Zobrazeno 41 - 50
of 385
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Joseph R. Testa, Frank J. Rauscher, Andres J. Klein-Szanto, Suraj Peri, Michael J. Slifker, Kathy Q. Cai, Yinfei Tan, Mitchell Cheung, Craig W. Menges, Yuwaraj Kadariya, Eleonora Sementino, Anna-Mariya Kukuyan
Assay IDs for quantitative RT-PCR analysis to validate genes differentially expressed between malignant mesotheliomas (MMs) derived from triple-CKO mice versus those from double-CKO mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d9decee3a9317212e5ec30f8058d9
https://doi.org/10.1158/0008-5472.22420944.v1
https://doi.org/10.1158/0008-5472.22420944.v1
Autor:
Joseph R. Testa, Frank J. Rauscher, Andres J. Klein-Szanto, Suraj Peri, Michael J. Slifker, Kathy Q. Cai, Yinfei Tan, Mitchell Cheung, Craig W. Menges, Yuwaraj Kadariya, Eleonora Sementino, Anna-Mariya Kukuyan
Characterization of malignant mesothelioma (MM) from Bap1f/f mouse, which was detected 45 weeks after intrathoracic injection of Adeno-Cre virus. A, Immunoblot confirming loss of Bap1 expression in MM from Bap1 conditional knockout mouse 526, with tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149c16ee0de35107e953c3e20081b198
https://doi.org/10.1158/0008-5472.22420956.v1
https://doi.org/10.1158/0008-5472.22420956.v1
Autor:
Anil K. Rustgi, Adam J. Bass, K.K. Wong, J. Alan Diehl, Arjun Raj, Margaret C. Dunagin, Qi Long, E. Paul Wileyto, David A. Frank, Sarah R. Walker, Zachary T. Giaccone, Kiichiro Baba, Shinya Ohashi, Devraj Basu, Varun Sahu, Andres J. Klein-Szanto, Monica Soni, Todd J. Waldron, Edmund Qiao, Qiaosi Tang, Eric W. Lin, Tatiana A. Karakasheva
Supplementary Materials and Methods with expanded description of cell lines, 2D co-culture of ESCC cells and CAFs, 3D tumoroid and organotypic cultures, xenograft tumors, generation of CRISPR knockout cell lines, real-time qPCR, histology and RNA in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4717d247043f0b25e59dde5d48d5ea50
https://doi.org/10.1158/0008-5472.22418912
https://doi.org/10.1158/0008-5472.22418912
Autor:
Joseph R. Testa, Frank J. Rauscher, Andres J. Klein-Szanto, Suraj Peri, Michael J. Slifker, Kathy Q. Cai, Yinfei Tan, Mitchell Cheung, Craig W. Menges, Yuwaraj Kadariya, Eleonora Sementino, Anna-Mariya Kukuyan
100 of the top gene sets differentially affected (FDR < 0.25) in MMs from triple-CKOa versus those from double-CKO mice by using GSEA applied to MSigDB gene sets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fca8f1499ac364e0f5ae24d7f6446
https://doi.org/10.1158/0008-5472.22420938.v1
https://doi.org/10.1158/0008-5472.22420938.v1
Autor:
Joseph R. Testa, Frank J. Rauscher, Andres J. Klein-Szanto, Suraj Peri, Michael J. Slifker, Kathy Q. Cai, Yinfei Tan, Mitchell Cheung, Craig W. Menges, Yuwaraj Kadariya, Eleonora Sementino, Anna-Mariya Kukuyan
Differences in survival of mice succumbing to malignant mesothelioma after IT injection with Adeno-Cre in different conditional knockout mouse groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa13d6fa1c6e30245a3c9ade10dbf895
https://doi.org/10.1158/0008-5472.22420941
https://doi.org/10.1158/0008-5472.22420941
Autor:
Joseph R. Testa, Rakesh Kumar, Andres J. Klein-Szanto, Antonio Di Cristofano, Jing Deng, Lili Zhang, Deborah A. Altomare
Purpose: Akt plays a central role in regulating tumor cell survival and cell cycle progression and is regarded as a promising therapeutic target. We used genetically defined mouse models that develop spontaneous tumors exhibiting activated Akt to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1b591919e515be20d19a5f56aa8332
https://doi.org/10.1158/1078-0432.c.6517873
https://doi.org/10.1158/1078-0432.c.6517873
Autor:
Anil K. Rustgi, Adam J. Bass, K.K. Wong, J. Alan Diehl, Arjun Raj, Margaret C. Dunagin, Qi Long, E. Paul Wileyto, David A. Frank, Sarah R. Walker, Zachary T. Giaccone, Kiichiro Baba, Shinya Ohashi, Devraj Basu, Varun Sahu, Andres J. Klein-Szanto, Monica Soni, Todd J. Waldron, Edmund Qiao, Qiaosi Tang, Eric W. Lin, Tatiana A. Karakasheva
Fig. S1 demonstrates that human CAFs survive within xenograft tumors Fig. S2 shows the results of quality control for CRISPR-mediated knockout cell lines Fig. S3 shows enhanced tumor growth is ESCC cells are co-implanted with CAF Fig. S4 shows data s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1444dbbd6fea207d84eb7b58363f22d7
https://doi.org/10.1158/0008-5472.22418915
https://doi.org/10.1158/0008-5472.22418915
Autor:
Anil K. Rustgi, Adam J. Bass, K.K. Wong, J. Alan Diehl, Arjun Raj, Margaret C. Dunagin, Qi Long, E. Paul Wileyto, David A. Frank, Sarah R. Walker, Zachary T. Giaccone, Kiichiro Baba, Shinya Ohashi, Devraj Basu, Varun Sahu, Andres J. Klein-Szanto, Monica Soni, Todd J. Waldron, Edmund Qiao, Qiaosi Tang, Eric W. Lin, Tatiana A. Karakasheva
sequences for qPCR probes used in the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407013771a64b74c12de591249f7905
https://doi.org/10.1158/0008-5472.22418909.v1
https://doi.org/10.1158/0008-5472.22418909.v1
Autor:
Joseph R. Testa, Frank J. Rauscher, Andres J. Klein-Szanto, Suraj Peri, Michael J. Slifker, Kathy Q. Cai, Yinfei Tan, Mitchell Cheung, Craig W. Menges, Yuwaraj Kadariya, Eleonora Sementino, Anna-Mariya Kukuyan
RT-PCR analysis was performed on 13 of 16 PRC2 target genes indicated in the heatmap derived from the RNA-seq analysis of genes differentially expressed between malignant mesotheliomas (MMs) from Nf2;Cdkn2a double-CKO mice and Bap1;Nf2;Cdkn2a triple-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00caf59b56c414ecba035813d959f0fc
https://doi.org/10.1158/0008-5472.22420950
https://doi.org/10.1158/0008-5472.22420950
Autor:
Anil K. Rustgi, Adam J. Bass, K.K. Wong, J. Alan Diehl, Arjun Raj, Margaret C. Dunagin, Qi Long, E. Paul Wileyto, David A. Frank, Sarah R. Walker, Zachary T. Giaccone, Kiichiro Baba, Shinya Ohashi, Devraj Basu, Varun Sahu, Andres J. Klein-Szanto, Monica Soni, Todd J. Waldron, Edmund Qiao, Qiaosi Tang, Eric W. Lin, Tatiana A. Karakasheva
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::187cf4ae24561e7e8e2fcd05985d3618
https://doi.org/10.1158/0008-5472.c.6510254.v1
https://doi.org/10.1158/0008-5472.c.6510254.v1