Zobrazeno 81 - 90
of 191
pro vyhledávání: '"Denise D. Belsham"'
Autor:
Neelam Khaper, Fayez Dawood, Marty Straume, Denise D. Belsham, Horia Pribiag, Peter P. Liu, Michael J. Sole, Martin R. Ralph, Jennifer A. Chalmers, Nazneen Tata, Peter H. Backx, Paul Lee, Tami A. Martino
Publikováno v:
Hypertension. 49:1104-1113
Day/night rhythms are recognized as important to normal cardiovascular physiology and timing of adverse cardiovascular events; however, their significance in disease has not been determined. We demonstrate that day/night rhythms play a critical role
Publikováno v:
Neuroendocrinology. 85:232-241
Adipokines such as leptin, resistin, and fasting-induced adipose factor (FIAF) are secreted by adipocytes, but their expression is also detectable in the brain and pituitary. The role of central adipokines remains elusive, but we speculate that they
Publikováno v:
American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 308(5), R337-R350. American Physiological Society
The suprachiasmatic nucleus (SCN) in the mammalian hypothalamus functions as an endogenous pacemaker that generates and maintains circadian rhythms throughout the body. Next to this central clock, peripheral oscillators exist in almost all mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e993b63dd99e702a4c48d72b3d6cc4e7
https://pure.knaw.nl/portal/en/publications/46820966-fce0-4dd3-92a8-a7fdc04f193c
https://pure.knaw.nl/portal/en/publications/46820966-fce0-4dd3-92a8-a7fdc04f193c
Publikováno v:
Molecular Endocrinology. 20:2080-2092
Neuropeptide Y (NPY) and agouti-related peptide (AgRP) stimulate feeding, whereas NPY also facilitates the estrogen-mediated preovulatory GnRH surge. In addition to regulating reproductive function, estrogen also acts as an anorexigenic hormone, alth
Publikováno v:
The Journal of Neuroscience. 25:9497-9506
Neurotensin (NT) is implicated in the regulation of energy homeostasis, in addition to its many described physiological functions. NT is postulated to mediate, in part, the effects of leptin in the hypothalamus. We generated clonal, immortalized hypo
Autor:
Fang Cai, Marty Straume, Peter Liu, Tami A. Martino, Maria G. Trivieri, Michael J. Sole, Martin R. Ralph, Nazneen Tata, Sara Arab, Denise D. Belsham
Publikováno v:
Journal of Molecular Medicine. 82:256-264
Molecular circadian oscillators have recently been identified in heart and many other peripheral organs; however, little is known about the physiologic significance of circadian gene cycling in the periphery. While general temporal profiles of gene e
Autor:
Fang Cai, Lulzim Shkreta, Denise D. Belsham, Hong Cui, Anne Marie F. Salapatek, Simon R. Smukler
Publikováno v:
Endocrinology. 145:393-400
Knowledge of how the brain achieves its diverse central control of basic physiology is severely limited by the virtual absence of appropriate cell models. Isolation of clonal populations of unique peptidergic neurons from the hypothalamus will facili
Autor:
Deboleena Roy, Denise D. Belsham
Publikováno v:
Journal of Biological Chemistry. 277:251-258
Melatonin plays a significant role in the control of the hypothalamic-pituitary-gonadal axis. Using the GT1-7 cell line, an in vitro model of GnRH-secreting neurons of the hypothalamus, we examined the potential signal transduction pathways activated
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology, 307(8), R1049-R1060. American Physiological Society
Diets high in saturated fatty acids (SFAs) are associated with the development of circadian dysregulation, obesity, and Type 2 diabetes mellitus. Conversely, polyunsaturated fatty acids (PUFAs) have recently been identified to improve insulin sensiti
Publikováno v:
Frontiers in neuroendocrinology. 36
Attesting to its intimate peripheral connections, hypothalamic neurons integrate nutritional and hormonal cues to effectively manage energy homeostasis according to the overall status of the system. Extensive progress in the identification of essenti