Zobrazeno 11 - 20
of 29
pro vyhledávání: '"David Flyer"'
Autor:
Richard W. Compans, Yasmine A. Gomaa, Chinglai Yang, Ling Ye, Mark R. Prausnitz, Jean L. Patterson, Gregory M. Glenn, Hua Wu, Fang Lin, Ricardo Carrion, David Flyer, Gale Smith, Ying Liu
Publikováno v:
The Journal of infectious diseases. 218(suppl_5)
In this study, we investigated immune responses induced by purified Ebola virus (EBOV) soluble glycoprotein (sGP) subunit vaccines via intradermal immunization with microneedle (MN) patches in comparison with intramuscular (IM) injection in mice. Our
Autor:
Mark R. Prausnitz, Ricardo Carrion, David Flyer, Jean L. Patterson, Fang Lin, Gregory M. Glenn, Richard W. Compans, Chinglai Yang, Ling Ye, Ying Liu, Yasmine A. Gomaa, Gale Smith, Hua Wu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Development of a safe and efficacious filovirus vaccine is of high importance to public health. In this study, we compared immune responses induced by Ebola virus (EBOV) glycoprotein (GP) subunit vaccines via intradermal immunization with microneedle
Autor:
D. Nigel Thomas, David Flyer, Eloi Kpamegan, Pedro A. Piedra, Dewal Jani, Somia P. Hickman, Gale Smith, Gregory M. Glenn, Hanxin Lu, Louis Fries
Publikováno v:
Journal of Infectious Diseases. 213:411-422
Background Respiratory syncytial virus (RSV) is a leading cause of infant morbidity and mortality. A recombinant RSV fusion protein nanoparticle vaccine (RSV F vaccine) candidate for maternal immunization was tested for safety and immunogenicity in w
Autor:
Hannah M. Creager, Michael J. Massare, Ye V. Liu, Min Z. Levine, Melissa B. Pearce, David Flyer, Gregory M. Glenn, Gale Smith, Peter Pushko, Yaohui Bai, Jessica A. Belser, Taronna R. Maines, Terrence M. Tumpey, Xiangjie Sun
Publikováno v:
Virology. 509
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian inf
Autor:
Irina Petrushina, David H. Cribbs, Hayk Davtyan, Lars Østergaard Pedersen, Anahit Ghochikyan, David Flyer, Jianmei Yu, Peter Juul Madsen, Michael G. Agadjanyan, Armine Hovakimyan
Publikováno v:
Journal of Neuroimmunology. 268:50-57
Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Es
Autor:
Ye V. Liu, Thiagarajan Venkataraman, Gregory M. Glenn, Matthew B. Frieman, Gale Smith, Christopher M. Coleman, David Flyer
Publikováno v:
Vaccine
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike
Autor:
Michael R. Holbrook, Hiroaki Matsushita, Matthew B. Frieman, Jonathan T. Wang, Eddie Sullivan, Ye Liu, Stanley Perlman, Hua Wu, Rudragouda Channappanavar, Reed F. Johnson, Gene G. Olinger, Kanakatte Raviprakash, Elena Postnikova, Lisa E. Hensley, Christopher M. Coleman, Tadeusz J. Kochel, Jincun Zhao, Britini L. Ork, Jin An Jiao, Gregory M. Glenn, Gale Smith, Wensheng Nie, Jens H. Kuhn, Thomas C. Luke, Gabriel Defang, David Flyer
Publikováno v:
Nature Reviews. Drug Discovery
As of 13 November 2015, 1618 laboratory-confirmed human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 579 deaths, had been reported to the World Health Organization. No specific preventive or therapeutic agent
Autor:
Steven R. Fuhrmann, Larry Ellingsworth, Stefanie Kluepfel-Stahl, Robert J. Carman, Jing-Hui Tian, David Flyer
Publikováno v:
Vaccine. 30:4249-4258
Antibodies targeting the Clostridium difficile toxin A and toxin B confer protective immunity to C. difficile associated disease in animal models and provided protection against recurrent C. difficile disease in human subjects. These antibodies are d
Autor:
Haifeng Song, Hanxin Lu, Ye Liu, Bin Zhou, Gregory M. Glenn, David Flyer, Jay W. Hooper, Karin Lövgren Bengtsson, Michael J. Massare, Ren Huan Xu, Gale Smith, Eloi Kpamegan, Steven A. Kwilas, Linda Stertman, Timothy J. Hahn, Ricardo Carrion
Publikováno v:
Vaccine. 34(16)
Ebola virus (EBOV) causes severe hemorrhagic fever for which there is no approved treatment or preventive vaccine. Immunological correlates of protective immunity against EBOV disease are not well understood. However, non-human primate studies have a
Autor:
David Flyer, Kimber L. Poffenberger, D. Nigel Thomas, Gregory M. Glenn, Bo H. Andersen, Larry Ellingsworth, Sarah A. Frech
Publikováno v:
Vaccine. 27:G60-G66
Background: The use of adjuvants to enhance the immune response to novel pandemic influenza vaccine candidates may overcome the poor immune responses seen in immunologically naive populations. The confluence of a highly pathogenic H5N1 influenza viru