Zobrazeno 11 - 20
of 144
pro vyhledávání: '"Chun-Xia Yi"'
Autor:
Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induce
Externí odkaz:
https://doaj.org/article/6cf55e31e14747279bd3ace341933215
Autor:
Paul de Goede, Ewout Foppen, Wayne I. G. R. Ritsema, Nikita L. Korpel, Chun-Xia Yi, Andries Kalsbeek
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Epidemiological studies indicate that shift-workers have an increased risk of type 2 diabetes mellitus (T2DM). Glucose tolerance and insulin sensitivity both are dependent on the circadian timing system (i.e., the time-of-day) and fasting duration, i
Externí odkaz:
https://doaj.org/article/e116fa88f1ac479fad0f4b2df7f40fc7
Autor:
Irina V. Milanova, Martin J. T. Kalsbeek, Xiao-Lan Wang, Nikita L. Korpel, Dirk Jan Stenvers, Samantha E. C. Wolff, Paul de Goede, Annemieke C. Heijboer, Eric Fliers, Susanne E. la Fleur, Andries Kalsbeek, Chun-Xia Yi
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Background: Disturbance of immunometabolic signaling is a key process involved in the progression of obesity. Microglia—the resident immune cells in the brain, initiate local immune responses. It is known that hypercaloric diets lead to microglial
Externí odkaz:
https://doaj.org/article/9d5af995e15f4f25884f0cf183a35366
Autor:
Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDA
Externí odkaz:
https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe2
Autor:
Xue Yang, Yong Wang, Qiyan Li, Yaxian Zhong, Liangpei Chen, Yajun Du, Jing He, Lvshuang Liao, Kun Xiong, Chun-xia Yi, Jie Yan
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the accurate mechanism of toxic effect of the drug on central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/de5f5150f2874230a911346c9fd8b7b4
Autor:
Zhuoran Yin, Divya D. Raj, Wandert Schaafsma, Roel A. van der Heijden, Susanne M. Kooistra, Aaffien C. Reijne, Xiaoming Zhang, Jill Moser, Nieske Brouwer, Peter Heeringa, Chun-Xia Yi, Gertjan van Dijk, Jon D. Laman, Erik W. G. M. Boddeke, Bart J. L. Eggen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Rodent models of both aging and obesity are characterized by inflammation in specific brain regions, notably the corpus callosum, fornix, and hypothalamus. Microglia, the resident macrophages of the central nervous system, are important for brain dev
Externí odkaz:
https://doaj.org/article/5c32f625dbc44c8e89f5c3303c573f98
Autor:
Jessica Mühlhaus, Juliane Dinter, Daniela Nürnberg, Maren Rehders, Maren Depke, Janine Golchert, Georg Homuth, Chun-Xia Yi, Silke Morin, Josef Köhrle, Klaudia Brix, Matthias Tschöp, Gunnar Kleinau, Heike Biebermann
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 11, Pp 20638-20655 (2014)
The thyroid hormone derivative 3-iodothyronamine (3-T1AM) exerts metabolic effects in vivo that contradict known effects of thyroid hormones. 3-T1AM acts as a trace amine-associated receptor 1 (TAAR1) agonist and activates Gs signaling in vitro. Inte
Externí odkaz:
https://doaj.org/article/01d32e6a0fb248879446d52ba27bc108
Autor:
Eugenia Morselli, Esther Fuente-Martin, Brian Finan, Min Kim, Aaron Frank, Cristina Garcia-Caceres, Carlos Rodriguez Navas, Ruth Gordillo, Michael Neinast, Sarada P. Kalainayakan, Dan L. Li, Yuanqing Gao, Chun-Xia Yi, Lisa Hahner, Biff F. Palmer, Matthias H. Tschöp, Deborah J. Clegg
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 633-645 (2014)
High-fat diets (HFDs) lead to obesity and inflammation in the central nervous system (CNS). Estrogens and estrogen receptor α (ERα) protect premenopausal females from the metabolic complications of inflammation and obesity-related disease. Here, we
Externí odkaz:
https://doaj.org/article/b4cf46e62bb6462dac0a3f392070fea3
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 5, Pp 686-690 (2012)
SUMMARY The mediobasal hypothalamic arcuate nucleus (ARC), with its relatively ‘leaky’ blood-brain barrier that allows more circulating molecules to enter the brain, has emerged as a key sensor of blood-borne signals. In both the ARC and white ad
Externí odkaz:
https://doaj.org/article/980aeb9179a2459cb9796f52a892b85e
Autor:
Chun-Xia Yi, Matthias H. Tschöp
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 5, Pp 583-587 (2012)
One of the ‘side effects’ of our modern lifestyle is a range of metabolic diseases: the incidence of obesity, type 2 diabetes and associated cardiovascular diseases has grown to pandemic proportions. This increase, which shows no sign of reversin
Externí odkaz:
https://doaj.org/article/19498534e5fc47539e38604e9b18ae42