Zobrazeno 31 - 40
of 935
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 899 (2020)
Resistance to β-lactam antibacterials, importantly via production of β-lactamases, threatens their widespread use. Bicyclic boronates show promise as clinically useful, dual-action inhibitors of both serine- (SBL) and metallo- (MBL) β-lactamases.
Externí odkaz:
https://doaj.org/article/6ecf02233cc14718992028bf8aa429eb
Autor:
Rebecca S. Dickinson, Fiona Murphy, Catherine Doherty, Sam Williams, Ananda Mirchandani, Joseph Willson, John S. Scotti, Gail Preston, Christopher J. Schofield, Moira K.B. Whyte, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Background: Pseudomonas species are adapted to evade innate immune responses and can persist at sites of relative tissue hypoxia, including the mucus-plugged airways of patients with cystic fibrosis and bronchiectasis. The ability of these bacteria t
Externí odkaz:
https://doaj.org/article/fac93a15831840aaafb87d14139b467b
Autor:
Christopher J. Schofield
Publikováno v:
IUCrJ, Vol 5, Iss 4, Pp 373-374 (2018)
Externí odkaz:
https://doaj.org/article/affd258bae534da49046613cf04c21e6
A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy
Autor:
Xin Shen, Natalie L. Voets, Sarah J. Larkin, Nick de Pennington, Puneet Plaha, Richard Stacey, James S. O. McCullagh, Christopher J. Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux-Hudson, Olaf Ansorge, Uzay E. Emir
Publikováno v:
Metabolites, Vol 9, Iss 2, p 35 (2019)
The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acids, and fatty acid metabolism. Mutations in isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high levels of 2-hydr
Externí odkaz:
https://doaj.org/article/04a0766963134ee09a4052a8fc49502a
Autor:
Suat Cheng Tan, Renata S. M. Gomes, Kar Kheng Yeoh, Filippo Perbellini, Sophia Malandraki-Miller, Lucy Ambrose, Lisa C. Heather, Giuseppe Faggian, Christopher J. Schofield, Kay E. Davies, Kieran Clarke, Carolyn A. Carr
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising candidate cell source for infarcted myocardium regeneration. However, current protocols used to expand CDCs require at least 1 month in vitro to obtain suff
Externí odkaz:
https://doaj.org/article/49b7d846cf104520ba3cf4554d037903
Autor:
Emily M. Harris, Jonathan D. Strope, Shaunna L. Beedie, Phoebe A. Huang, Andrew K. L. Goey, Kristina M. Cook, Christopher J. Schofield, Cindy H. Chau, Melissa M. Cadelis, Brent R. Copp, Kirk R. Gustafson, William D. Figg
Publikováno v:
Marine Drugs, Vol 16, Iss 7, p 241 (2018)
Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism
Externí odkaz:
https://doaj.org/article/d95ebade53c845c4a7d6092fce254125
Autor:
Sarah E. Wilkins, Md. Saiful Islam, Joan M. Gannon, Suzana Markolovic, Richard J. Hopkinson, Wei Ge, Christopher J. Schofield, Rasheduzzaman Chowdhury
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained an error in the spelling of the author Md. Saiful Islam, which was incorrectly given as Saiful Islam. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/52d660f70eeb46f8af6ebefa43ee2477
Autor:
Timothy Searls, Danica Butler, Winnie Chien, Mridul Mukherji, Matthew D. Lloyd, Christopher J. Schofield
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 8, Pp 1660-1667 (2005)
The mature form of phytanoyl-coenzyme A 2-hydroxylase (PAHX), a nonheme Fe(II)- and 2-oxoglutarate-dependent oxygenase, catalyzes the α-hydroxylation of phytanoyl-CoA within peroxisomes. Mutations in PAHX result in some forms of adult Refsum's disea
Externí odkaz:
https://doaj.org/article/60cef5c4d0704254935a7959317f6b02
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 3, Pp o593-o594 (2012)
The title compound, C7H13NO3, adopts an approximately planar conformation. The torsion angles in the aliphatic chain between the carbonyl group C atoms range from 172.97 (14) to 179.38 (14)° and the r.m.s. deviation of all non-H atoms is 0.059 Å. T
Externí odkaz:
https://doaj.org/article/601d9a16234142baa955e1b7137065c3
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 3, Pp o595-o595 (2012)
In the title compound, C4H10NO2+·Cl−, the central ethylene bond of the cation adopts a gauche conformation. The three H atoms of the –NH3+ group are engaged in strong and highly directional intermolecular N—H...Cl hydrogen bonds, which result
Externí odkaz:
https://doaj.org/article/719a86670f5744aab21bfcc76e3db491