Zobrazeno 241 - 250
of 385
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Jenna Travis, Jonathan P. Katz, Qian-Chun Yu, Andres J. Klein-Szanto, Marie Pier Tetreault, Yizeng Yang, Mei-Lun Wang
Background & Aims Esophageal squamous cell cancer accounts for more than 90% of cases of esophageal cancers. Its pathogenesis involves chronic epithelial irritation, although the factors involved in the inflammatory process and the mechanisms of carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b047c7bebf1ba7bf18ebe371e29116
https://europepmc.org/articles/PMC3457785/
https://europepmc.org/articles/PMC3457785/
Autor:
Laura E. Bickel, Xiang Hua, Denise C. Connolly, Lainie P. Martin, Fang Xiao, Bridget A. Quinn, Andres J. Klein-Szanto
Publikováno v:
Journal of Ovarian Research, Vol 3, Iss 1, p 24 (2010)
Journal of Ovarian Research
Journal of Ovarian Research
Background Most cases of ovarian cancer are epithelial in origin and diagnosed at advanced stage when the cancer is widely disseminated in the peritoneal cavity. The objective of this study was to establish an immunocompetent syngeneic mouse model of
Autor:
Eugene Izumchenko, Andres J. Klein-Szanto, Mahendra K. Singh, Marina Wolfson, Erica A. Golemis, Brian L. Egleston
Publikováno v:
Cancer research. 70(21)
Elevated expression of the NEDD9/HEF1/Cas-L scaffolding protein promotes tumor cell invasion and metastasis in multiple cancer cell types. Conversely, generation of mammary tumors in the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyVT)
Autor:
Gabrielle S. Wong, Mitsuteru Natsuizaka, Meenhard Herlyn, J. Alan Diehl, Hiroshi Nakagawa, Shinya Ohashi, Andres J. Klein-Szanto, Daniela Budo, Ross A. Kalman, Azal Ahmadi
Publikováno v:
Carcinogenesis. 31(8)
Insulin-like growth factor-binding protein (IGFBP)-3 is overexpressed frequently in esophageal squamous cell carcinoma. Yet, the role of IGFBP3 in esophageal tumor biology remains to be elucidated. We find that IGFBP3 facilitates transforming growth
Autor:
Andres J. Klein-Szanto, Carmen Z. Michaylira, Yao Yao, Anil K. Rustgi, Shinya Ohashi, Charles G. Miller, J. Alan Diehl, Hiroshi Nakagawa, Katharine D. Grugan, Meenhard Herlyn, May Han
Squamous cell cancers comprise the most common type of human epithelial cancers. One subtype, esophageal squamous cell carcinoma (ESCC), is an aggressive cancer with poor prognosis due to late diagnosis and metastasis. Factors derived from the extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca594d0ad6693d102f52803ca2c8ee1
https://europepmc.org/articles/PMC2890722/
https://europepmc.org/articles/PMC2890722/
Autor:
Kathryn Fong, Ricardo Lopez de Cicco, Daniel E. Bassi, Andres J. Klein-Szanto, Fernando Benavides, Jirong Zhang, Fang Jin, Karl-Heinz Braunewell, Claudio J. Conti, Jian Fu, Divya Ramaraju
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10196 (2010)
PLoS ONE
PLoS ONE
VILIP-1, a member of the neuronal Ca(2+) sensor protein family, is able to act as a tumor suppressor in carcinoma cells by inhibiting cell proliferation and migration. In order to study the role of VILIP-1 in skin carcinogenesis we generated transgen
Autor:
Tianyu Li, Fang Zhu, V. Craig Jordan, Eric A. Ross, Andres J. Klein-Szanto, Jennifer R. Pyle, Roshani R. Patel, Joseph Fargnoli, Helen R. Kim, Salewa Oseni, Surojeet Sengupta
Purpose Tamoxifen, a selective oestrogen receptor modulator (SERM), and brivanib alaninate, a vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, are two target specific agents that result in a substantial decrease in tumour growth whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bd7c726fc2b063fb24897f02793b6a
https://europepmc.org/articles/PMC2927957/
https://europepmc.org/articles/PMC2927957/
Autor:
Andres J. Klein-Szanto, Lili Zhang, Rakesh Kumar, Deborah A. Altomare, Antonio Di Cristofano, Joseph R. Testa, Jing Deng
Purpose: Akt plays a central role in regulating tumor cell survival and cell cycle progression and is regarded as a promising therapeutic target. We used genetically defined mouse models that develop spontaneous tumors exhibiting activated Akt to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f590cadc88b277f050bc83696e4cec6c
https://europepmc.org/articles/PMC2807995/
https://europepmc.org/articles/PMC2807995/
Autor:
Andres J. Klein-Szanto, Beatrice Mintz
Publikováno v:
Proceedings of the National Academy of Sciences. 89:11421-11425
Eye tumors of the retinal pigment epithelium (RPE) have been thought generally to be benign, whereas choroidal ones are malignant. To test this assumption in mice, the W/Wv (Kit) mutant genotype was introduced into melanoma-prone transgenic mice whos
Publikováno v:
International Journal of Cancer. 52:366-371
Numerous studies have reported a correlation between production of 72-kDa (MMP-2) and 92-kDa (MMP-9) type-IV collagenases/gelatinases and the metastatic potential of cancer cells. An abrogating effect of tissue inhibitors of metalloproteinases (TIMP-