Zobrazeno 101 - 110
of 729
pro vyhledávání: '"Daniel, H Geschwind"'
Autor:
Tawnie K. Silva, Daniel H. Geschwind, Alcino J. Silva, Miou Zhou, Andrey Rzhetsky, Sunrae Taloma, Stephanie A. White, Miranda Phan, Karen Bach, Isaiah Herrera, Gayle M. Boxx, Michael J. Gandal, Rochelle Mandanas, Ishanu Chattopadhyay, Elizabeth R. Fraley, Manuel F. López-Aranda, Genhong Cheng
Publikováno v:
Science advances, vol 7, iss 38
Science Advances
Science Advances
Description
Postnatal immune activation leads to social deficits in a mouse model of TSC by abnormal interferon production in microglia.
There is growing evidence that prenatal immune activation contributes to neuropsychiatric disorders. He
Postnatal immune activation leads to social deficits in a mouse model of TSC by abnormal interferon production in microglia.
There is growing evidence that prenatal immune activation contributes to neuropsychiatric disorders. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89792d2a5fc3bbdb66ecbcbb96846cd6
https://escholarship.org/uc/item/8kn0x9j9
https://escholarship.org/uc/item/8kn0x9j9
Autor:
Wei Zhou, Masahiro Kanai, Kuan-Han H. Wu, Humaira Rasheed, Kristin Tsuo, Jibril B. Hirbo, Ying Wang, Arjun Bhattacharya, Huiling Zhao, Shinichi Namba, Ida Surakka, Brooke N. Wolford, Valeria Lo Faro, Esteban A. Lopera-Maya, Kristi Läll, Marie-Julie Favé, Juulia J. Partanen, Sinéad B. Chapman, Juha Karjalainen, Mitja Kurki, Mutaamba Maasha, Ben M. Brumpton, Sameer Chavan, Tzu-Ting Chen, Michelle Daya, Yi Ding, Yen-Chen A. Feng, Lindsay A. Guare, Christopher R. Gignoux, Sarah E. Graham, Whitney E. Hornsby, Nathan Ingold, Said I. Ismail, Ruth Johnson, Triin Laisk, Kuang Lin, Jun Lv, Iona Y. Millwood, Sonia Moreno-Grau, Kisung Nam, Priit Palta, Anita Pandit, Michael H. Preuss, Chadi Saad, Shefali Setia-Verma, Unnur Thorsteinsdottir, Jasmina Uzunovic, Anurag Verma, Matthew Zawistowski, Xue Zhong, Nahla Afifi, Kawthar M. Al-Dabhani, Asma Al Thani, Yuki Bradford, Archie Campbell, Kristy Crooks, Geertruida H. de Bock, Scott M. Damrauer, Nicholas J. Douville, Sarah Finer, Lars G. Fritsche, Eleni Fthenou, Gilberto Gonzalez-Arroyo, Christopher J. Griffiths, Yu Guo, Karen A. Hunt, Alexander Ioannidis, Nomdo M. Jansonius, Takahiro Konuma, Ming Ta Michael Lee, Arturo Lopez-Pineda, Yuta Matsuda, Riccardo E. Marioni, Babak Moatamed, Marco A. Nava-Aguilar, Kensuke Numakura, Snehal Patil, Nicholas Rafaels, Anne Richmond, Agustin Rojas-Muñoz, Jonathan A. Shortt, Peter Straub, Ran Tao, Brett Vanderwerff, Manvi Vernekar, Yogasudha Veturi, Kathleen C. Barnes, Marike Boezen, Zhengming Chen, Chia-Yen Chen, Judy Cho, George Davey Smith, Hilary K. Finucane, Lude Franke, Eric R. Gamazon, Andrea Ganna, Tom R. Gaunt, Tian Ge, Hailiang Huang, Jennifer Huffman, Nicholas Katsanis, Jukka T. Koskela, Clara Lajonchere, Matthew H. Law, Liming Li, Cecilia M. Lindgren, Ruth J.F. Loos, Stuart MacGregor, Koichi Matsuda, Catherine M. Olsen, David J. Porteous, Jordan A. Shavit, Harold Snieder, Tomohiro Takano, Richard C. Trembath, Judith M. Vonk, David C. Whiteman, Stephen J. Wicks, Cisca Wijmenga, John Wright, Jie Zheng, Xiang Zhou, Philip Awadalla, Michael Boehnke, Carlos D. Bustamante, Nancy J. Cox, Segun Fatumo, Daniel H. Geschwind, Caroline Hayward, Kristian Hveem, Eimear E. Kenny, Seunggeun Lee, Yen-Feng Lin, Hamdi Mbarek, Reedik Mägi, Hilary C. Martin, Sarah E. Medland, Yukinori Okada, Aarno V. Palotie, Bogdan Pasaniuc, Daniel J. Rader, Marylyn D. Ritchie, Serena Sanna, Jordan W. Smoller, Kari Stefansson, David A. van Heel, Robin G. Walters, Sebastian Zöllner, Alicia R. Martin, Cristen J. Willer, Mark J. Daly, Benjamin M. Neale
