Zobrazeno 11 - 20
of 600
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Anthony E. Peters, Ambarish Pandey, Colby Ayers, Kara Wegermann, Robert W. McGarrah, Justin L. Grodin, Manal F. Abdelmalek, Tarek Bekfani, Vanessa Blumer, Anna Mae Diehl, Cynthia A. Moylan, Marat Fudim
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 842-848 (2021)
Abstract Aims Non‐alcoholic fatty liver disease leads to progressive liver fibrosis and appears to be a frequent co‐morbid disease in heart failure with preserved ejection fraction (HFpEF). It is well known that liver fibrosis severity predicts f
Externí odkaz:
https://doaj.org/article/e67e539858ad4fc2b3ae455e47041b95
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
Autor:
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein‐Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison Ashley‐Koch, Ayako Suzuki
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 598-607 (2021)
The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to iden
Externí odkaz:
https://doaj.org/article/b7925e634c3749e48299369bbda597e9
Autor:
Kara Wegermann, Catherine Howe, Ricardo Henao, Ying Wang, Cynthia D. Guy, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Identifying patients at higher risk for poor outcomes from nonalcoholic fatty liver disease (NAFLD) remains challenging. Metabolomics, the comprehensive measurement of small molecules in biological samples, has the potential to reveal novel noninvasi
Externí odkaz:
https://doaj.org/article/8827ebe784e343ad945032872f158e20
Autor:
Tinsay A. Woreta, Mark L. Van Natta, Mariana Lazo, Arunkumar Krishnan, Brent A. Neuschwander-Tetri, Rohit Loomba, Anna Mae Diehl, Manal F. Abdelmalek, Naga Chalasani, Samer Gawrieh, Srinivasan Dasarathy, Raj Vuppalanchi, Mohammad S. Siddiqui, Kris V. Kowdley, Arthur McCullough, Norah A. Terrault, Cynthia Behling, David E. Kleiner, Mark Fishbein, Paula Hertel, Laura A. Wilson, Emily P. Mitchell, Laura A. Miriel, Jeanne M. Clark, James Tonascia, Arun J. Sanyal, for the NASH Clinical Research Network
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Background and aims Management of patients with NASH who are at elevated risk of progressing to complications of cirrhosis (at-risk NASH) would be enhanced by an accurate, noninvasive diagnostic test. The new FAST™ score, a combination of FibroScan
Externí odkaz:
https://doaj.org/article/3774c2ebe409441cbe22e53a5e30eba8
Autor:
Marat Fudim, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, Jeroen Molinger, Cynthia A. Moylan, Vishal N. Rao, Kara Wegermann, Ian J. Neeland, Ethan A. Halm, Sandeep R. Das, Ambarish Pandey
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Background Nonalcoholic fatty liver disease (NAFLD) and heart failure (HF) are increasing in prevalence. The independent association between NAFLD and downstream risk of HF and HF subtypes (HF with preserved ejection fraction and HF with reduced ejec
Externí odkaz:
https://doaj.org/article/0348b254322045d6b98f37ff6e5d05af
Autor:
Kuo Du, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, Susanna Naggie, Cynthia A. Moylan, Mustafa R. Bashir, Manal F. Abdelmalek, Anna Mae Diehl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Background & Aims: Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how cha
Externí odkaz:
https://doaj.org/article/2913df394d7c4f06abb93625a9bfe0c6
Autor:
George D. Dalton, Seh-Hoon Oh, Linda Tang, Stephanie Zhang, Amanda L. Brown, Venkateshwari Varadharajan, Camelia Baleanu-Gogonea, Valentin Gogonea, Preeti Pathak, J. Mark Brown, Anna Mae Diehl
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103089- (2021)
Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sens
Externí odkaz:
https://doaj.org/article/bb55d9b8b9d44c2c84e49520c90d1dcf
Autor:
Shikha S. Sundaram, Marzena Swiderska‐Syn, Ronald J. Sokol, Ann C. Halbower, Kelley E. Capocelli, Zhaoxing Pan, Kristen Robbins, Brian Graham, Anna Mae Diehl
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 883-893 (2019)
Chronic intermittent hypoxia and hedgehog (Hh) pathway dysregulation are associated with nonalcoholic fatty liver disease (NAFLD) progression. In this study, we determined the relationship between obstructive sleep apnea (OSA)/nocturnal hypoxia and H
Externí odkaz:
https://doaj.org/article/d1840ce736084002a5ee66b931118c9b
Autor:
Oliver Glass, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing‐Kin Syn, Cynthia A. Moylan, Robert Streilein, Russell Hall, Anna Mae Diehl, Manal F. Abdelmalek
Publikováno v:
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Externí odkaz:
https://doaj.org/article/15c5b601b1564633b905485bbd685159
Autor:
Sarah E. Kleinstein, Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, Cynthia A. Moylan
Publikováno v:
Hepatology Communications, Vol 2, Iss 9, Pp 1021-1029 (2018)
Abstract Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease with highly variable outcomes. Patients with simple steatosis typically experience a benign course, whereas those with more advanced liver injury, nonalcoholic steatohepatit
Externí odkaz:
https://doaj.org/article/2a83b6bb981c4ad98bdc25157f8217b4