Zobrazeno 21 - 30
of 1 046
pro vyhledávání: '"Bart Staels"'
Autor:
Benjamin Deckmyn, Dorothée Domenger, Chloé Blondel, Sarah Ducastel, Emilie Nicolas, Emilie Dorchies, Emilie Caron, Julie Charton, Emmanuelle Vallez, Benoit Deprez, Jean-Sébastien Annicotte, Sophie Lestavel, Anne Tailleux, Christophe Magnan, Bart Staels, Kadiombo Bantubungi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis in peripheral organs. Indeed, enterohepatic-expressed FXR controls metabolic processes (BA, glucose and lipid metabolism, fat mass, bo
Externí odkaz:
https://doaj.org/article/a3af6d005d634d79ae9036c03fc6ed79
Autor:
Oihane Garcia-Irigoyen, Fabiola Bovenga, Marilidia Piglionica, Elena Piccinin, Marica Cariello, Maria Arconzo, Claudia Peres, Paola Antonia Corsetto, Angela Maria Rizzo, Marta Ballanti, Rossella Menghini, Geltrude Mingrone, Philippe Lefebvre, Bart Staels, Takuji Shirasawa, Carlo Sabbà, Gaetano Villani, Massimo Federici, Antonio Moschetta
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103707- (2022)
Summary: Compelling evidence support an involvement of oxidative stress and intestinal inflammation as early events in the predisposition and development of obesity and its related comorbidities. Here, we show that deficiency of the major mitochondri
Externí odkaz:
https://doaj.org/article/e7c465e903a54134a3062ef2ac8d1993
Autor:
Kay H. M. Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, Esther Phielix, Bas Havekes, Yvonne M. H. Bruls, Martijn C. G. J. Brouwers, Marcus Ståhlman, Marjan Alssema, Harry P. F. Peters, Renée de Mutsert, Bart Staels, Marja-Riitta Taskinen, Jan Borén, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use 1H-MRS methodology to show hepatic SFA fraction is a measure o
Externí odkaz:
https://doaj.org/article/2c9a2f8b1cf44a76b5b73a890bc8f73e
Autor:
Ana Sandoval‐Rodriguez, Hugo Christian Monroy‐Ramirez, Alejandra Meza‐Rios, Jesus Garcia‐Bañuelos, Jose Vera‐Cruz, Jorge Gutiérrez‐Cuevas, Jorge Silva‐Gomez, Bart Staels, Jose Dominguez‐Rosales, Marina Galicia‐Moreno, Monica Vazquez‐Del Mercado, Jose Navarro‐Partida, Arturo Santos‐Garcia, Juan Armendariz‐Borunda
Publikováno v:
Hepatology Communications, Vol 4, Iss 3, Pp 434-449 (2020)
Nonalcoholic steatohepatitis (NASH) is recognized by hepatic lipid accumulation, inflammation, and fibrosis. No studies have evaluated the prolonged‐release pirfenidone (PR‐PFD) properties on NASH features. The aim of this study is to evaluate ho
Externí odkaz:
https://doaj.org/article/4d14eaa986de4f12ad1273fbf1608c98
Autor:
Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet, Nicolas Lebegue
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 524-538 (2020)
A series of nitrogen heterocycles containing α–ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-one was the most toler
Externí odkaz:
https://doaj.org/article/675e141641d84b13babe4e8932ee3515
Autor:
Tim van Zutphen, Johanna H.M. Stroeve, Jiufang Yang, Vincent W. Bloks, Angelika Jurdzinski, Han Roelofsen, Nicolette C.A. Huijkman, Theo H. van Dijk, Roel J. Vonk, Jan van Deursen, Bart Staels, Albert K. Groen, Folkert Kuipers
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1547-1561 (2019)
The bile acid-activated nuclear receptor, FXR (NR1H4), has been implicated in the control of lipid and energy metabolism, but its role in fat tissue, where it is moderately expressed, is not understood. In view of the recent development of FXR-target
Externí odkaz:
https://doaj.org/article/8840b252e57a440b90ac25aad4d7f14e
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100658- (2021)
Summary: Here, we describe an optimized protocol to identify specific nuclear receptor ligands. First, to rule out any compound interference with luciferase activity per se, we describe an in vitro assay assessing potential inhibition or activation o
Externí odkaz:
https://doaj.org/article/6498ddec6e6e48ffa201ea011d3f785c
Autor:
Ángela del Castillo-Izquierdo, José María Moreno-Navarrete, Jessica Latorre, María Arnoriaga-Rodríguez, Marta Ballanti, Giovanni Monteleone, Omero Alessandro Paoluzi, Geltrude Mingrone, Josep Puig, Rafael Ramos, Josep Garre-Olmo, Mariona Jové, Reinald Pamplona, Manuel Portero-Otín, Joaquim Sol, Philippe Lefebvre, Bart Staels, Massimo Federici, José Manuel Fernández-Real, Jordi Mayneris-Perxachs
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2177 (2022)
Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is known to bind nucleic acids wit
Externí odkaz:
https://doaj.org/article/ca7a7aa43585444bb2cd8f18b4ed149b
Autor:
Francisco Sáez-Orellana, Thomas Leroy, Floriane Ribeiro, Anna Kreis, Karelle Leroy, Fanny Lalloyer, Eric Baugé, Bart Staels, Charles Duyckaerts, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Among genetic susceptibility loci associated with late-onset Alzheimer disease (LOAD), genetic polymorphisms identified in genes encoding lipid carriers led to the hypothesis that a disruption of lipid metabolism could promote disease progression. We
Externí odkaz:
https://doaj.org/article/e8a9b89247db4df9868a05e462a785d5
Autor:
Justine Gillard, Corinne Picalausa, Christoph Ullmer, Luciano Adorini, Bart Staels, Anne Tailleux, Isabelle A. Leclercq
Publikováno v:
Nutrients, Vol 14, Iss 13, p 2707 (2022)
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major health concern with no approved pharmacological therapies. Molecules developed to activate the bile acid-receptor TGR5 regulate pathways involved in MALFD pathogenesis, but the t
Externí odkaz:
https://doaj.org/article/e894aea60f524f7586ce70cd39ceb4c9