Zobrazeno 71 - 80
of 86
pro vyhledávání: '"Christine Dierks"'
Autor:
Laurent Brault, Rebekka Grundler, Vanda Pogacic, Juerg Schwaller, Justus Duyster, G. Berridge, Christelle Gasser, Antonello Villa, Christine Dierks, Stefan Knapp, Tobias Dechow, Sabine Woetzel, Anke Spoo, Andrea Biondi, Alex N. Bullock, Sabine Ehret
Publikováno v:
The Journal of Experimental Medicine
FLT3-ITD–mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD–mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d43b6e0eb2aef17a5b7dc88a50d2fa
http://hdl.handle.net/10281/18542
http://hdl.handle.net/10281/18542
Autor:
Rebekka Grundler, Anke Spoo, Alec Bullock, Laurent Brault, Sabine Woetzel, Sabine Ehret, Tobias Dechow, Stefan Knapp, Martjin Nawijn, Andrea Biondi, Juerg Schwaller, Justus Duyster, G. Berridge, Christelle Gasser, Christine Dierks
Publikováno v:
BLOOD. 112(11)
Previous work has shown that FLT3-ITD mediated leukemogenesis is associated with increased expression of PIM1 and PIM2 serine/threonine kinases. Here we show that retroviral expression of FLT3-ITD could not compensate impaired clonogenic in vitro gro
Autor:
Paul W. Manley, Ronak Beigi, Gui-Rong Guo, Klemens Landwerlin, Christopher Trussell, Markus Warmuth, Mario R. Stegert, Hendrik Veelken, Annette Schmitt-Graeff, Katja Zirlik, Christine Dierks
Publikováno v:
Cancer cell. 14(3)
SummaryResistance of Bcr-Abl-positive leukemic stem cells (LSCs) to imatinib treatment in patients with chronic myeloid leukemia (CML) can cause relapse of disease and might be the origin for emerging drug-resistant clones. In this study, we identifi
Autor:
Justus Duyster, Konrad Aumann, Christine Dierks, Sandra Kissel, Tilman Brummer, Tony Andreas Müller, H Jumaa, Dimitri Belenki, Clara Sprissler, Dietmar Pfeifer, J Alexandrovski, J Hülsdünker, H Maurer, Claudius Klein
Publikováno v:
Blood Cancer Journal
The spleen tyrosine kinase (SYK) was identified as an oncogenic driver in a broad spectrum of hematologic malignancies. The in vivo comparison of three SYK containing oncogenes, SYK(wt), TEL-SYK and IL-2-inducible T-cell kinase (ITK)-SYK revealed a g
Autor:
Tilman Brummer, Christine Dierks, Niuscha Yaktapour, Dietmar Pfeifer, Hendrik Veelken, Katja Zirlik, Hassan Jumaa
Publikováno v:
Blood. 122:4121-4121
Chronic lymphocytic leukemia (CLL) remains incurable with current state of the art therapy creating the need for novel therapeutic concepts. Kinase inhibitors represent a promising strategy in the treatment of various malignancies including CLL. Howe
Autor:
Niuscha Yaktapour, Christine Dierks, Hassan Jumaa, Dietmar Pfeifer, Meike Burger, Rudolf Uebelhart, Tilman Brummer, Hendrik Veelken, Katja Zirlik
Publikováno v:
Blood. 120:3864-3864
Abstract 3864 Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of monoclonal B lymphocytes. For decades, nucleoside analogs, alkylating agents, and immunotherapeutics have remained the mainstay in treating this disease. Despite
Publikováno v:
Blood. 120:1310-1310
Abstract 1310 The spleen tyrosin kinase (SYK) was shown to be overexpressed in various human hematologic malignancies like B-cell lymphomas and acute myeloid leukemias. There are two known translocations involving the SYK kinase: ITK-SYK and TEL-SYK.
Publikováno v:
Blood. 120:3867-3867
Abstract 3867 Introduction: CXCR4 surface expression is strongly elevated on CLL cells and is important for CLL cell survival and homing to the bone marrow. PIM kinases are overexpressed and mutated in various hematologic malignancies including B-cel
Autor:
Ariane Ott, Natalie Stickel, Marcus Duehren-von Minden, Christine Dierks, Maike Buchner, Hassan Jumaa, Hendrik Veelken, Arlette Dörffel, Katja Zirlik
Publikováno v:
Blood. 118:800-800
Abstract 800 Chronic Lymphocytic Leukemia (CLL) is characterized by an accumulation of mature monoclonal B cells in the blood, secondary lymphoid tissue, and marrow. The highly variable prognosis of the disease may be predicted using a number of biom
Autor:
Hassan Jumaa, Jens Timmer, Maike Buchner, Gabriele Prinz, Kilian Bartholomé, Christine Dierks, Simon Wolfgang Fuchs, Nina Chevalier, John G. Gribben, Laurent Vallat, Hendrik Veelken, Katja Zirlik, Dietmar Pfeifer
Publikováno v:
ResearcherID
B cell chronic lymphocytic leukemia (CLL), the most prevalent B cell malignancy in adults, is characterized by expansion of monoclonal mature B lymphocytes. Despite advances in treatment, the disease remains incurable warranting further efforts to id