Zobrazeno 31 - 34
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pro vyhledávání: '"Chrystal Paulos"'
Autor:
Shilpak Chatterjee, Pravin Kesarwani, Krishnamurthy Thyagarajan, Myroslawa Soloshchenko, Christine Webster, Chrystal Paulos, Shikhar Mehrotra
Publikováno v:
The Journal of Immunology. 192:205.7-205.7
Amongst various effector CD4+ T cells, T helper (Th)-17 subsets hold promise in adoptive T cell transfer therapy for cancer. However, ex vivo programming of Th17 cells in presence of TGF-β increases cell surface expression of ectonucleotidases CD39
Publikováno v:
The Journal of Immunology. 190:170.26-170.26
Human CD4+ T cells can differentiate into multiple effector subsets, but their role in anti-tumor immunity remains incompletely elucidated. Further, the costimulatory molecules that effectively bolster their antitumor activity are unknown. To uncover
Autor:
Mark Rubinstein, Caitlin Moore, Ee Su, Neizel Songalia, Daniel Neitzke, Colleen Cloud, C. Johnson, Chrystal Paulos, David Cole
Publikováno v:
The Journal of Immunology. 190:117.12-117.12
Effective T cell therapy against metastatic cancer requires high frequencies of functional tumor-reactive T cells. However, achieving sustained and elevated levels of tumor-reactive T cells has proven difficult and usually requires highly toxic preco
Publikováno v:
The Journal of Immunology. 188:46.29-46.29
TH17 cells play an essential role in regulating host defense and exacerbating various autoimmune diseases, but their role in tumor immunity remains incompletely elucidated. We found that CD28 abrogates TH17 expansion and function, while the inducible
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