. 50:1388-1398
Structural variants can contribute to oncogenesis through a variety of mechanisms. Despite their importance, the identification of structural variants in cancer genomes remains challenging. Here, we present a framework that integrates optical mapping
Autor:
Sarah J. Aitken, Christine Feig, Duncan T. Odom, Ximena Ibarra-Soria, Elissavet Kentepozidou, Klara Stefflova, Paul Flicek, Maša Roller
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Genome Biology
Genome Biology
Funder: European Molecular Biology Laboratory; doi: http://dx.doi.org/10.13039/100013060
Background: CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically asso
Background: CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5e206c8ab4674b51ddf82e597ab553
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-24 (2020)
BMC Biology
BMC Biology
Background The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and functional impact of evolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a27e3bca8e18f87ff59c5674dc5072b
https://www.repository.cam.ac.uk/handle/1810/328433
https://www.repository.cam.ac.uk/handle/1810/328433
Autor:
Jennifer Harrow, Duncan T. Odom, David Thybert, Paul Flicek, Thomas M. Keane, Adam Frankish, Ian T. Fiddes, Cristina Sisu, Mark Gerstein, Paul R. Muir, Tim Hubbard, Mark Diekhans
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pseudogenes are ideal markers of genome remodelling. In turn, the mouse is an ideal platform for studying them, particularly with the recent availability of strain-sequencing and transcriptional data. Here, combining both manual curation and automati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739d95c716655e85047b774f5f80af46
Autor:
Osagie G. Izuogu, Duncan T. Odom, Maša Roller, Paul Flicek, Ramachanderan R, Diego Villar, Aisling M. Redmond, Louise Harewood, Fergal J. Martin, Stamper E
SUMMARYTo investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in liver, brain, muscle, and testis from ten diverse mammals. The regulatory landscape around genes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e084ad5ad0ef08b685763d1e7cfce1a5
https://doi.org/10.1101/2020.05.31.126169
https://doi.org/10.1101/2020.05.31.126169
Autor:
Claire Cox, Menon Suraj, Brian Hendrich, Elisabete Nascimento, Duncan T. Odom, Stewart MacArthur, Michaela Frye, Matthew Trotter, Bernd Kübler, Salvador Aznar Benitah, Sandra Blanco, Shobbir Hussain, Jennifer Nichols
Publikováno v:
Nature cell biology
How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation complex, a locus essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b87e974b3d0685d8efcbed8fd9b025
Autor:
Diego Villar, Duncan T. Odom
Publikováno v:
Genome Medicine
A report on the meeting 'Functional Genomics and Systems Biology 2011', Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 29 November to 1 December, 2011.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad762dee99334b0727b39ff002f322b