Zobrazeno 51 - 60
of 165
pro vyhledávání: '"Deric L. Wheeler"'
Autor:
Isa Mambetsariev, Xiwei Wu, Arin Nam, Deric L. Wheeler, Bolot Mambetsariev, Everett E. Vokes, Aliya N. Husain, Tamara Mirzapoiazova, Ravi Salgia, Valeriy Poroyko
Publikováno v:
Oncotarget
Lung cancer is a devastating disease with overall bleak prognosis. Current methods to diagnose lung cancer are rather invasive and are inadequate to detect the disease at an early stage when treatment is likely to be most effective. In this study, a
Autor:
Mari Iida, Deric L. Wheeler, Hannah E. Pearson, Randall J. Kimple, Rachel A. Orbuch, Nellie K. McDaniel, Kwangok P. Nickel, Jack L. Arbiser
Publikováno v:
Molecular Cancer Therapeutics. 17:204-214
Overexpression and activation of the EGFR have been linked to poor prognosis in several human cancers. Cetuximab is a mAb against EGFR that is used for the treatment in head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer. U
Autor:
Harsh Bahrar, John P. Coan, Toni M. Brand, Johan Lantto, Michael Kragh, Rachel A. Orbuch, Hannah E. Pearson, Deric L. Wheeler, Adam D. Swick, Mari Iida, Prashanth J. Prabakaran, Bailey Flanigan, Randall J. Kimple, Ivan D. Horak, Ravi Salgia
Publikováno v:
Molecular Cancer Therapeutics, 15, 2175-86
Molecular Cancer Therapeutics, 15, 9, pp. 2175-86
Molecular Cancer Therapeutics, 15, 9, pp. 2175-86
Cetuximab, an antibody against the EGFR, has shown efficacy in treating head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer, and non–small cell lung cancer (NSCLC). Despite the clinical success of cetuximab, many patients do
Autor:
Michael S. Nelson, Ka Ming Pang, Raju Pillai, Ravi Salgia, Jiale Wang, Amita Behal, Jiayi Liu, Prakash Kulkarni, Saumya Srivastava, Isa Mambetsariev, Arin Nam, Deric L. Wheeler, Atish Mohanty, Mari Iida, Nellie K. McDaniel
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101692-(2020)
iScience
iScience
Summary The tyrosine kinase receptor ephrin receptor A2 (EPHA2) is overexpressed in lung (LSCC) and head and neck (HNSCC) squamous cell carcinomas. Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 and
Autor:
Martin Schaller, Mahyar Abbariki, Ulrich Rothbauer, Julia Maier, Mari Iida, Sara Y Brucker, Corinna Kosnopfel, Paul M. Harari, Birgit Fehrenbacher, Mahmoud Toulany, Daniel Zips, Aadhya Tiwari, Deric L. Wheeler, Apostolos Menegakis, Birgit Schittek
Publikováno v:
Cancers, Vol 12, Iss 2795, p 2795 (2020)
Cancers
Volume 12
Issue 10
Cancers
Volume 12
Issue 10
Simple Summary Triple-negative breast cancer (TNBC) is associated with the high rates of relapse and metastasis and poor survival. YB-1 is overexpressed in TNBC tumor tissues. In the present study, we demonstrated that S102 phosphorylation of YB-1 in
Publikováno v:
Mutat Res
The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα), AKT2 (PKBβ) and AKT3 (PKBγ). The PI3K/AKT pathway is normally activated
Autor:
Kwangok P. Nickel, Jaimee C Eckers-Kubatzke, Prashanth J. Prabakaran, Tamara S. Rodems, Nellie K. McDaniel, Carlene A. Kranjac, Deric L. Wheeler, R.J. Kimple, Mari Iida, Adam D. Swick, Alison E. Schulz, Ravi Salgia, Noah B. Welke
Publikováno v:
Molecular Cancer Therapeutics. 18:A128-A128
Radiation and cetuximab are therapeutics used in the management of head and neck squamous cell carcinoma (HNSCC). Despite clinical success with these modalities, development of both intrinsic and acquired resistance is an emerging problem in the mana
High AXL Expression Predicts Worse Overall Survival and Locoregional Recurrence in Esophageal Cancer
Autor:
Stephen A. Rosenberg, Jacob S. Witt, Andrew M. Baschnagel, Darya Buehler, David T. Yang, Nellie K. McDaniel, Adam R. Burr, Justin C. Jagodinsky, Mari Iida, Deric L. Wheeler
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 105:S85
Autor:
Randall J. Kimple, Kwangok P. Nickel, Ravindra Uppaluri, Loren S. Michel, Anthony M. Robinson, Brian A. Van Tine, Douglas Adkins, Nathan J. Redlich, Deric L. Wheeler, Andrew P. Stein
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 1, Pp 1-12 (2018)
Cell Death and Disease, Vol 9, Iss 1, Pp 1-12 (2018)
ErbB3 has been widely implicated in treatment resistance, but its role as a primary treatment target is less clear. Canonically ErbB3 requires EGFR or ErbB2 for activation, whereas these two established treatment targets are thought to signal indepen
Autor:
Mari Iida, Rebecca E. Parker, Deborah DeRyckere, Justus Hulse, Christopher T. Cummings, Olivia J. Ondracek, Hannah E. Pearson, Randall J. Kimple, H. Shelton Earp, Douglas K. Graham, Paul M. Harari, Xiaodong Wang, Stephen V. Frye, Grace Hye-Hyun Kang, Nellie K. McDaniel, Kurtis D. Davies, Eleana Vasileiadi, Rachel A. Orbuch, Deric L. Wheeler, Noah B. Welke
Publikováno v:
Molecular cancer therapeutics. 17(11)
The TAM (TYRO3, AXL, MERTK) family receptor tyrosine kinases (RTK) play an important role in promoting growth, survival, and metastatic spread of several tumor types. AXL and MERTK are overexpressed in head and neck squamous cell carcinoma (HNSCC), t