Zobrazeno 31 - 40
of 312
pro vyhledávání: '"Alexander M. Klibanov"'
Autor:
Erzheng Su, Alexander M. Klibanov
Publikováno v:
Springer US
Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in
Publikováno v:
Biotechnology Progress. 22:584-589
Previously we found that covalent attachment of long-chained, moderately hydrophobic polycations to surfaces of solid objects renders the latter permanently bactericidal. Herein we replaced such surface-specific, multistep immobilization techniques w
Autor:
Alexander M. Klibanov, Ju-Hyun Yu
Publikováno v:
Biotechnology Letters. 28:555-558
The impact of co-lyophilizing horseradish peroxidase (HRP) with numerous amino acids and other chiral excipients on the enzyme's subsequent stereoselectivity [E(S/R)] in the sulfoxidation of thioanisole in 2-propanol was systematically investigated.
Publikováno v:
Biomacromolecules. 16(1)
A number of N-alkylated polyethylenimines (PEIs) were covalently attached to glass-slide surfaces, and their virucidal efficacies against three different strains of influenza viruses were examined quantitatively. The anti-influenza activities of the
Autor:
Kim Lewis, Alexander M. Klibanov
Publikováno v:
Trends in Biotechnology. 23:343-348
The rise of multidrug-resistant pathogens and recalcitrance of biofilm infections present a formidable challenge to combating infectious diseases. There are numerous disinfectants and antiseptics for treating materials in hospitals and community sett
Publikováno v:
Expert Opinion on Biological Therapy. 5:495-505
Influenza A virus causes one of the most prevalent infections in humans. In a typical year, 10-20% of the population of the US is infected by influenza virus, resulting in up to 40,000 deaths and 200,000 hospitalisations. Vaccination is the most effe
Autor:
Alexander M. Klibanov, Linda G. Griffith, Nathan C. Tedford, Csanad M. Varga, Douglas A. Lauffenburger, Mini Thomas
Publikováno v:
Gene Therapy. 12:1023-1032
An objective of designing molecular vehicles exhibiting virus-like transgene delivery capabilities but with low toxicity and immunogenicity continues to drive synthetic vector development. As no single step within the gene delivery pathway represents
Publikováno v:
Pharmaceutical Research
No Heading Purpose. Polyethylenimine (PEI) is among the most efficient nonviral gene delivery vectors. Its efficiency and cytotoxicity depend on molecular weight, with the 25-kDa PEI being most efficient but cytotoxic. Smaller PEIs are noncytotoxic b
Publikováno v:
The Journal of Gene Medicine. 7:657-663
Background The relatively high transfection efficiency of polyethylenimine (PEI) vectors has been hypothesized to be due to their ability to avoid trafficking to degradative lysosomes. According to the proton sponge hypothesis, the buffering capacity
Publikováno v:
Biotechnology and Bioengineering. 90:715-722
Several critical mechanistic and phenomenological aspects of the microbicidal surface coatings based on immobilized hydrophobic polycations, previously developed by us, are addressed. Using Escherichia coli (Gram-negative) and Staphylococcus aureus (