Zobrazeno 101 - 110
of 160
pro vyhledávání: '"David G. Hoel"'
Autor:
Christopher J. Portier, David G. Hoel
Publikováno v:
Risk Analysis. 7:437-447
The TD50 (or tumorigenic dose rate 50) is a generally accepted measure of the carcinogenic potency of a chemical in a particular strain of animal. This paper discusses error in the estimation of the TD50 caused by intercurrent mortality and error res
Publikováno v:
Communications in Statistics - Theory and Methods. 6:777-788
A method is presented for the sequential analysis of experiments involving two treatments to which response is dichotomous. Composite hypotheses about the difference in success probabilities are tested, and covariate information is utilized in the an
Publikováno v:
Science. 219:1032-1037
Efforts in estimating carcinogenic risk in humans from long-term exposure to chemical carcinogens have centered on the problem of low-dose extrapolation. For chemicals with metabolites that interact with DNA, it may be more meaningful to relate tumor
Autor:
Takashi Yanagawa, David G. Hoel
Publikováno v:
Journal of the American Statistical Association. 81:1095-1099
The testing of chemicals for carcinogenic activity in lifetime rodent bioassays has produced a large amount of data on a few strains of mice and rats. Because of the use of fixed protocols in repeated experiments, the opportunity presents itself for
Autor:
David G. Hoel, Robert I. Jennrich
Publikováno v:
Journal of Statistical Computation and Simulation. 20:311-322
Life table analysis techniques in epidemiology depend upon the asymptotic properties of the statistical test methods employed. In some instances, the statistical procedures indicate highly significant results which are, in reality, unjustified. The p
Autor:
Kenny S. Crump, David G. Hoel
Publikováno v:
Biometrika. 61:237-252
SUMMARY A number of mathematical models for cell populations in which mutations are occurring are studied and compared by viewing the models as filtered Poisson processes. Based upon these models, a statistical analysis is given of the mutant accumul
Autor:
Kantilal M. Patel, David G. Hoel
Publikováno v:
Journal of the American Statistical Association. 68:615-620
A measure of interaction in factorial experiments is introduced and the problem of estimating it and testing it for nullity is considered. The asymptotic power efficiencies are studied and Monte Carlo power comparisons are made when samples are drawn
Publikováno v:
Journal of Statistical Computation and Simulation. 3:299-313
We consider the problem of choosing the best of k binomial populations when the time to response is non zero. Several sampling schemes are discussed, with an aim to making as few trials as possible with the poorer treatments, as would be a desideratu
Publikováno v:
Fundamental and Applied Toxicology. 5:79-86
In risk estimation, the results of rodent carcinogenesis experiments are often used to quantitatively predict effects in man. The justification for this approach has in large part been dependent upon the good correlation of carcinogenic potency found
Autor:
David G. Hoel, Takemi Yanagimoto
Publikováno v:
Annals of the Institute of Statistical Mathematics. 32:465-480
Procedures to estimate a dose of which the incidence probability is very small (e.g. 10−6) have been developed to evaluate the safety of chemical compounds. To compare models for estimation of safe doses quantitatively, a measure of the heaviness o