Zobrazeno 101 - 110
of 156
pro vyhledávání: '"Brian T. Layden"'
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1864(6 Pt)
Glutamine, a well-established oncometabolite, anaplerotically fuels mitochondrial energy metabolism and modulates activity of mammalian/mechanistic target of rapamycin complexes (mTOR). Currently, mTOR inhibitors are in clinical use for certain types
Autor:
Raghavendra G. Mirmira, Medha Priyadarshini, Charles R. Mackay, Thierry Alquier, Annette Gilchrist, Helena Mancebo, Barton Wicksteed, Vincent Poitout, Miles Fuller, Stephanie R. Villa, Brian T. Layden
Publikováno v:
Molecular Endocrinology. 29:1055-1066
G protein-coupled receptors have been well described to contribute to the regulation of glucose-stimulated insulin secretion (GSIS). The short-chain fatty acid-sensing G protein-coupled receptor, free fatty acid receptor 2 (FFAR2), is expressed in pa
Autor:
Timothy E. Reddy, William L. Lowe, Barton Wicksteed, Brian T. Layden, Anton E. Ludvik, Anthony R. Angueira
Publikováno v:
Diabetes
Pregnancy presents a unique physiological challenge that requires changes coordinated by placentally and non–placentally derived hormones to prepare the mother for the metabolic stress presented by fetal development and to ensure appropriate nutrie
Autor:
Lorna M. Dickson, Barton Wicksteed, Kelly Kaihara, Johanne H. Ellenbroek, Brian T. Layden, Caitlin M.D. Orr
Publikováno v:
Diabetes
Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic p
Publikováno v:
Clinical Diabetes : A Publication of the American Diabetes Association
Patients who are critically ill can develop acute insulin resistance manifesting as hyperglycemia and hyperinsulinemia. Rarely, patients can develop extreme insulin resistance, defined as having an insulin requirement of >3 units/kg/day (1). We repor
Autor:
Elin Chorell, Lara R. Dugas, Guichan Cao, Amy Luke, Richard S. Cooper, Tommy Olsson, Jacob Plange-Rhule, Brian T. Layden, Denise Scholten, Estelle V. Lambert, Julia H. Goedecke
Publikováno v:
Metabolomics : Official journal of the Metabolomic Society. 12(3)
In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and rela
Autor:
Brian T. Layden, Alexandra L. Thomas, Medha Priyadarshini, Jami L. Josefson, Denise M. Scholtens, Anna C. Reisetter, Thomas M.S. Wolever
Publikováno v:
Translational Research. 164:153-157
During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation,
Publikováno v:
Current and Future Developments in Physiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef1919df23469b0f79a0a235e4caa13e
https://doi.org/10.2174/9781681083650116010009
https://doi.org/10.2174/9781681083650116010009
Autor:
Manel Ben Aissa, Brian T. Layden, Gregory R. J. Thatcher, Wasim Khan, Bhargava Karumudi, Mary Jo LaDu, Sue H. Lee, Cutler T. Lewandowski
Publikováno v:
Alzheimer's & Dementia. 15:P268-P268
Autor:
Medha Priyadarshini, Anthony R. Angueira, Maureen Gannon, Sarah A. Tersey, Miles Fuller, Bethany A. Carboneau, Tanya Bhardwaj, Annette Gilchrist, Raghavendra G. Mirmira, Rockann E. Mosser, Brian T. Layden, Michael R. Brodsky, Stephanie R. Villa, Helena Mancebo
Publikováno v:
Scientific Reports
The regulation of pancreatic β cell mass is a critical factor to help maintain normoglycemia during insulin resistance. Nutrient-sensing G protein-coupled receptors (GPCR) contribute to aspects of β cell function, including regulation of β cell ma