Publikováno v:
Cell Genomics
Hayward, C, Campbell, A, Porteous, D J, Richmond, A & Marioni, R E 2022, ' Global Biobank Meta-analysis Initiative: powering genetic discovery across human disease ', Cell Genomics . https://doi.org/10.1016/j.xgen.2022.100192
Cell Genomics, 2(10):100192
Zhou, W, Kanai, M, Wu, K H H, Rasheed, H, Tsuo, K, Hirbo, J B, Wang, Y, Bhattacharya, A, Zhao, H, Namba, S, Surakka, I, Wolford, B N, Lo Faro, V, Lopera-Maya, E A, Läll, K, Favé, M J, Partanen, J J, Chapman, S B, Karjalainen, J, Kurki, M, Maasha, M, Brumpton, B M, Chavan, S, Chen, T T, Daya, M, Ding, Y, Feng, Y C A, Guare, L A, Gignoux, C R, Graham, S E, Hornsby, W E, Ingold, N, Ismail, S I, Johnson, R, Laisk, T, Lin, K, Lv, J, Millwood, I Y, Moreno-Grau, S, Nam, K, Palta, P, Pandit, A, Preuss, M H, Saad, C, Setia-Verma, S, Thorsteinsdottir, U, Uzunovic, J, Verma, A, Zawistowski, M, Loos, R J F, deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, Biobank of the Americas, BioBank Japan Project, BioMe, BioVU, CanPath-Ontario Health Study, China Kadoorie Biobank Collaborative Group & Colorado Center for Personalized Medicine 2022, ' Global Biobank Meta-analysis Initiative : Powering genetic discovery across human disease ', Cell Genomics, vol. 2, no. 10, 100192 . https://doi.org/10.1016/j.xgen.2022.100192
Hayward, C, Campbell, A, Porteous, D J, Richmond, A & Marioni, R E 2022, ' Global Biobank Meta-analysis Initiative: powering genetic discovery across human disease ', Cell Genomics . https://doi.org/10.1016/j.xgen.2022.100192
Cell Genomics, 2(10):100192
Zhou, W, Kanai, M, Wu, K H H, Rasheed, H, Tsuo, K, Hirbo, J B, Wang, Y, Bhattacharya, A, Zhao, H, Namba, S, Surakka, I, Wolford, B N, Lo Faro, V, Lopera-Maya, E A, Läll, K, Favé, M J, Partanen, J J, Chapman, S B, Karjalainen, J, Kurki, M, Maasha, M, Brumpton, B M, Chavan, S, Chen, T T, Daya, M, Ding, Y, Feng, Y C A, Guare, L A, Gignoux, C R, Graham, S E, Hornsby, W E, Ingold, N, Ismail, S I, Johnson, R, Laisk, T, Lin, K, Lv, J, Millwood, I Y, Moreno-Grau, S, Nam, K, Palta, P, Pandit, A, Preuss, M H, Saad, C, Setia-Verma, S, Thorsteinsdottir, U, Uzunovic, J, Verma, A, Zawistowski, M, Loos, R J F, deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, The QSkin Sun and Health Study, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, Biobank of the Americas, BioBank Japan Project, BioMe, BioVU, CanPath-Ontario Health Study, China Kadoorie Biobank Collaborative Group & Colorado Center for Personalized Medicine 2022, ' Global Biobank Meta-analysis Initiative : Powering genetic discovery across human disease ', Cell Genomics, vol. 2, no. 10, 100192 . https://doi.org/10.1016/j.xgen.2022.100192
Funding Information: The work of the contributing biobanks was supported by numerous grants from governmental and charitable bodies. Biobank-specific acknowledgments and more detailed acknowledgments are included in Data S2. Initiative management, S.
