Zobrazeno 11 - 20
of 29
pro vyhledávání: '"Anssi Lipponen"'
Autor:
Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5395 (2019)
We developed a pipeline for the discovery of transcriptomics-derived disease-modifying therapies and used it to validate treatments in vitro and in vivo that could be repurposed for TBI treatment. Desmethylclomipramine, ionomycin, sirolimus and trimi
Externí odkaz:
https://doaj.org/article/f6399f138e4643869ce0fdf7641b06bc
Autor:
Asla Pitkänen, Noora Huusko, Xavier Ekolle Ndode-Ekane, Jenni Kyyriäinen, Anssi Lipponen, Anu Lipsanen, Alejandra Sierra, Tamuna Bolkvadze
Publikováno v:
Neurobiology of Disease, Vol 72, Iss , Pp 224-232 (2014)
Disease modification of epilepsy refers to the alleviation of epileptogenesis or comorbidities after genetic or acquired epileptogenic brain insults. There are currently 30 proof-of-concept experimental pharmacologic studies that have demonstrated so
Externí odkaz:
https://doaj.org/article/8f4ecbfa7d1043cf95c4ee94b3bed39a
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1259 (2019)
Extracellular vesicles (EVs) are small vesicles involved in intercellular communication. Data is emerging that EVs and their cargo have potential as diagnostic biomarkers and treatments for brain diseases, including traumatic brain injury and epileps
Externí odkaz:
https://doaj.org/article/2e94047ccb86483791a22e745fdf710b
Autor:
Noora Puhakka, Asla Pitkänen, Johanna Hiltunen, Anssi Lipponen, Günther Sperk, Xavier Ekolle Ndode-Ekane, Meinrad Drexel
Publikováno v:
Neuroscience. 475:52-72
Traumatic brain injury (TBI) causes 10–20% of structural epilepsy, with seizures typically originating in the cortex. Alterations in the neuronal microcircuits in the cortical epileptogenic zone, however, are poorly understood. Here, we assessed TB
Autor:
Ilkka T. Miettinen, Aapo Juutinen, Carita Savolainen-Kopra, Anniina Sarekoski, Anna-Maria Hokajarvi, Annastiina Rytkonen, Tarja Pitkänen, Pamela Österlund, Haider Al-Hello, Ananda Tiwari, Anssi Lipponen, Oskari Luomala
Wastewater-based surveillance is a cost-effective concept for monitoring COVID-19 pandemics at a population level. Here, SARS-CoV-2 RNA was monitored from a total of 693 wastewater (WW) influent samples from 28 wastewater treatment plants (WWTP, N =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::111bc7e13b89d50a2e8c066855ad830e
https://doi.org/10.1101/2021.10.05.21264462
https://doi.org/10.1101/2021.10.05.21264462
Autor:
Xavier Ekolle Ndode-Ekane, Heikki Tanila, Anssi Lipponen, Laura Oliva Pérez, Jenni Kyyriäinen, Asla Pitkänen, Hennariikka Koivisto, Tamuna Bolkvadze
Publikováno v:
Epilepsy Research. 151:67-74
Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the cerebral cortex and tissue remodeling after epileptogenic brain i
Autor:
Ananda Tiwari, Anssi Lipponen, Anna-Maria Hokajärvi, Oskari Luomala, Anniina Sarekoski, Annastiina Rytkönen, Pamela Österlund, Haider Al-Hello, Aapo Juutinen, Ilkka T. Miettinen, Carita Savolainen-Kopra, Tarja Pitkänen
Publikováno v:
Water Research. 215:118220
Wastewater-based surveillance is a cost-effective concept for monitoring COVID-19 pandemics at a population level. Here, SARS-CoV-2 RNA was monitored from a total of 693 wastewater (WW) influent samples from 28 wastewater treatment plants (WWTP, N =
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Progress in the preclinical and clinical development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI) necessitates the discovery of prognostic biomarkers for post-injury outcome. Our previous mRNA-seq data revealed
Publikováno v:
Microbial Ecology. 72:955-964
Environmentally transmitted opportunistic pathogens shuttle between two substantially different environments: outside-host and within-host habitats. These environments differ from each other especially with respect to nutrient availability. Consequen
Publikováno v:
Neuroscience Letters. 729:134935
Binding of urokinase-type plasminogen activator receptor (uPAR) to its ligand uPA or to its plasma membrane partner, platelet-derived growth factor receptor β (PDGFRβ), promotes neuroprotection, cell proliferation, and angiogenesis. Following injur