Zobrazeno 31 - 40
of 1 046
pro vyhledávání: '"Bart Staels"'
Autor:
Guillaume Grzych, Oscar Chávez-Talavera, Amandine Descat, Dorothée Thuillier, An Verrijken, Mostafa Kouach, Vanessa Legry, Hélène Verkindt, Violeta Raverdy, Benjamin Legendre, Robert Caiazzo, Luc Van Gaal, Jean-Francois Goossens, Réjane Paumelle, Sven Francque, François Pattou, Joel T. Haas, Anne Tailleux, Bart Staels
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100222- (2021)
Background & Aims: Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabete
Externí odkaz:
https://doaj.org/article/86f4e08dfca4419c8dc1e4b25ab23c55
Autor:
Daniel Margerie, Philippe Lefebvre, Violeta Raverdy, Uwe Schwahn, Hartmut Ruetten, Philip Larsen, Alain Duhamel, Julien Labreuche, Dorothée Thuillier, Bruno Derudas, Céline Gheeraert, Hélène Dehondt, Quentin Dhalluin, Jérémy Alexandre, Robert Caiazzo, Pamela Nesslany, Helene Verkindt, François Pattou, Bart Staels
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecula
Externí odkaz:
https://doaj.org/article/9dfc1476bb6445368598bcee1cad784b
Autor:
Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blum
Publikováno v:
Neurobiology of Disease, Vol 125, Iss , Pp 14-22 (2019)
Accumulation of hyper-phosphorylated and aggregated Tau proteins is a neuropathological hallmark of Alzheimer's Disease (AD) and Tauopathies. AD patient brains also exhibit insulin resistance. Whereas, under normal physiological conditions insulin si
Externí odkaz:
https://doaj.org/article/1e5dc71246064ca998b489ffffebbd64
Autor:
Antonio Molinaro, Robert Caesar, Laurent L'homme, Ara Koh, Marcus Ståhlman, Bart Staels, Fredrik Bäckhed
Publikováno v:
Molecular Metabolism, Vol 23, Iss , Pp 82-87 (2019)
Objectives: The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an importa
Externí odkaz:
https://doaj.org/article/5fba586f534c4a26a0920342b16cbb9f
Autor:
Ning Liang, Anastasius Damdimopoulos, Saioa Goñi, Zhiqiang Huang, Lise-Lotte Vedin, Tomas Jakobsson, Marco Giudici, Osman Ahmed, Matteo Pedrelli, Serena Barilla, Fawaz Alzaid, Arturo Mendoza, Tarja Schröder, Raoul Kuiper, Paolo Parini, Anthony Hollenberg, Philippe Lefebvre, Sven Francque, Luc Van Gaal, Bart Staels, Nicolas Venteclef, Eckardt Treuter, Rongrong Fan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.
Externí odkaz:
https://doaj.org/article/90508a91d07f4ebf99f099ffd68ebc8f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5303 (2022)
Transcatheter aortic valve replacement (TAVR), as an alternative to open heart surgery, has revolutionized the treatment of severe aortic valve stenosis (AVS), the most common valvular disorder in the elderly. AVS is now considered a form of atherosc
Externí odkaz:
https://doaj.org/article/240f5d3227614192a16aa89c85113277
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101092- (2020)
Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients. NAFLD and CVD share several common risk factors including obesi
Externí odkaz:
https://doaj.org/article/ad81825d081d4b7aa17124e5719ea2e2
Autor:
Ben Arpad Kappel, Lorenzo De Angelis, Michael Heiser, Marta Ballanti, Robert Stoehr, Claudia Goettsch, Maria Mavilio, Anna Artati, Omero A. Paoluzi, Jerzy Adamski, Geltrude Mingrone, Bart Staels, Remy Burcelin, Giovanni Monteleone, Rossella Menghini, Nikolaus Marx, Massimo Federici
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: The metabolic influence of gut microbiota plays a pivotal role in the pathogenesis of cardiometabolic diseases. Antibiotics affect intestinal bacterial diversity, and long-term usage has been identified as an independent risk factor for at
Externí odkaz:
https://doaj.org/article/a0e5b75576b6472ab0441a9728f0b1a5
Autor:
Vanessa Dubois, Céline Gheeraert, Wouter Vankrunkelsven, Julie Dubois‐Chevalier, Hélène Dehondt, Marie Bobowski‐Gerard, Manjula Vinod, Francesco Paolo Zummo, Fabian Güiza, Maheul Ploton, Emilie Dorchies, Laurent Pineau, Alexis Boulinguiez, Emmanuelle Vallez, Eloise Woitrain, Eric Baugé, Fanny Lalloyer, Christian Duhem, Nabil Rabhi, Ronald E van Kesteren, Cheng‐Ming Chiang, Steve Lancel, Hélène Duez, Jean‐Sébastien Annicotte, Réjane Paumelle, Ilse Vanhorebeek, Greet Van den Berghe, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 5, Pp n/a-n/a (2020)
Abstract Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration. We demonstrate that this involves particularly profound transcriptomic alterations where acute induction of genes involved in handling of endopla
Externí odkaz:
https://doaj.org/article/25e5ed41e1224b8fae474a62d14c30b5
Autor:
Alicia Mayeuf-Louchart, David Hardy, Quentin Thorel, Pascal Roux, Lorna Gueniot, David Briand, Aurélien Mazeraud, Adrien Bouglé, Spencer L. Shorte, Bart Staels, Fabrice Chrétien, Hélène Duez, Anne Danckaert
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Background Skeletal muscle has the capacity to adapt to environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images of immunostained skeletal mus
Externí odkaz:
https://doaj.org/article/4b52aeac96e74cdd83237d7552ff6d85