Zobrazeno 31 - 40
of 63
pro vyhledávání: '"Ajay Nirula"'
Autor:
Alice B. Gottlieb, James G. Krueger, Ajay Nirula, Gregory Kricorian, Darryl Toth, Andrew Blauvelt, Kim A. Papp, Joanne Li, Kristian Reich, Carle Paul, Diamant Thaçi, Cassandra E Milmont, Richard G. Langley, Chris B. Russell, Paul Klekotka, W. Baran, Chantal Bolduc, J. Cather
Publikováno v:
The British journal of dermatology. 175(2)
SummaryBackground The interleukin-17 cytokine family plays a central role in psoriasis pathogenesis. Objectives To evaluate the efficacy and safety of brodalumab, a human anti-interleukin-17 receptor antibody, in treating patients with moderate-to-se
Autor:
Ajay Nirula, Joanne Li, Carle Paul, Andrew Blauvelt, David J. Harrison, Lionel Pinto, Kenneth B. Gordon, Kristian Reich, Cassandra E Milmont, Greg Kricorian, Bruce Strober, Kim A. Papp, Mark Lebwohl, Hema N. Viswanathan, Paul Klekotka
Publikováno v:
Journal of the American Academy of Dermatology. 75(1)
New psoriasis therapies have increased the ability to achieve skin clearance. However, insufficient evidence exists on the impact of total skin clearance from the patient perspective.We sought to determine if complete skin clearance is clinically mea
Autor:
Hao Zhang, Hilary Wilson, Bruce Strober, Matthias Augustin, Gregory Kricorian, Hema N. Viswanathan, Kenneth B. Gordon, Ajay Nirula, Alex Mutebi, Cassandra E Milmont, Dennis A. Revicki, Paul Klekotka
Publikováno v:
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 20(8)
The Psoriasis Symptom Inventory (PSI) is a patient-reported outcome instrument that measures the severity of psoriasis signs and symptoms. This study evaluated measurement properties of the PSI in patients with moderate to severe plaque psoriasis.Thi
Autor:
Ajay Nirula, Edward P. Ingenito, Peter J. Sterk, Ian M. Adcock, Dirk E. Smith, Jeanette Bigler, Ratko Djukanovic, Anthony Rowe, Fan Chung, Ana R. Sousa
Publikováno v:
5.3 Allergy and Immunology.
Background: FEV1 correlates with symptoms and exacerbation risk in asthma. Although considered an index of airway resistance (R), FEV1 also varies with vital capacity (VC) as a function of airway recruitment. Aims: Quantify the contributions of airwa
Autor:
Fan Chung, Ajay Nirula, Edward P. Ingenito, Jeanette Bigler, Ratko Djukanovic, Peter J. Sterk, Ian M. Adcock, Dirk E. Smith, Ana E. Sousa, Anthony Rowe
Publikováno v:
5.3 Allergy and Immunology.
Autor:
Larissa Wenning, Eseng Lai, Allen N. Jones, George A. Doss, Eric Soli, Graigory Garrett, David J. Schenk, Maria Madeira, Bindhu V. Karanam, Rajesh Desai, Ajay Nirula, Scott Bradley, Tami Crumley, Brian Dean
Publikováno v:
Drug Metabolism and Disposition. 35:1196-1202
[(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopentaindol-3-yl]acetic acid (MK-0524) is a potent orally active human prostaglandin D(2) receptor 1 antagonist that is currently under development for the prevention of niaci
Autor:
J. Feng, Ajay Nirula, Edward P. Ingenito, Sally W. Wenzel, Stephen T. Holgate, Yun Chon, Paul Klekotka, William W. Busse
BACKGROUND High bronchodilator reversibility in adult asthma is associated with distinct clinical characteristics. This analysis compares lung function, biomarker profiles, and disease control in patients with high reversibility (HR) and low reversib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149fa75d158f7ec380ca8494c49174f5
https://europepmc.org/articles/PMC4665740/
https://europepmc.org/articles/PMC4665740/
Autor:
Alan Menter, Joanne Li, Alexa B. Kimball, Darryl Toth, April W. Armstrong, Wenjie Song, Gary Aras, Cassandra E Milmont, Lluís Puig, Brian L Kotzin, Jolanta Weglowska, Hervé Bachelez, John Koo, Ajay Nirula, Jean-Philippe Lacour, Leon H Kircik, Kristina Callis Duffin, Lynda Spelman, Francisco A. Kerdel, Mark Lebwohl, Tomasz Blicharski, Richard G. Langley, Bruce Strober, Stephen K. Tyring, Kim A. Papp, Jeffrey J. Crowley, Jashin J. Wu, Sergio Chimenti, Carle Paul, Kenneth B. Gordon, Yifei Shi, Paul Klekotka, Ngozi Erondu, Georg Stingl, Jerry Bagel
Publikováno v:
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis.In two phase 3 studies (AMAGINE-2 and AMAGINE-3), patients with moderate-to-severe psoriasis were rando
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47ddc2f5ccc53f4bb1b06d5b762e857
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8339
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8339
Publikováno v:
The Journal of Experimental Medicine
CD28 plays a critical role in T cell immune responses. Although the kinase Akt has been shown to act downstream of CD28 in T helper (Th)1 cytokine induction, it does not induce Th2 cytokines such as interleukin 4 (IL-4). We recently reported that pho
Autor:
Hilary D, Wilson, Alex, Mutebi, Dennis A, Revicki, Philip J, Mease, Mark C, Genovese, Ngozi, Erondu, Ajay, Nirula, Feng Jing, Yuan, Hema N, Viswanathan
Publikováno v:
Arthritis careresearch. 67(12)
To evaluate the measurement properties of the Psoriasis Symptom Inventory (PSI) in psoriatic arthritis (PsA).The PSI is an 8-item, patient-reported outcome measure of the severity of psoriasis signs and symptoms. This was a secondary analysis of pool