Zobrazeno 41 - 50
of 94
pro vyhledávání: '"Carol A. de la Motte"'
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
International Journal of Cell Biology
International Journal of Cell Biology
Hyaluronan is an extracellular glycosaminoglycan polymer consisting of linear disaccharide units containing alternating glucuronate and N-acetylglucosamine. Many cell types make hyaluronan, which unlike most other macromolecules is assembled at the p
Autor:
Sean P. Kessler, Carol A. de la Motte
Publikováno v:
International Journal of Cell Biology
International Journal of Cell Biology, Vol 2015 (2015)
International Journal of Cell Biology, Vol 2015 (2015)
Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this
Autor:
Andrew T. Schuster, Emily Deutschman, Jacqueline R. Kemp, Eleni Stylianou, Maria Hatzoglou, Brian P. Rubin, Claudio Fiocchi, Carol A. de la Motte, Christine McDonald, Michelle S. Longworth, Tammy Sadler, Yeojung Kim, Dawid Krokowski, Gail West, Kourtney P. Nickerson, Craig R. Homer
Publikováno v:
Gastroenterology. 148(7)
Background & Aims Defects in colonic epithelial barrier defenses are associated with ulcerative colitis (UC). The proteins that regulate bacterial clearance in the colonic epithelium have not been completely identified. The Drosophila chromosome-asso
Publikováno v:
Methods in Molecular Biology ISBN: 9781493917136
During inflammation and developmental processes, heavy chains (HCs) from inter-α-inhibitor (IαI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG- 6) to form a HC-HA complex. In this manuscri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34d158e6a696743a0fab7cfe28d3dd0
https://doi.org/10.1007/978-1-4939-1714-3_42
https://doi.org/10.1007/978-1-4939-1714-3_42
Autor:
Carol A. de la Motte, Anthony J. Day
Publikováno v:
Trends in Immunology. 26:637-643
Production of the glycosaminoglycan hyaluronan is increased at sites of inflammation, often correlating with the accumulation of leukocytes. Mounting evidence suggests that this polysaccharide can be organized into a wide variety of molecular archite
Renal Proximal Tubular Epithelial Cell Transforming Growth Factor-β1 Generation and Monocyte Binding
Autor:
Vincent C. Hascall, Aled O. Phillips, Wisam Dhafir Rashid Selbi, Xiao Liang Zhang, Carol A. de la Motte
Publikováno v:
The American Journal of Pathology. 165:763-773
With increasing awareness of the importance of renal cortical interstitial fibrosis, interest has focused on the mechanisms that stimulate generation of profibrotic factors including transforming growth factor (TGF)-beta1, by resident cells, such as
Autor:
Alana K. Majors, Vincent C. Hascall, Stephen P. Evanko, Thomas N. Wight, Judith A. Drazba, Aimin Wang, Scott A. Strong, Carol A. de la Motte
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1673:3-12
A variety of obstacles have hindered the ultrastructural localization of hyaluronan (HA). These include a lack of adequate fixation techniques to prevent the loss of HA, the lack of highly sensitive and specific probes, and a lack of accessibility du
Publikováno v:
Journal of the American Society of Nephrology. 15:1199-1211
Increased synthesis of hyaluronan (HA) in the renal corticointerstitium has been documented in renal injury, although the functional significance of this is unclear. The aim of the work presented in the current study was to examine the role of HA in
Publikováno v:
The American Journal of Gastroenterology. 99:938-945
Both Crohn's disease (CD) and ulcerative colitis (UC) are associated with abnormalities of platelet number and function. In the peripheral circulation the state of platelet activation is typically increased, and inflammatory bowel disease (IBD)-invol
Autor:
Silvio Danese, Claudio Fiocchi, Alan D. Levine, Miquel Sans, Brenda M Rivera Reyes, Carol A. de la Motte
Publikováno v:
The Journal of Immunology. 172:2011-2015
Platelets, in addition to exerting hemostatic activity, contribute to immunity and inflammation. The recent report that platelets express CD40 led us to hypothesize that CD40 ligand (CD40L)-positive T cells could bind to platelets, cause their activa