Autor:
Bin Tang, Tamara Seredenina, Giovanni Coppola, Alexandre Kuhn, Daniel H. Geschwind, Ruth Luthi-Carter, Elizabeth A. Thomas
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 459-467 (2011)
R6/2 transgenic mice with expanded CAG repeats (>300) have a surprisingly prolonged disease progression and longer lifespan than prototypical parent R6/2 mice (carrying 150 CAGs); however, the mechanism of this phenotype amelioration is unknown. We c
Externí odkaz:
https://doaj.org/article/77ba3a51fba8494b8b5956d5027c446f
Autor:
Oliver Wirths, Lena Spieth, Gesine Saher, Maik Thalmann, Christian Haass, Ting Sun, Takashi Saito, Klaus-Armin Nave, Riki Kawaguchi, Hannelore Ehrenreich, Daniel H. Geschwind, Sandra Göbbels, Stefan A. Berghoff, Takaomi C. Saido, Swati Subramanian, Andrew Octavian Sasmita, Ruth M. Stassart, Dilja Krueger-Burg, Michael Willem, Constanze Depp, Wiebke Möbius, Silvia Zampar, Agnes A. Steixner-Kumar
Publikováno v:
bioRxiv
The prevalence of Alzheimer’s disease (AD), the leading cause of dementia, shows a strict age-dependency, but why ageing constitutes the main risk factor for this disease is still poorly understood. Brain ageing affects oligodendrocytes1 and the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de9f611756da4b7663459ecd109f065
https://doi.org/10.1101/2021.07.31.454562
https://doi.org/10.1101/2021.07.31.454562
Autor:
Joel Mefford, Isabell Brickell, Andrew Dahl, Noah Zaitlen, Clare E. Palmer, Merete Nordentoft, Morteza Vaez, Daniel H. Geschwind, Terry L. Jernigan, Morten Krebs, Andrew J. Schork, Sonja LaBianca, Rebecca L. Walker, Vivek Appadurai, Marianne Giørtz Pedersen, Robert Loughnan, Ole Mors, Preben Bo Mortensen, Søren Dalsgaard, Jesper Gådin, Andres Ingason, Kenneth S. Kendler, Anders D. Børglum, Esben Agerbo, Dorte Helenius, David M. Hougaard, Thomas Werge
Attention deficit hyperactivity disorder (ADHD) is a complex disorder with heterogeneous clinical presentations that manifest variability in long-term outcomes. The genetic contributions to this clinical heterogeneity, however, are not well understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07397157058d5ab52ad53df77f60347
https://doi.org/10.21203/rs.3.rs-702232/v1
https://doi.org/10.21203/rs.3.rs-702232/v1
Autor:
Jing-Ping Lin, Hannah M. Kelly, Yeajin Song, Riki Kawaguchi, Daniel H. Geschwind, Steven Jacobson, Daniel S. Reich
Publikováno v:
Nature communications. 13(1)
To understand the cellular composition and region-specific specialization of white matter — a disease-relevant, glia-rich tissue highly expanded in primates relative to rodents — we profiled transcriptomes of ~500,000 nuclei from 19 tissue types
Autor:
Sonja LaBianca, Isabell Brikell, Dorte Helenius, Robert Loughnan, Joel Mefford, Clare E. Palmer, Rebecca Walker, Jesper R. Gådin, Morten Krebs, Vivek Appadurai, Morteza Vaez, Esben Agerbo, Marianne Gørtz Pedersen, Anders D. Børglum, David M. Hougaard, Ole Mors, Merete Nordentoft, Preben Bo Mortensen, Kenneth S. Kendler, Terry L. Jernigan, Daniel H. Geschwind, Andrés Ingason, Andrew W. Dahl, Noah Zaitlen, Søren Dalsgaard, Thomas M. Werge, Andrew J. Schork
Attention deficit hyperactivity disorder (ADHD) is a complex disorder with heterogeneous clinical presentations that manifest variability in long-term outcomes. The genetic contributions to this clinical heterogeneity, however, are not well understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090219ecf014ab8377d5ff05a41a8b3a
https://doi.org/10.1101/2021.07.13.21260299
https://doi.org/10.1101/2021.07.13.21260299
Autor:
Thomas E. Mahan, Deepti Lall, David M. Holtzman, Rita Sattler, A.K.M. Ghulam Muhammad, Michael Vazquez, Jesse Landeros, Daniel H. Geschwind, Hayk Davtyan, Ileana Lorenzini, Jacqueline G. O’Rourke, Jason D. Ulrich, Thomas A. Mota, Shaughn Bell, Junwon Kim, Jessica E. Rexach, Layla Ghaffari, Oksana Shelest, Mathew Blurton-Jones, Robert H. Baloh
Publikováno v:
Neuron, vol 109, iss 14
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31b1ab4973804c5e9402cb574f064cf
https://escholarship.org/uc/item/9ws7v673
https://escholarship.org/uc/item/9ws7v673
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
Yungui Zhou, Mercedes M, Maria Telpoukhovskaia, Sue-Ann Mok, Xinyue Chen, Li Gan, Konrad C, Manfredi G, Chao Wang, Timothy S. Chang, Martin J, Sweetland-Martin L, Erica Stevenson, Nevan J. Krogan, Ruth Huttenhain, Peter Dongmin Sohn, Kauwe G, Giovanni Coppola, Michael E. Ward, Madero-Pérez J, Daniel H. Geschwind, Danielle L. Swaney, Tracy Te, Michelle Moritz, Sang-Won Min
SUMMARYTau (MAPT) drives neuronal dysfunction in Alzheimer’s disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303a9fc9607f6dbfc63168365dd49ee3
https://doi.org/10.1101/2021.06.17.448349
https://doi.org/10.1101/2021.06.17.448349