Zobrazeno 91 - 100
of 677
pro vyhledávání: '"Asla Pitkänen"'
Autor:
Stephan, Missault, Lore, Peeters, Halima, Amhaoul, David, Thomae, Annemie, Van Eetveldt, Barbara, Favier, Anagha, Thakur, Jeroen, Van Soom, Asla, Pitkänen, Koen, Augustyns, Jurgen, Joossens, Steven, Staelens, Stefanie, Dedeurwaerdere
Publikováno v:
Epilepsia. 58(9)
Urokinase-type plasminogen activator (uPA) and kallikrein-related peptidase 8 (KLK8) are serine proteases that contribute to extracellular matrix (ECM) remodeling after brain injury. They can be labelled with the novel radiotracer [In the KASE model,
Autor:
Avtar Roopra, Claude G. Wasterlain, Michael A. Rogawski, Wytse J. Wadman, Douglas A. Coulter, Nadia Lelutiu, Pate Skene, Brita Fritsch, J. Victor Nadler, Yu Wang, Jan A. Gorter, James O. McNamara, Raymond Dingledine, Robert S. Sloviter, Asla Pitkänen
Publikováno v:
Scientific data, vol 4, iss 1
Scientific Data, 4:170061. Nature Publishing Group
Scientific Data, 4:170061. Nature Publishing Group
Global expression profiling of neurologic or psychiatric disorders has been confounded by variability among laboratories, animal models, tissues sampled, and experimental platforms, with the result being that few genes demonstrate consistent expressi
Autor:
Paolo Roncon, Jan A. Gorter, Eleonora Aronica, Asla Pitkänen, Marvin Johnson, Enrico Petretto, Prashant K. Srivastava, Michele Simonato, Katarzyna Lukasiuk
Publikováno v:
eNeuro
eNeuro, 4(6):e0152. Society for Neuroscience
eNeuro, 4(6):e0152-17.2017. Society for Neuroscience
eNeuro, 4(6):e0152. Society for Neuroscience
eNeuro, 4(6):e0152-17.2017. Society for Neuroscience
The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis.
Autor:
Tarja Malm, Asla Pitkänen, Mikko Hiltunen, Teemu Natunen, Joana I. Soares, Xavier Ekolle Ndode-Ekane, Pedro Andrade, Jukka Sallinen, Jari Nissinen, Katja M. Kanninen, Olena Shatillo
Publikováno v:
Epilepsy research. 136
Treatment of TBI remains a major unmet medical need, with 2.5 million new cases of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single-center proof-of-concept preclinical study tested the hypothesis that pharmacol
According to the World Health Organization, 50 million people worldwide have epilepsy. Traumatic brain injury (TBI) is estimated to cause 10%–20% of all of symptomatic epilepsies, and 5% of all epilepsies. Over the past 15 years, several laboratori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57d2580e0ab809bcb63b98ae044def7c
https://doi.org/10.1016/b978-0-12-804066-9.00046-8
https://doi.org/10.1016/b978-0-12-804066-9.00046-8
Autor:
Anagha Thakur, Barbara Favier, Stefanie Dedeurwaerdere, Koen Augustyns, Jeroen Van Soom, Annemie Van Eetveldt, Lore M. Peeters, Jurgen Joossens, Stephan Missault, Halima Amhaoul, Asla Pitkänen, Steven Staelens, David Thomae
Publikováno v:
Epilepsia
Objective: Urokinase-type plasminogen activator (uPA) and kallikrein-related peptidase 8 (KLK8) are serine proteases that contribute to extracellular matrix (ECM) remodeling after brain injury. They can be labelled with the novel radiotracer [In-111]
The main purpose of creating or identifying animal models for human seizures and epilepsies, as well as their associated pathologies and comorbidities, is to utilize them to elucidate the mechanisms underlying pathogenesis, and develop treatments tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ea624939e71ac81b10c4faa3a9fb09
https://doi.org/10.1016/b978-0-12-804066-9.00077-8
https://doi.org/10.1016/b978-0-12-804066-9.00077-8
Autor:
Asla Pitkänen, Heikki Tanila
Alzheimer’s disease (AD), especially its rare familial forms, is associated with increased risk of epilepsy. Research during the past decade has revealed that the most important genetic mouse model of AD, mice expressing mutated human amyloid precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36ecb09a330472ee4c77a53affb456f3
https://doi.org/10.1016/b978-0-12-804066-9.00071-7
https://doi.org/10.1016/b978-0-12-804066-9.00071-7
Autor:
Anna Maria Bot, Niina Vuokila, Noora Puhakka, Katarzyna Lukasiuk, Konrad J. Dębski, Asla Pitkänen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172521 (2017)
PLoS ONE
PLoS ONE
Traumatic brain injury (TBI) can result in several dentate gyrus-regulated disabilities. Almost nothing is known about the chronic molecular changes after TBI, and their potential as treatment targets. We hypothesized that chronic transcriptional alt