Zobrazeno 101 - 110
of 600
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Jason Gibson, David S. Hsu, Jeongeun Hyun, Anna Mae Diehl, Simon G. Gregory, Richard T. Premont, Cynthia D. Guy, Mark L. Jewell, Kuo Du, Seh-Hoon Oh, Thomas J. Ribar
Publikováno v:
Am J Pathol
Fibrolamellar carcinoma (FLC) is characterized by in-frame fusion of DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1) with protein kinase cAMP-activated catalytic subunit α (PRKACA) and by dense desmoplasia. Surgery is the only effective tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7b8fb52946e0d6a93a78c380043659
https://europepmc.org/articles/PMC10069284/
https://europepmc.org/articles/PMC10069284/
Background and AimsLiver fibrosis develops in the context of excessive oxidative stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate cells (HSCs). Ferroptosis is a type of regulated cell death that can be caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef9c6e3dd3130b4a811e359e407a456
https://doi.org/10.1101/2019.12.23.886259
https://doi.org/10.1101/2019.12.23.886259
Autor:
Geoffrey I. Scott, Varun Chandrashekaran, Prakash S. Nagarkatti, Diana Kimono, Samir Raychoudhury, Mitzi Nagarkatti, Sutapa Sarkar, Anna Mae Diehl, Firas Alhasson, Ratanesh Seth, Saurabh Chatterjee, Muayad Albadrani, Diptadip Dattaroy
Publikováno v:
Redox Biology, Vol 17, Iss, Pp 1-15 (2018)
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E
Autor:
Jeongeun Hyun, Anna Mae Diehl, Matthew B Friedersdorf, Youngmi Jung, Seh-Hoon Oh, Jack D. Keene, Richard T. Premont, Ji Eun Kim, Sihyung Wang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 3, Pp 1215-1229 (2018)
Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, eff
Autor:
Manal F. Abdelmalek, Richard T. Premont, Jeongeun Hyun, Mustafa R. Bashir, Cynthia A. Moylan, Kuo Du, Satish K. Chitneni, Ricardo Henao, Ayako Suzuki, Ying Wang, Anna Mae Diehl, Susanna Naggie
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Background & Aims Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how chan
Autor:
Rohit, Loomba, Brent A, Neuschwander-Tetri, Arun, Sanyal, Naga, Chalasani, Anna Mae, Diehl, Norah, Terrault, Kris, Kowdley, Srinivasan, Dasarathy, David, Kleiner, Cynthia, Behling, Joel, Lavine, Mark, Van Natta, Michael, Middleton, James, Tonascia, Claude, Sirlin, Tanya, Wolfson
Publikováno v:
Hepatology
BACKGROUND AND AIMS Emerging data from a single-center study suggests that a 30% relative reduction in liver fat content as assessed by magnetic resonance imaging-proton density fat fraction (MRI-PDFF) from baseline may be associated with histologic
Autor:
Elizabeth M. Brunt, Ryan M. Gill, Norah A. Terrault, Patricia Belt, Anna Mae Diehl, Brent A. Neuschwander-Tetri, Srinivasan Dasarathy, Oscar W. Cummings, Matthew M. Yeh, Cynthia Behling, Kris V. Kowdley, Cynthia D. Guy, Arun J. Sanyal, James Tonascia, Laura Wilson, David E. Kleiner, Melissa J. Contos, Rohit Loomba, Naga Chalasani, Joel E. Lavine
Publikováno v:
JAMA Network Open
Key Points Question In patients with nonalcoholic fatty liver disease who are not undergoing specific therapeutic interventions, what factors are associated with progression and regression of hepatic fibrosis? Findings In this cohort study of 446 pat
Autor:
Bryan W. Brooks, Mitzi Nagarkatti, Samir Raychoudhury, Anna Mae Diehl, Sutapa Sarkar, Dwayne E. Porter, Geoff Scott, Diana Kimono, Muayad Albadrani, Saurabh Chatterjee, Yvon Jule, Dipro Bose, Ratanesh Seth, Ayan Mondal, Prakash S. Nagarkatti
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Nonalcoholic fatty liver disease (NAFLD) is an emerging global pandemic. Though significant progress has been made in unraveling the pathophysiology of the disease, the role of protein phosphatase 2A (PP2A) and its subsequent inhibition by environmen
Autor:
Cynthia D. Guy, Claire Faulkner, Manal F. Abdelmalek, Larry Mimms, Ranjan Sudan, Anna Mae Diehl, Anjali Jain, Xiao-jun Li, Lauren Okada, Dana Portenier, S Singh, Lisa Richards, Rohit Loomba, Kelly D. Hester
Publikováno v:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol 17, iss 9
Background & Aims We analyzed markers of fibrosis in serum samples from patients with nonalcoholic fatty liver disease (NAFLD), assessed by liver biopsy. We used serum levels of markers to develop an algorithm to discriminate patients with advanced f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f3804628ef5863ad3bbb749e54907
https://escholarship.org/uc/item/0b04137v
https://escholarship.org/uc/item/0b04137v
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 53:264-278
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of obesity-associated liver diseases and it has become the major cause of cirrhosis in the Western world. The high prevalence of NAFLD-associated advanced liver disease reflects both the