Zobrazeno 81 - 90
of 455
pro vyhledávání: '"Balázs Győrffy"'
Autor:
Jesús Fuentes-Antrás, Ana Lucía Alcaraz-Sanabria, Esther Cabañas Morafraile, María del Mar Noblejas-López, Eva María Galán-Moya, Mariona Baliu-Pique, Igor López-Cade, Vanesa García-Barberán, Pedro Pérez-Segura, Aránzazu Manzano, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña
Publikováno v:
Cancers, Vol 13, Iss 4, p 833 (2021)
The dysregulation of post-translational modifications (PTM) transversally impacts cancer hallmarks and constitutes an appealing vulnerability for drug development. In breast cancer there is growing preclinical evidence of the role of ubiquitin and ub
Externí odkaz:
https://doaj.org/article/91516469a33a45a89150e646ebce6ec6
Autor:
Lei Zhu, Ke-Jia Kan, Johanna L. Grün, Barbara Hissa, Cui Yang, Balázs Győrffy, Sonja Loges, Christoph Reißfelder, Sebastian Schölch
Publikováno v:
Cancers, Vol 12, Iss 12, p 3774 (2020)
Pancreatic cancer is a malignant disease with high mortality and a dismal prognosis. Circulating tumor cell (CTC) detection and characterization have emerged as essential techniques for early detection, prognostication, and liquid biopsy in many soli
Externí odkaz:
https://doaj.org/article/a70eef0339264d68a494a711b633be49
Publikováno v:
Cancers, Vol 13, Iss 1, p 63 (2020)
Introduction: Squamous cell carcinomas (SCC) are a major subgroup of malignant tumors with a platinum-based first-line systematic chemotherapy. miRNAs play a role in various diseases and modulate therapy response as well. The aim of this study was to
Externí odkaz:
https://doaj.org/article/4a4e5059889b4a7ab8c06606088eb10e
Autor:
Andreas E. Moor, Pascale Anderle, Claudio Cantù, Patrick Rodriguez, Norbert Wiedemann, Frédérique Baruthio, Jürgen Deka, Sylvie André, Tomas Valenta, Matthias B. Moor, Balázs Győrffy, David Barras, Mauro Delorenzi, Konrad Basler, Michel Aguet
Publikováno v:
EBioMedicine, Vol 2, Iss 12, Pp 1932-1943 (2015)
BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a
Externí odkaz:
https://doaj.org/article/5d9510d1efc34bd0921ecd2bd9e0e19e
Autor:
Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T.M. Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S. Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S. Carroll, Wilbert Zwart, R. Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We
Externí odkaz:
https://doaj.org/article/0888c564b94245ac837fe1a7d55a9dc2
Autor:
Francisco J. Cimas, Arancha Manzano, Mariona Baliu-Piqué, Elena García-Gil, Pedro Pérez-Segura, Ádám Nagy, Atanasio Pandiella, Balázs Győrffy, Alberto Ocana
Publikováno v:
Cancers, Vol 12, Iss 8, p 2243 (2020)
Treatment with anti-PD-L1 antibodies has shown efficacy in basal-like breast cancer. In this context, identification of pre-activated immune tumors is a main goal. Here we explore mutations in PD1 and PD-L1 high-expressing tumors to identify genomic
Externí odkaz:
https://doaj.org/article/764af2f6896c4db2a91fe2f84a29ea7a
Autor:
Giuseppina Augimeri, Giusi La Camera, Luca Gelsomino, Cinzia Giordano, Salvatore Panza, Diego Sisci, Catia Morelli, Balázs Győrffy, Daniela Bonofiglio, Sebastiano Andò, Ines Barone, Stefania Catalano
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5841 (2020)
Aromatase inhibitors (AIs) represent the standard anti-hormonal therapy for post-menopausal estrogen receptor-positive breast cancer, but their efficacy is limited by the emergence of AI resistance (AIR). Exosomes act as vehicles to engender cancer p
Externí odkaz:
https://doaj.org/article/d14a05af4b9142a88121238107e8fbfb
Autor:
Lei Zhu, Barbara Hissa, Balázs Győrffy, Johann-Christoph Jann, Cui Yang, Christoph Reissfelder, Sebastian Schölch
Publikováno v:
Diagnostics, Vol 10, Iss 5, p 305 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most frequent cause of death from cancer. Circulating tumor cells (CTCs) with stem-like characteristics lead to distant metastases and thus contribute to the dismal prognosis of PDAC. Our purpose
Externí odkaz:
https://doaj.org/article/5dd1bec6cb9c4fdc856d07e05d9b62c7
Autor:
Áron Bartha, Balázs Győrffy
Publikováno v:
Cancers, Vol 11, Iss 11, p 1725 (2019)
Whole exome sequencing (WES) enables the analysis of all protein coding sequences in the human genome. This technology enables the investigation of cancer-related genetic aberrations that are predominantly located in the exonic regions. WES delivers
Externí odkaz:
https://doaj.org/article/cd6fcb95b1e946c69f731f7799cdf6a2
Autor:
Stefania Catalano, Salvatore Panza, Giuseppina Augimeri, Cinzia Giordano, Rocco Malivindi, Luca Gelsomino, Stefania Marsico, Francesca Giordano, Balázs Győrffy, Daniela Bonofiglio, Sebastiano Andò, Ines Barone
Publikováno v:
Cancers, Vol 11, Iss 11, p 1740 (2019)
The overexpression of phosphodiesterase (PDE) 5 is frequently found in various human cancers, such as those of the breast. However, PDE5’s role in the tumor microenvironment is still unknown. As PDE5 represents a high-value therapeutic target, we i
Externí odkaz:
https://doaj.org/article/ba2e638302e149e5bc2fac711196da2b