Zobrazeno 41 - 50
of 119
pro vyhledávání: '"Christian Gaiddon"'
Autor:
Yingying Wang, Mengfei Yao, Isabelle Gross, Linjing Li, Yue Li, Huimin Zou, Yu Liang, Liming Zhu, Xiaoling Weng, Yichao Hou, Danxi Zhu, Lei Li, Christian Gaiddon, Yan Gu, Xin Huang, Yu Wang, Lidan Hou, Xiangjun Meng, Tianqi Wu, Jianhua Wang, Meng Luo
Publikováno v:
Oncogene
Oncogene, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
Oncogene, Nature Publishing Group, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
Oncogene, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
Oncogene, Nature Publishing Group, 2019, Epub ahead of print]. ⟨10.1038/s41388-019-1035-8⟩
The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metabolic diseases; here, DCA was assayed to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37942441fd75783b1dd71fd339aa129
https://www.hal.inserm.fr/inserm-02364194/document
https://www.hal.inserm.fr/inserm-02364194/document
Autor:
Shireen Jozi, Jason R. Smith, Ryan M. Clarke, Christian Gaiddon, Jeffrey J. Warren, Tim Storr, Jessica J. Miller, Anais Blanchet, Christophe Orvain
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
Chemistry-A European Journal, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (67), pp.17734-17742. ⟨10.1002/chem.201802677⟩
International audience; The p53 protein plays a major role in cancer prevention, and over 50 % of cancer diagnoses can be attributed to p53 malfunction. The common p53 mutation Y220C causes local protein unfolding, aggregation, and can result in a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272afda3c0914f96547ca96b5aac60ec
http://summit.sfu.ca/item/19848
http://summit.sfu.ca/item/19848
Autor:
Maria V. Babak, Wee Han Ang, Mun Juinn Chow, Giorgia Pastorin, Daniel Yuan Qiang Wong, Christian Gaiddon
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
Molecular Pharmaceutics, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (7), pp.2543-2554. ⟨10.1021/acs.molpharmaceut.6b00348⟩
International audience; p53 is a key tumor suppressor gene involved in key cellular processes and implicated in cancer therapy. However, it is inactivated in more than 50% of all cancers due to mutation or overexpression of its negative regulators. T
Autor:
Jorge Andrés Solís-Ruiz, Anaïs Barthe, Rafael Omar Saavedra-Díaz, Ronan Le Lagadec, Christian Gaiddon, Gilles Riegel
Publikováno v:
Journal of Inorganic Biochemistry
Journal of Inorganic Biochemistry, Elsevier, 2020, 208, pp.111080. ⟨10.1016/j.jinorgbio.2020.111080⟩
Journal of Inorganic Biochemistry, Elsevier, 2020, 208, pp.111080. ⟨10.1016/j.jinorgbio.2020.111080⟩
Polypyridyl ruthenium complexes have been intensively investigated for their remarkable antiproliferative properties and some are currently being tested in clinical trials. Here, we investigated the impact of illumination on the biological properties
Autor:
Gianni Sava, Alain C. Jung, Pierre Coliat, Ricardo Cerón-Camacho, Cynthia Licona, Ronan Le Lagadec, Jean-Noël Freund, Moussa Ali, Eric Guérin, Christian Gaiddon, Vania Vidimar, Aina Venkatasamy, Dominique Guenot, Michel Pfeffer, Georg Mellitzer
Publikováno v:
Cancer Letters
Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Cancer Letters, Elsevier, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Cancer Letters, Elsevier, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
International audience; Targeting specific tumor metabolic needs represents an actively investigated therapeutic strategy to bypass tumor resistance mechanisms. In this study, we describe an original approach to impact the cancer metabolism by exploi
Autor:
Christian G. Hartinger, Maria S. Legina, Samuel M. Meier-Menches, Cynthia Licona, Michael A. Jakupec, Sarah Theiner, Muhammad Hanif, Michaela Hejl, Martin Pfaffeneder-Kmen, Bernhard K. Keppler, Christophe Orvain, Maria V. Babak, Christian Gaiddon
Publikováno v:
Inorganic Chemistry
