Zobrazeno 71 - 80
of 155
pro vyhledávání: '"Danxin Wang"'
Autor:
Danxin Wang, Wolfgang Sadee
Publikováno v:
Pharmacogenetics and genomics. 26(1)
Cytochrome P450 3A4 (CYP3A4) metabolizes 30-50% of clinically used drugs. Large interperson variability in CYP3A4 activity affects response to CYP3A4 substrate drugs. We had demonstrated that an intronic single nucleotide polymorphism rs35599367 (CYP
Autor:
Deborah C. Mash, Danxin Wang, Wolfgang Sadee, Ryan M. Smith, Audrey C. Papp, Linda Duque, Robert A. Moyer
Publikováno v:
Neuropsychopharmacology. 36:753-762
The dopamine receptor D2 (encoded by DRD2) is implicated in susceptibility to mental disorders and cocaine abuse, but mechanisms responsible for this relationship remain uncertain. DRD2 mRNA exists in two main splice isoforms with distinct functions:
Autor:
Liang Li, Christopher Ting, Wolfgang Sadee, Jasmine A. Luzum, Edward L. Peterson, David E. Lanfear, Danxin Wang, Hongsheng Gui
Publikováno v:
Journal of Cardiac Failure. 24:S2
Introduction Protein kinase C α (PRKCA) is a fundamental regulator of beta-adrenergic signaling and cardiac contractility. Previous studies suggested that increased cardiac expression of PRKCA is associated with adverse cardiac outcomes. Cardiac exp
Autor:
Wolfgang Sadee, Houda Alachkar, Deborah C. Mash, Danxin Wang, Audrey C. Papp, Laura J. Bierut, Ryan M. Smith, Jen Chyong Wang
Publikováno v:
European Journal of Human Genetics. 19:76-83
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer. Previous studies demonstrate significant associations between promoter polymorphisms and CHRNA5 mRNA expression, but the re
Publikováno v:
The Pharmacogenomics Journal. 11:274-286
Cytochrome P450 3A4 (CYP3A4) metabolizes ~50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of genetic factors remains uncertain. In this study, we measured allelic CYP3A4 heteronuclear R
Autor:
Shan Naidu, Gustavo Leone, Wolfgang Sadee, Hui-Zi Chen, Paul C. Stromberg, Hui Wang, Matt Karikomi, Maysoon Rawahneh, Thomas J. Rosol, Charis Eng, Danxin Wang, Ravi Rajmohan, Julie A. Stephens, Michael Weinstein, Michael C. Ostrowski, Enrico Caserta, Krista M. D. La Perle, Julie Moffitt, Soledad Fernandez
Publikováno v:
Proceedings of the National Academy of Sciences. 107:5142-5147
Germline mutations in the tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden and Bannayan–Riley–Ruvalcaba (BRR) syndromes, two dominantly inherited disorders characterized by mental retardation, mul
Autor:
Marcello Nardini, Julia K. Pinsonneault, Wolfgang Sadee, Annabella Di Giorgio, Teresa Popolizio, Leonardo Fazio, Grazia Caforio, Giuseppe Blasi, Raffaella Romano, Audrey C. Papp, Paolo Taurisano, Antonio Rampino, Danxin Wang, Alessandro Bertolino
Publikováno v:
ResearcherID
Dopamine D2 receptor signalling is strongly implicated in the aetiology of schizophrenia. We have recently characterized the function of three DRD2 SNPs: rs12364283 in the promoter affecting total D2 mRNA expression; rs2283265 and rs1076560, respecti
Autor:
Wolfgang Sadee, Larisa H. Cavallari, Danxin Wang, Hui-Zi Chen, Kathryn M. Momary, Julie A. Johnson
Publikováno v:
Blood. 112:1013-1021
Warfarin dose requirements have been associated with 2 main haplotypes in VKORC1, but the responsible polymorphisms remain unknown. To search for regulatory polymorphisms, we measured allelic mRNA expression of VKORC1 in human liver, heart, and B lym
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:544-552
Opioid receptors display basal signaling (constitutive, agonist-independent activity), which seems to be regulated by agonist exposure. Whereas agonist pretreatment desensitizes receptors to subsequent agonist stimulation, basal signaling of mu-opioi
Autor:
Rong Lu, Michal Seweryn, Danxin Wang, Grzegorz A. Rempala, Amy Webb, Ryan M. Smith, Katherine Hartmann, Wolfgang Sadee
Publikováno v:
BMC Genomics
Background Measuring allele-specific RNA expression provides valuable insights into cis-acting genetic and epigenetic regulation of gene expression. Widespread adoption of high-throughput sequencing technologies for studying RNA expression (RNA-Seq)