Zobrazeno 71 - 80
of 194
pro vyhledávání: '"Dipanjan Chowdhury"'
Autor:
Dipanjan Chowdhury
Publikováno v:
Clinical Cancer Research. 26:IA03-IA03
High-grade serous ovarian carcinoma (HGSOC) patients with germline mutations in BRCA1/2 exhibit high sensitivity and improved outcome to platinum-based drugs and PARP inhibitors. Three PARP inhibitors (olaparib, rucaparib, niraparib) have recently ga
Autor:
Yinghui Zhou, Clarence Yapp, Doga Gulhan, Sandro Santagata, Julie R. Graham, Anniina Färkkilä, Dipanjan Chowdhury, Ursula A. Matulonis, Connor A. Jacobson, Alan D. D'Andrea, Yu-An Chen, Ana Lako, Sampsa Hautaniemi, Scott J. Rodig, Huy V. Nguyen, Peter K. Sorger, Pamela N. Munster, Denis Schapiro, Bose Kochupurakkal, Geoffrey I. Shapiro, Bruce J. Dezube, Zoltan Maliga, Elizabeth M. Swisher, Elizabeth P. Garcia, Panagiotis A. Konstantinopoulos, Julia Casado, Peter J. Park
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications
Nature Communications
Combined PARP and immune checkpoint inhibition has yielded encouraging results in ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling and highly multiplexed single-cell imaging on tumor samples from patients en
Autor:
Michelangelo Fiorentino, Ericka M. Ebot, Piotr Zareba, Richard Flavin, Lorelei A. Mucci, Carl Ceraolo, Andreas Pettersson, Stephen P. Finn, Konrad H. Stopsack, Meir J. Stampfer, Dipanjan Chowdhury, Travis Gerke, Philip W. Kantoff, Massimo Loda
Publikováno v:
Journal of Clinical Oncology. 38:65-65
65 Background: DNA repair genes including BRCA1 are commonly altered in metastatic prostate tumors. However, mutations and copy number aberrations in these genes are rare in primary tumors. Instead, preliminary studies suggest that higher tumor expre
Autor:
Alan D. D'Andrea, John G. Doench, David E. Root, Panagiotis A. Konstantinopoulos, Jean-Yves Masson, Gaëlle Legube, Dipanjan Chowdhury, Jessica Miller, Chunyu Yang, Subhojyoti De, Pascal Drané, Anchal Sharma, Marie-Christine Caron, Jie Bian, Khyati Meghani, Niraj Joshi, Yizhou Joseph He, Daryl A. Ronato, Alexandre Detappe
Publikováno v:
Clinical Cancer Research. 25:GMM-027
High-grade serous ovarian carcinoma (HGSOC) patients with germline mutations in BRCA1/2 exhibit high sensitivity and improved outcome to double strand DNA break (DSB)-inducing agents [i.e. platinum and Poly(ADP-ribose) polymerase inhibitors (PARPi)]
Autor:
Catarina Oliveira, Dipanjan Chowdhury, Nishita Parnandi, J. Ross Chapman, James R. Thompson, Benoît Bragantini, Gaofeng Cui, Maria Victoria Botuyan, Debiao Zhao, Alexandre Detappe, Shweta Chaubey, Georges Mer, Pascal Drané, Marie Eve Brault
Dynamic protein interaction networks such as DNA double-strand break (DSB) signaling are modulated by post-translational modifications (PTMs). The DNA repair factor 53BP1 is a rare example of a protein whose PTM binding function can be switched on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fe4c237e6413f1742a0c5b8650b051
https://doi.org/10.1038/s41594-018-0083-z
https://doi.org/10.1038/s41594-018-0083-z
Autor:
Adam C. Resnick, Sabine Mueller, Jing Ni, Whitney Fitts, Dipanjan Chowdhury, Xiaodong Yang, Sharmistha Pal, Pratiti Bandhopadhayay, John A. Alberta, Steven G. DuBois, Jean J. Zhao, David Kozono, Kevin X. Liu, Keith L. Ligon, Nathalene Truffaux, Jie Bian, William A. Weiss, Daphne A. Haas-Kogan
Pediatric high-grade gliomas (pHGGs) and diffuse intrinsic pontine gliomas (DIPGs), portend a poor prognosis and are particularly recalcitrant to standard treatment. Aberrant chromatin remodeling and activation of the phosphatidylinositol 3-kinase (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eec997719189bef6bb2a709aee65354
https://europepmc.org/articles/PMC6012600/
https://europepmc.org/articles/PMC6012600/
Autor:
Ioannis S. Pateras, Maria Chiourea, Dipanjan Chowdhury, Ioanna Mourkioti, Wojciech Fendler, Sophia V. Rizou, Aristides G. Eliopoulos, Sentiljana Gumeni, Eleni Paparouna, Ioannis P. Trougakos, Eric O’Neill, Christos P. Zampetidis, Vassilis G. Gorgoulis, Jiri Bartek, Eirini-Stavroula Komseli, Dafni-Eleftheria Pefani, Sarantis Gagos, Konrad Stawiski, Alexander Polyzos, Thorbjørn Krejsgaard, Fani-Marlen Roumelioti