Inorganic Chemistry, American Chemical Society, 2018, 57 (5), pp.2851-2864. ⟨10.1021/acs.inorgchem.7b03210⟩
Inorganic Chemistry, 2018, 57 (5), pp.2851-2864. ⟨10.1021/acs.inorgchem.7b03210⟩
Inorganic Chemistry, American Chemical Society, 2018, 57 (5), pp.2851-2864. ⟨10.1021/acs.inorgchem.7b03210⟩
Inorganic Chemistry, 2018, 57 (5), pp.2851-2864. ⟨10.1021/acs.inorgchem.7b03210⟩
We thank Prof. Markus Galanski for providing Pt precursors.; International audience; Platinum-based anticancer coordination compounds are widely used in the treatment of many tumor types, where they are very effective but also cause severe side effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dea6d18bea763c68583c9bbb48697a
https://www.hal.inserm.fr/inserm-02364163/file/acs.inorgchem.7b03210.pdf
https://www.hal.inserm.fr/inserm-02364163/file/acs.inorgchem.7b03210.pdf
Autor:
Kwan Wei Tan, Mun Juinn Chow, Mei Chi Cheong, Christian Gaiddon, Wee Han Ang, Giorgia Pastorin, Maria V. Babak
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, American Chemical Society, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
Molecular Pharmaceutics, American Chemical Society, 2018, 15 (8), pp.3020-3031. ⟨10.1021/acs.molpharmaceut.8b00003⟩
International audience; Current anticancer drug discovery efforts focus on the identification of first-in-class compounds with a mode-of-action distinct from conventional DNA-targeting agents for chemotherapy. An emerging trend is the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127630819ea87a98410b91db57739f58
https://www.hal.inserm.fr/inserm-02364152/document
https://www.hal.inserm.fr/inserm-02364152/document
Publikováno v:
Abdominal Radiology
Abdominal Radiology, 2018, 43 (10), pp.2888-2889. ⟨10.1007/s00261-018-1544-x⟩
Abdominal Radiology, Springer, 2018, 43 (10), pp.2888-2889. ⟨10.1007/s00261-018-1544-x⟩
Abdominal Radiology, 2018, 43 (10), pp.2888-2889. ⟨10.1007/s00261-018-1544-x⟩
Abdominal Radiology, Springer, 2018, 43 (10), pp.2888-2889. ⟨10.1007/s00261-018-1544-x⟩
International audience; no abstract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b54f14f00b9fdab9c869042bb25b1d
https://doi.org/10.1007/s00261-018-1544-x
https://doi.org/10.1007/s00261-018-1544-x
Autor:
Christophe Orvain, Michel Pfeffer, Adel Hamada, Moussa Ali, Jennifer Weckbach, Houda Habbita, Christian Gaiddon
Publikováno v:
Journal of Organometallic Chemistry
Journal of Organometallic Chemistry, Elsevier, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
Journal of Organometallic Chemistry, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
Journal of Organometallic Chemistry, Elsevier, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
Journal of Organometallic Chemistry, 2017, 845, pp.206-212. ⟨10.1016/j.jorganchem.2017.05.022⟩
International audience; Two novel cycloruthenated compounds, 2 and 3, derived from cycloruthenated 2-phenyl pyridine(Ru(PhPy)) have been synthesized by adding one equivalent of 2,20;60,200-terpyridine (terpy) to [Ru(2-C6H4-20-C5H4N-kC,N)(MeCN)4]PF6 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48050abfb0f582d9cbe6bd6832ddaa0
https://www.hal.inserm.fr/inserm-02365254/file/1-s2.0-S0022328X17303182-main.pdf
https://www.hal.inserm.fr/inserm-02365254/file/1-s2.0-S0022328X17303182-main.pdf
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2017, 8 (5), pp.3641-3649. ⟨10.1039/c7sc00497d⟩
Chemical Science, 2017, 8 (5), pp.3641-3649. ⟨10.1039/c7sc00497d⟩
Chemical Science, The Royal Society of Chemistry, 2017, 8 (5), pp.3641-3649. ⟨10.1039/c7sc00497d⟩
Chemical Science, 2017, 8 (5), pp.3641-3649. ⟨10.1039/c7sc00497d⟩
Phenotypic screening on a library of combinatorial self-assembled organoruthenium complexes revealed constructs that act on refractory cancers via apoptosis-independent pathways.
Multidrug resistance is a major impediment to chemotherapy and lim
Multidrug resistance is a major impediment to chemotherapy and lim