Zobrazeno 41 - 50
of 1 198
pro vyhledávání: '"Afd Pharmacoepi & Clinical Pharmacology"'
Autor:
Christiansen, Helle, De Bruin, Marie L, Hallgreen, Christine E, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Christiansen, H, De Bruin, M L & Hallgreen, C E 2022, ' Mandatory requirements for pediatric drug development in the EU and the US for novel drugs : A comparative study ', Frontiers in Medicine, vol. 9, 1009432 . https://doi.org/10.3389/fmed.2022.1009432
Frontiers in Medicine, 9. Frontiers Media S.A.
Frontiers in Medicine, 9. Frontiers Media S.A.
Mandatory pediatric legislation has been implemented in the European Union (EU) and the United States (US) to increase research and the availability of drugs for the pediatric population. Differences in the legislative framework can cause different p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99d45fc17f6ac3adcef2437974247a2
https://dspace.library.uu.nl/handle/1874/424448
https://dspace.library.uu.nl/handle/1874/424448
Autor:
Wang, Shirley V., Pottegård, Anton, Crown, William, Arlett, Peter, Ashcroft, Darren M., Benchimol, Eric I., Berger, Marc L., Crane, Gracy, Goettsch, Wim, Hua, Wei, Kabadi, Shaum, Kern, David M., Kurz, Xavier, Langan, Sinead, Nonaka, Takahiro, Orsini, Lucinda, Perez-Gutthann, Susana, Pinheiro, Simone, Pratt, Nicole, Schneeweiss, Sebastian, Toussi, Massoud, Williams, Rebecca J., Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Value in Health, 25(10), 1663. Elsevier Ltd
Pharmacoepidemiology and Drug Safety, 32(1), 44. John Wiley and Sons Ltd
Pharmacoepidemiology and Drug Safety, 32(1), 44. John Wiley and Sons Ltd
Refereed/Peer-reviewed Objectives: Ambiguity in communication of key study parameters limits the utility of real-world evidence (RWE) studies in healthcare decision-making. Clear communication about data provenance, design, analysis, and implementati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e5bd06878ba5830c3b0b83dca0e556
https://dspace.library.uu.nl/handle/1874/424443
https://dspace.library.uu.nl/handle/1874/424443
Autor:
Mertens, Josephine F, Koster, Ellen S, Deneer, Vera H M, Bouvy, Marcel L, van Gelder, Teun, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Currents in Pharmacy Teaching and Learning, 14(10), 1326. Elsevier
Currents in Pharmacy Teaching and Learning, 14(10), 1326-1336. ELSEVIER SCIENCE INC
Currents in Pharmacy Teaching and Learning, 14(10), 1326-1336. ELSEVIER SCIENCE INC
BACKGROUND: Clinical reasoning is considered a core competency for pharmacists, but there is a lack of conceptual clarity that complicates teaching and assessment. This scoping review was conducted to identify, map, and examine evidence on used cogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b61d302cfe6ff16fef8e99594ceac3
https://hdl.handle.net/1887/3515279
https://hdl.handle.net/1887/3515279
Autor:
Aakjaer, Mia, Werther, Sarah Kimmer, De Bruin, Marie Louise, Andersen, Morten, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Clinical and Translational Science, 15(9), 2105. Wiley-Blackwell Publishing Ltd
Aakjær, M, Werther, S K, De Bruin, M L & Andersen, M 2022, ' Serious arrhythmia in initiators of citalopram, escitalopram, and other selective serotonin reuptake inhibitors : A population-based cohort study in older adults ', Clinical and Translational Science, vol. 15, no. 9, pp. 2105-2115 . https://doi.org/10.1111/cts.13319
Aakjær, M, Werther, S K, De Bruin, M L & Andersen, M 2022, ' Serious arrhythmia in initiators of citalopram, escitalopram, and other selective serotonin reuptake inhibitors : A population-based cohort study in older adults ', Clinical and Translational Science, vol. 15, no. 9, pp. 2105-2115 . https://doi.org/10.1111/cts.13319
The selective serotonin reuptake inhibitors (SSRIs) citalopram and escitalopram are associated with QT prolongation, which increases the risk of serious arrhythmia. Consequently, regulatory agencies issued safety warnings in 2011. This study aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65986c8ac36ae43499b19daaef3f9925
https://dspace.library.uu.nl/handle/1874/424671
https://dspace.library.uu.nl/handle/1874/424671
Autor:
Dijkstra, Nienke E., Sino, Carolien G.M., Schoonhoven, Lisette, Verdoorn, Sanne, Bouvy, Marcel L., Heerdink, Eibert R., Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Journal of Interprofessional Education and Practice, 28, 1. Elsevier
Regular clinical medication reviews (CMRs) are recommended for monitoring and addressing potential drug-related problems, especially in elderly people. Interprofessional collaborative practice (ICP) by general practitioners, community pharmacists, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a15c76a928484b24189a9286935b719
https://dspace.library.uu.nl/handle/1874/424213
https://dspace.library.uu.nl/handle/1874/424213
Autor:
van de Burgt, Britt W M, Wasylewicz, Arthur T M, Dullemond, Bjorn, Grouls, Rene J E, Egberts, Toine C G, Bouwman, Arthur, Korsten, Erik M M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA, 30(3), 588. BMJ Publishing Group
ObjectiveCombining text mining (TM) and clinical decision support (CDS) could improve diagnostic and therapeutic processes in clinical practice. This review summarizes current knowledge of the TM-CDS combination in clinical practice, including their
Autor:
Adam, Ildiko, Callenbach, Marcelien, Nemeth, Bertalan, Vreman, Rick A., Ponten, Johan, Strbad, Tea, Dawoud, Dalia, Kostyuk, Alexander, Seyam, Ahmed, Nagy, Laszlo, Goettsch, Wim G., Kalo, Zoltan, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Frontiers in Medicine, 9, 1. Frontiers Media S.A.
The need for innovative payment models for health technologies with high upfront costs has emerged due to affordability concerns across the world. Early technology adopter countries have been experimenting with delayed payment schemes. Our objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dace3ff76a6de354abbea39731c0ed1
https://dspace.library.uu.nl/handle/1874/422668
https://dspace.library.uu.nl/handle/1874/422668
Autor:
Alsamil, Ali M, Giezen, Thijs J, Egberts, Toine C, Doevendans, Erik, Leufkens, Hubert G, Gardarsdottir, Helga, Afd Pharmacoepi & Clinical Pharmacology, Afd Pharmaceutics, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
European Journal of Pharmaceutical Sciences, 175, 1. Elsevier
The manufacturing of biopharmaceuticals is complex, and minor changes in the process may affect quality attributes (QAs) that may, in turn, impact clinical outcomes. Regulatory documents from the European Medicines Agency were used to characterize tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c370440ba4c27ab35c5f883169215bd
https://dspace.library.uu.nl/handle/1874/422245
https://dspace.library.uu.nl/handle/1874/422245
Autor:
Li, Wenlong, Lehutova, Daniela, Sparidans, Rolf W, Heydari, Paniz, Wang, