Zobrazeno 31 - 40
of 80
pro vyhledávání: '"Davide Trotti"'
Autor:
Lauren Taylor Rosenblum, Davide Trotti
Publikováno v:
Advances in Neurobiology ISBN: 9783319557670
Amyotrophic lateral sclerosis (ALS) is a rapid and fatal neurodegenerative disease, primarily affecting upper and lower motor neurons. It is an extremely heterogeneous disease in both cause and symptom development, and its mechanisms of pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1368de5f48a1f0b4a7c07d52d84a72
https://europepmc.org/articles/PMC6668619/
https://europepmc.org/articles/PMC6668619/
Publikováno v:
Glia. 62:1241-1253
EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian central nervous system (CNS). Its dysfunction has been linked with many neurological disorders, including amyotrop
Publikováno v:
Journal of Neuroscience. 33:11588-11598
Mutations in superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis (ALS) in 20% of familial cases (fALS). Mitochondria are one of the targets of mutant SOD1 (mutSOD1) toxicity. We previously demonstrated that at the mitochondria, mutSOD1
Autor:
Hisham, Qosa, Jessica, Lichter, Mark, Sarlo, Shashirekha S, Markandaiah, Kevin, McAvoy, Jean-Philippe, Richard, Michael R, Jablonski, Nicholas J, Maragakis, Piera, Pasinelli, Davide, Trotti
Publikováno v:
Glia. 64(8)
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-g
Autor:
Piera Pasinelli, Mauro Ceroni, Elena Donetti, Davide Trotti, Daryl A. Bosco, Cristina Cereda, Stefania Guareschi, Emanuela Cova
Publikováno v:
Proceedings of the National Academy of Sciences. 109:5074-5079
Recent studies suggest that Cu/Zn superoxide dismutase (SOD1) could be pathogenic in both familial and sporadic amyotrophic lateral sclerosis (ALS) through either inheritable or nonheritable modifications. The presence of a misfolded WT SOD1 in patie
Autor:
Francesca Fieni, Piera Pasinelli, Jeff W. Lichtman, Thomas Misgeld, Davide Trotti, Martin Kerschensteiner, Anjum Parkar
Publikováno v:
Journal of Biological Chemistry. 285:27411-27417
Potassium fluxes integrate mitochondria into cellular activities, controlling their volume homeostasis and structural integrity in many pathophysiological mechanisms. The outer mitochondrial membrane (OMM) is thought to play a passive role in this pr
Autor:
Davide Trotti, Emily Foran
Publikováno v:
Antioxidants & Redox Signaling. 11:1587-1602
Responsible for the majority of excitatory activity in the central nervous system (CNS), glutamate interacts with a range of specific receptor and transporter systems to establish a functional synapse. Excessive stimulation of glutamate receptors cau
Autor:
Stuart L. Gibb, William Boston-Howes, Piera Pasinelli, Zeno Scotto Lavina, Robert H. Brown, Davide Trotti, Stefano Gustincich
Publikováno v:
Journal of Biological Chemistry. 282:32480-32490
EAAT2 (excitatory amino acid transporter 2) is a high affinity, Na+-dependent glutamate transporter of glial origin that is essential for the clearance of synaptically released glutamate and prevention of excitotoxicity. During the course of human am
Publikováno v:
Annals of the New York Academy of Sciences. 738:153-162
Autor:
Piera Pasinelli, Niels C. Danbolt, Masashi Aoki, Matthias A. Hediger, Urs V. Berger, Robert H. Brown, Davide Trotti
Publikováno v:
Journal of Biological Chemistry. 276:576-582
We have investigated the functional impact of a naturally occurring mutation of the human glutamate transporter GLT1 (EAAT2), which had been detected in a patient with sporadic amyotrophic lateral sclerosis. The mutation involves a substitution of th