Zobrazeno 91 - 100
of 174
pro vyhledávání: '"Ansuman T. Satpathy"'
Autor:
Yanyan Qi, Daniel Nachun, Ansuman T. Satpathy, Paul K. Crane, Myriam Fornage, Sudha Seshadri, Julia A. Belk, Oscar L. Lopez, Siddhartha Jaiswal, Claudia L. Satizabal, Joshua C. Bis, Joshua S. Weinstock, Alexa S. Beiser, Winnie Yao, Matthew Chrostek, Chloé Sarnowski, Pradeep Nataranjan, W. T. Longstreth, Sara Wirth, Eric B. Larson, Hind Bouzid, Max Jan, Bruce M. Psaty, Herra Ahmad, Thomas J. Montine, C. Dirk Keene, Alexander G. Bick, Lisa Ma
Publikováno v:
Blood. 138:5-5
Clonal hematopoiesis of indeterminate potential (CHIP) occurs when hematopoietic stem cells (HSCs) acquire a mutation, most commonly a null variant in TET2 or DNMT3A, that confers a selective advantage. Blood cancers may result if additional cooperat
Publikováno v:
Science. 372:130-131
T cell dynamics reveal that immunotherapy responses may rely on peripheral T cells
Autor:
Howard Y. Chang, Fan Yang, Javaria Najeeb, Bryan A. Stevens, Ansuman T. Satpathy, Scott D. Boyd, Arjun Rustagi, Theodore S. Jardetzky, Katherine Jl Jackson, Catherine A. Blish, Ana R. Otrelo-Cardoso, Benjamin A. Pinsky, Peter S. Kim, Abigail E. Powell, Taia T. Wang, Angela J. Rogers, Kathryn E. Yost, Sandra C. A. Nielsen, Ji-Yeun Lee, Ramona A. Hoh, Katharina Röltgen, Bence Daniel
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
SUMMARYDuring virus infection B cells are critical for the production of antibodies and protective immunity. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d50bd2c3584152ad4606086aee98e01
https://doi.org/10.1101/2020.07.08.194456
https://doi.org/10.1101/2020.07.08.194456
Autor:
Matthew A, Nix, Kamal, Mandal, Huimin, Geng, Neha, Paranjape, Yu-Hsiu T, Lin, Jose M, Rivera, Makeba, Marcoulis, Kristie L, White, Jeffrey D, Whitman, Sagar P, Bapat, Kevin R, Parker, Jonathan, Ramirez, Anne, Deucher, Paul, Phojanokong, Veronica, Steri, Faranak, Fattahi, Byron C, Hann, Ansuman T, Satpathy, Aashish, Manglik, Elliot, Stieglitz, Arun P, Wiita
Publikováno v:
Cancer Discov
Alternate strategies are needed for B-cell malignancy patients relapsing after CD19-targeted immunotherapy. Here, cell surface proteomics revealed CD72 as an optimal target for poor-prognosis KMT2A/MLL1-rearranged (MLLr) B-ALL, which we further found
Autor:
Bence Daniel, Yu Xia, Takeshi Egawa, Ansuman T. Satpathy, Saravanan Raju, Elliot Bradshaw, Daniel Verbaro, Kathryn E. Yost, Elena Tonc
Persistent antigen induces a dysfunctional CD8 T cell state known as T cell “exhaustion” characterized by expression of PD-1 and decreased effector functions. Nevertheless, dysfunctional CD8 T cells can mediate control of antigen burden which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719b36fba927aeda1d311c951c6d6b34
Autor:
Howard Y. Chang, Peng Xu, Kevin R. Parker, Thomas J. Wandless, Zinaida Good, Elena Sotillo, Hima Anbunathan, Yanyan Qi, Robbie G. Majzner, Panayiotis Vandris, Ansuman T. Satpathy, Ling-chun Chen, Rachel C. Lynn, Crystal L. Mackall, Evan W. Weber, Andrew J. Gentles, Meena Malipatlolla, John Lattin
SUMMARYT cell exhaustion limits immune responses against cancer and is a major cause of resistance to CAR-T cell therapeutics. Using a model wherein tonic CAR signaling induces hallmark features of exhaustion, we employed a drug-regulatable CAR to te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0cb492f502fad83e1351f817e8403
https://doi.org/10.1101/2020.01.26.920496
https://doi.org/10.1101/2020.01.26.920496
Autor:
Bruce L. Levine, Vanessa E. Gonzalez, Simon F. Lacey, Wei-Ting Hwang, In-Young Jung, Yangbing Zhao, Lifeng Tian, Andrew D. Fesnak, Anne Lamontagne, Howard Y. Chang, Joanne Shea, Avery L. Gaymon, Patricia A. Mangan, Yanyan Qi, Adam D. Cohen, Elizabeth O. Hexner, Minnal Gupta, Edward A. Stadtmauer, Jun Xu, Joseph A. Fraietta, Amanda Cervini, Don L. Siegel, Anne Chew, Irina Kulikovskaya, Kevin R. Parker, Beatriz M. Carreno, Kristy L. Weber, Christopher L. Nobles, J. Joseph Melenhorst, Gabriela Plesa, Fang Chen, January Salas-Mckee, Eric Lancaster, Frederic D. Bushman, Carl H. June, Megan M. Davis, Ansuman T. Satpathy, Stephanie Desjardins, Regina M. Young, Tina Matlawski, Julie K. Jadlowsky
Publikováno v:
Int J Radiat Oncol Biol Phys
CRISPR takes first steps in humans CRISPR-Cas9 is a revolutionary gene-editing technology that offers the potential to treat diseases such as cancer, but the effects of CRISPR in patients are currently unknown. Stadtmauer et al. report a phase 1 clin
Autor:
Zinaida Good, Crystal L. Mackall, Dorota Klysz, Yanyan Qi, John Lattin, Louai Labanieh, Katalin Sandor, Bence Daniel, Howard Y. Chang, Peng Xu, Ansuman T. Satpathy, Thomas J. Wandless, Panayiotis Vandris, Elena Sotillo, Meena Malipatlolla, Ling-chun Chen, Andrew J. Gentles, Rachel C. Lynn, Sabine Heitzeneder, Hima Anbunathan, Evan W. Weber, Kevin R. Parker, Malek Bashti, Snehit Prabhu, Robbie G. Majzner, Julia A. Belk
Publikováno v:
Science (New York, N.Y.)
CAR-T cells rest to get back in the race Chimeric antigen receptor (CAR)–T cells, which are engineered to target specific tumor antigens, are increasingly used as an immunotherapy. CAR-T cells have shown promising results in patients, particularly
Autor:
Wing Hung Wong, Xi Chen, Howard Y. Chang, Mahdi Zamanighomi, Wanwen Zeng, Zhana Duren, Ansuman T. Satpathy, Yong Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Biological samples are often heterogeneous mixtures of different types of cells. Suppose we have two single-cell datasets, each providing information on a different cellular feature and generated on a different sample from this mixture.
Autor:
Richard Brotherton, A. Dimitrios Colevas, Kerri E. Rieger, Mark Y. Jeng, Roma Patel, Shufeng Li, Ansuman T. Satpathy, John G.D. Cannon, Duy C. Tran, Kavita Y. Sarin, Anne Lynn S. Chang, Lindsay Van der Bokke, Kathryn E. Yost, Sunil Reddy, Alana Pague
Publikováno v:
Journal of the American Academy of Dermatology