Zobrazeno 11 - 20
of 48
pro vyhledávání: '"David Dilworth"'
Autor:
Christopher Daum, Kurt LaButti, Andrea Kuftin, Sara Calhoun, Shawn R. Starkenburg, Yuliya A. Kunde, Igor V. Grigoriev, Tisza Ann Szeremy Bell, Sirma Mihaltcheva, Lukas R. Dahlin, Katherine B. Louie, Benjamin P. Bowen, Michael T. Guarnieri, Trent R. Northen, David Dilworth, Daniel Treen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications biology, vol 4, iss 1
Communications Biology
Communications biology, vol 4, iss 1
Communications Biology
Microalgae efficiently convert sunlight into lipids and carbohydrates, offering bio-based alternatives for energy and chemical production. Improving algal productivity and robustness against abiotic stress requires a systems level characterization en
Publikováno v:
Biochemistry and Cell Biology. 98:42-49
FK506-binding proteins (FKBPs) alter the conformation of proteins via cis–trans isomerization of prolyl-peptide bonds. While this activity can be demonstrated in vitro, the intractability of detecting prolyl isomerization events in cells has limite
Autor:
David Dilworth
Publikováno v:
Overheard in Seville: Bulletin of the Santayana Society. 38:53-65
Autor:
Laia Carreté, Jan Breuer, Minou Nowrousian, Laura Sandor, Ramona Lütkenhaus, Kerrie Barry, David Dilworth, Jasmyn Pangilinan, Stefanie Pöggeler, Igor V. Grigoriev, Anna Lipzen, Toni Gabaldón, Stefanie Traeger, Alan Kuo
Publikováno v:
Genetics
Many filamentous ascomycetes develop three-dimensional fruiting bodies for production and dispersal of sexual spores. Fruiting bodies are among the most complex structures differentiated by ascomycetes; however, the molecular mechanisms underlying th
Autor:
Neda Savic, Joseph M Dobbs, Misha Bilenky, David Dilworth, Christopher J. Nelson, Martin Hirst, Shawn P. Shortill
Publikováno v:
Genetics
Gene duplications increase organismal robustness by providing freedom for gene divergence or by increasing gene dosage. The yeast histone chaperones Fpr3 and Fpr4 are paralogs that can assemble nucleosomes in vitro; however, the genomic locations the
Autor:
Jinrong Min, Matthew R. Marunde, Dmitri Kireev, Jack Greenblatt, Ferreira de Freitas R, Tigran M. Abramyan, Cheryl H. Arrowsmith, Peter Brown, Magda Szewczyk, Irene Chau, A. Dong, Kazemzadeh S, Dalia Barsyte-Lovejoy, Ronan P Hanley, Mengqi Zhou, Y. Liu, Michael-Christopher Keogh, Lindsey I. James, Edyta Marcon, Matthieu Schapira, David Dilworth, Ming Lei, Popova Ik, Albina Bolotokova, Marcus A. Cheek, Masoud Vedadi, Elisa Gibson, Suzanne Ackloo, Su Qin, Matthew J. Meiners, Nathan W. Hall, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li
NSD2 is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two PWWP and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4c6ef23b32f1b09d83b9d0588c0ec9
https://doi.org/10.1101/2021.03.05.433782
https://doi.org/10.1101/2021.03.05.433782
Autor:
Shadan H Abdali, Lifeng Liu, Robert B. Hutmacher, Kim K. Hixson, Tanya E. Winkler, Benjamin J. Cole, Christer Jansson, Julie A. Sievert, Ljiljana Paša-Tolić, Amir H. Ahkami, Mary Madera, Neha Malhan, Mowei Zhou, Joy Hollingsworth, Peggy G. Lemaux, Jeff Dahlberg, Judith A Owiti, David Dilworth
Histones belong to a family of highly conserved proteins in eukaryotes. They pack DNA into nucleosomes as functional units of chromatin. Post-translational modifications (PTMs) of histones, which are highly dynamic and can be added or removed by enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e5e6370dd82f69523d27f2c9d907d6
https://escholarship.org/uc/item/9h02d61k
https://escholarship.org/uc/item/9h02d61k
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Autor:
Udo Oppermann, Jian Jin, Catrine Johansson, Roland Schüle, Holger Greschik, Gillian Farnie, David Dilworth, Manfred Jung, Jing Liu, Dalia Barsyte-Lovejoy, Kwang-Su Park, Cheryl H. Arrowsmith, Paul Brennan, Nicolas Babault, Ludwig Seifert, Irene Chau, Masoud Vedadi, Johannes Bacher, Vincent Fagan, Yan Xiong, Fengling Li, Michael L Martini, Oleg Fedorov, Thomas Christott
Publikováno v:
Journal of Medicinal Chemistry. 62:8996-9007
By screening an epigenetic compound library, we identified that UNC0638, a highly potent inhibitor of the histone methyltransferases G9a and GLP, was a weak inhibitor of SPIN1 (spindlin 1), a methyllysine reader protein. Our optimization of this weak
Autor:
Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Jinrong Min, Ronan P Hanley, Rima Al-awar, Matthieu Schapira, Lindsey I. James, Renato Ferreira de Freitas, Magdalena M. Szewczyk, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li, Carlos Zepeda-Velázquez, Elisa Gibson, David McLeod, Yanli Liu, Peter Brown, David Dilworth
Publikováno v:
J Med Chem
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported to date. Here, we pr