Publikováno v:
Komseli, E, Pateras, I S, Krejsgaard, T, Stawiski, K, Rizou, S V, Polyzos, A, Roumelioti, F, Chiourea, M, Mourkioti, I, Paparouna, E, Zampetidis, C P, Gumeni, S, Trougakos, I P, Pefani, D, O’neill, E, Gagos, S, Eliopoulos, A G, Fendler, W, Chowdhury, D, Bartek, J & Gorgoulis, V G 2018, ' A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence ', BMC Genomics, vol. 19, no. 1 . https://doi.org/10.1186/s12864-017-4375-1
BMC Genomics, Vol 19, Iss 1, Pp 1-22 (2018)
BMC Genomics
Komseli, E S, Pateras, I S, Krejsgaard, T, Stawiski, K, Rizou, S V, Polyzos, A, Roumelioti, F M, Chiourea, M, Mourkioti, I, Paparouna, E, Zampetidis, C P, Gumeni, S, Trougakos, I P, Pefani, D E, O'Neill, E, Gagos, S, Eliopoulos, A G, Fendler, W, Chowdhury, D, Bartek, J & Gorgoulis, V G 2018, ' A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence ', BMC Genomics, vol. 19, no. 1, 37 . https://doi.org/10.1186/s12864-017-4375-1
BMC Genomics, Vol 19, Iss 1, Pp 1-22 (2018)
BMC Genomics
Komseli, E S, Pateras, I S, Krejsgaard, T, Stawiski, K, Rizou, S V, Polyzos, A, Roumelioti, F M, Chiourea, M, Mourkioti, I, Paparouna, E, Zampetidis, C P, Gumeni, S, Trougakos, I P, Pefani, D E, O'Neill, E, Gagos, S, Eliopoulos, A G, Fendler, W, Chowdhury, D, Bartek, J & Gorgoulis, V G 2018, ' A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence ', BMC Genomics, vol. 19, no. 1, 37 . https://doi.org/10.1186/s12864-017-4375-1
Background Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for ca
Autor:
Eirini-Stavroula Komseli, Pateras, Ioannis, Krejsgaard, Thorbjørn, Stawiski, Konrad, Rizou, Sophia, Polyzos, Alexander, Fani-Marlen Roumelioti, Chiourea, Maria, Mourkioti, Ioanna, Paparouna, Eleni, Zampetidis, Christos, Gumeni, Sentiljana, Trougakos, Ioannis, Dafni-Eleftheria Pefani, O’Neill, Eric, Gagos, Sarantis, Eliopoulos, Aristides, Fendler, Wojciech, Dipanjan Chowdhury, Jiri Bartek, Vassilis Gorgoulis
Enrichment plots a-b) of the “Cell cycle mitotic” and c-d) of the “DNA replication” gene-sets. Cells entering senescence (3-day induced) showed a significant (Bonferroni-adjusted p value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4974dc7e49bb19cea460be66c16075
Autor:
Luca Scorrano, George Pappas, Jiri Bartek, Vassilis L. Souliotis, Nicholas E. Geacintov, Umakanta Swain, Athanassios Kotsinas, Alexandros G. Georgakilas, Panagiotis Galanos, Dipanjan Chowdhury, Christina Glytsou, Ioannis S. Pateras, Zvi Livneh, Vassilis G. Gorgoulis, Zoi Lygerou, Jiri Lukas, Claudia Lukas, Alexander Polyzos, Claus Storgaard Sørensen, Nickolaos N. Giakoumakis, Ioanna Svolaki
Publikováno v:
Genome Biology
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Galanos, P, Pappas, G, Polyzos, A, Kotsinas, A, Svolaki, I, Giakoumakis, N N, Glytsou, C, Pateras, I S, Swain, U, Souliotis, V L, Georgakilas, A G, Geacintov, N, Scorrano, L, Lukas, C, Lukas, J, Livneh, Z, Lygerou, Z, Chowdhury, D, Sørensen, C S, Bartek, J & Gorgoulis, V G 2018, ' Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability ', Genome Biology (Online Edition), vol. 19, 37, pp. 1-18 . https://doi.org/10.1186/s13059-018-1401-9
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Galanos, P, Pappas, G, Polyzos, A, Kotsinas, A, Svolaki, I, Giakoumakis, N N, Glytsou, C, Pateras, I S, Swain, U, Souliotis, V L, Georgakilas, A G, Geacintov, N, Scorrano, L, Lukas, C, Lukas, J, Livneh, Z, Lygerou, Z, Chowdhury, D, Sørensen, C S, Bartek, J & Gorgoulis, V G 2018, ' Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability ', Genome Biology (Online Edition), vol. 19, 37, pp. 1-18 . https://doi.org/10.1186/s13059-018-1401-9
Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p2
Autor:
Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Nickolaos Giakoumakis, Glytsou, Christina, Pateras, Ioannis, Umakanta Swain, Vassilis Souliotis, Georgakilas, Alexandros, Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Jiri Lukas, Livneh, Zvi, Lygerou, Zoi, Dipanjan Chowdhury, SøRensen, Claus, Jiri Bartek, Vassilis Gorgoulis
Tables S1. to S4. (DOCX 71 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bbf81dc3c5787700038a53aea2b4ee