Zobrazeno 51 - 60
of 306
pro vyhledávání: '"Atul K. Bhan"'
Autor:
Atsuhiro Ogawa, Atsushi Mizoguchi, Shiv Pillai, Yasuyo Shimomura, Ken Sugimoto, Hai Ning Shi, Mayumi Kawada, Emiko Mizoguchi, Atul K. Bhan
Publikováno v:
Journal of Experimental Medicine. 205:1343-1355
Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM+ B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We describe a
Autor:
Hiroshi Chinen, Tomoaki Naito, Kouji Matsushima, Hideo Yamagishi, Yasuyo Shimomura, Tadakazu Hisamatsu, Makoto Suematsu, Ken Sugimoto, Nagamu Inoue, Atsushi Mizoguchi, Masanobu Nanno, Atul K. Bhan, Tetsuo Shiohara, Hiromichi Ishikawa, Yasuyoshi Kanari, Satoshi Ueha, Toshifumi Hibi
Publikováno v:
Gastroenterology. 134:481-490
Background & Aims: T-cell receptor (TCR) γδ T cells are an important component of the mucosal immune system and regulate intestinal epithelial homeostasis. Interestingly, there is a significant increase in γδ T cells in the inflamed mucosa of pat
Publikováno v:
Cancer. 109:2490-2496
Chronic hepatitis C can result in fatty changes in the liver. Previous studies have suggested that hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus (HCV) infection. The authors sought to determine whe
Autor:
Yasuyo Shimomura, Kiyotaka Nagahama, Atsushi Mizoguchi, Emiko Mizoguchi, Atsushiro Ogawa, Richard S. Blumberg, Ken Sugimoto, Atul K. Bhan, Takashi Nagaishi, Katsunori Shirane, Hidetoshi Takedatsu
Publikováno v:
Journal of Clinical Investigation. 117:605-615
Granulomas represent a localized inflammatory reaction that is characteristically observed in many inflammatory conditions. However, the mechanisms of granuloma formation have not been fully defined. Herein we demonstrate, by using experimental model
Autor:
Vinicius Cotta-de-Almeida, Fuminao Takeshima, Scott B. Snapper, Atul K. Bhan, Pierre Michetti, Michel H. Maillard, Deanna D. Nguyen, Cathryn R. Nagler
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 204, no. 2, pp. 381-91
Journal of Experimental Medicine, vol. 204, no. 2, pp. 381-91
The Wiskott-Aldrich syndrome, a primary human immunodeficiency, results from defective expression of the hematopoietic-specific cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASP). Because CD4+CD25+Foxp3+ naturally occurring regulatory T (
Autor:
Shannon K. Bromley, Atul K. Bhan, Terry K. Means, Andrew D. Luster, Fumitaka Hayashi, Krister J. Jones, Qian Yuan
Publikováno v:
The Journal of Experimental Medicine
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the intestine. CD4+ T lymphocytes play an important role in both initiating and regulating intestinal inflammatory immune responses. CD4+CD25+CD45RBlow regulatory T (T reg) cel
Autor:
S. Hakimian, Rizwan Ahmed, Mussa M. Rafat Mohamed, Kanakaraju Kaliannan, Palak Patel, Omeed Moaven, Caleb D. Phillips, Konstantinos P. Economopoulos, Sayeda Nasrin Alam, Naomi L. Ward, Madhu S. Malo, J. F. Haller, Abeba Teshager, Stephen B. Cox, Richard A. Hodin, Atul K. Bhan, Allan M. Goldstein
Publikováno v:
Diabetes, obesitymetabolism. 18(5)
Aims To examine whether co-administration of intestinal alkaline phosphatase (IAP) with antibiotics early in life may have a preventive role against metabolic syndrome (MetS) in mice. Methods A total of 50 mice were allocated to four treatment groups
Publikováno v:
International journal of obesity (2005). 40(6)
Early-life antibiotic exposure can disrupt the founding intestinal microbial community and lead to obesity later in life. Recent studies show that omega-3 fatty acids can reduce body weight gain and chronic inflammation through modulation of the gut
Autor:
Erica Magelky, Michael Thiele, Manfred Rieger, Hartmut J. Ehrlich, Frederick W.K. Tam, Mei-Ching Yu, John P. McDaid, Bernd Jilma, Friedrich Scheiflinger, Cox Terhorst, Alexander R. Moschen, Alexander Schinagl, Geert C. Mudde, Herbert Tilg, Randolf Kerschbaumer, Jennifer Smith, Atul K. Bhan, H. Terence Cook, Charles D. Pusey, Patrice Douillard, Harald Kühnel, Josef Kovarik, Dirk Völkel, G. Bhangal
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different from other cytokines because it is constitutively expressed, stored in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c3d184f5938784d2b75f1a157050b
https://europepmc.org/articles/PMC4543907/
https://europepmc.org/articles/PMC4543907/
Autor:
Marly I. Roche, Melanie Schirmer, Gautam Goel, Atul K. Bhan, Alykhan F. Shamji, John J. O'Shea, David Dombkowski, Thomas B. Sundberg, Stuart L. Schreiber, John D. Gagnon, Bernard Khor, Alison M. Paterson, Arlene H. Sharpe, Benjamin D. Medoff, Khoa D. Tran, Scott Mordecai, Kara L. Conway, Nicholas P. Restifo, Ramnik J. Xavier, Stanley Y. Shaw, Leslie N Aldrich, Rahul Roychoudhuri, Pauline H. Tan
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua