Zobrazeno 61 - 70
of 677
pro vyhledávání: '"Asla Pitkänen"'
Autor:
Robert Ciszek, Natallie Kajevu, Xavier Ekolle Ndode-Ekane, Jenni Kyyriäinen, Shalini Das Gupta, Mette Heiskanen, Tomi Paananen, Asla Pitkänen, Leonardo Lara-Valderrábano, Niina Lapinlampi, Niina Vuokila, Pedro Andrade, Noora Puhakka, Ivette Bañuelos-Cabrera
Publikováno v:
Epilepsybehavior : EB. 121
A biomarker is a characteristic that can be objectively measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Quantification of plasma microRNAs (miRNAs) as non-invasive disease biomarkers is subject to multiple technical variabilities. This study aimed to develop an optimized protocol for miRNA quantification from rodent plasma. We hypothesized that a fixed
Autor:
Helen E. Scharfman, Asla Pitkänen, Vicky Whittemore, Lauren C. Harte-Hargrove, Aristea S. Galanopoulou, Jacqueline A. French
Publikováno v:
Epilepsia Open
Summary Common data elements (CDEs) are becoming more common as more areas of preclinical research have generated CDEs. Herein we provide an overview of the progress to date in generating CDEs for preclinical epilepsy research. Currently there are CD
Autor:
Aristea S. Galanopoulou, Lauren C. Harte-Hargrove, Vicky Whittemore, Jacqueline A. French, Helen E. Scharfman, Asla Pitkänen
Publikováno v:
Epilepsia Open
Autor:
Asla Pitkänen, Leonardo Lara-Valderrábano, Jenni Karttunen, Xavier Ekolle Ndode-Ekane, Mehwish Anwer, Noora Puhakka
Publikováno v:
Journal of neurotrauma. 37(7)
Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophy
Autor:
Gregory Smith, Idrish Ali, Richard J. Staba, César Emmanuel Santana-Gómez, Rhys D. Brady, Emma L. Braine, Tomi Paananen, Pedro Andrade, Riikka Immonen, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Matthew R. Hudson, Jussi Tohka, Pablo M. Casillas-Espinosa, Terence J. O'Brien, Sandy R. Shultz, Robert Ciszek, Nigel C. Jones, Asla Pitkänen, Piero Perucca
Publikováno v:
Epilepsy Res
Rationale The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded multicenter consortium. One of EpiBioS4Rx projects is a preclinical post-traumatic epileptogenesis biomarker study that invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f31fe9664ccc8ded3340863076b0b59
https://escholarship.org/uc/item/2w8178fh
https://escholarship.org/uc/item/2w8178fh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Progress in the preclinical and clinical development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI) necessitates the discovery of prognostic biomarkers for post-injury outcome. Our previous mRNA-seq data revealed
Autor:
Aristea S. Galanopoulou, Lauren C. Harte-Hargrove, Helen E. Scharfman, Vicky Whittemore, Asla Pitkänen, Jacqueline A. French
Publikováno v:
Epilepsia. 58:78-86
The major objective of preclinical translational epilepsy research is to advance laboratory findings toward clinical application by testing potential treatments in animal models of seizures and epilepsy. Recently there has been a focus on the failure
Publikováno v:
Journal of Neurotrauma. 34:1482-1487
Sleep disturbances commonly occur after traumatic brain injury (TBI) and may predispose patients to epileptic seizures. We hypothesized that unprovoked seizure occurrence post-TBI depends on the sleep-wake cycle, and that the electrographic character
Autor:
Anu Lipsanen, Wolfgang Löscher, Olli Gröhn, Albert J. Becker, Teresa Ravizza, Michele Simonato, Niina Lapinlampi, Jan A. Gorter, Merab Kokaia, Jussi Paananen, Asla Pitkänen, Cristophe Bernard, Eleonora Aronica, Jens P. Bankstahl, Esbjörn Melin, Annamaria Vezzani, Paolo Roncon, Katarzyna Lukasiuk
Publikováno v:
Epilepsy Research, 129, 87-90. Elsevier
Epilepsy Research
Epilepsy Research, Elsevier, 2017, 129, pp.87-90. ⟨10.1016/j.eplepsyres.2016.11.010⟩
Epilepsy research, 129, 87-90. Elsevier
Epilepsy Research
Epilepsy Research, Elsevier, 2017, 129, pp.87-90. ⟨10.1016/j.eplepsyres.2016.11.010⟩
Epilepsy research, 129, 87-90. Elsevier
Article
Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data col
Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data col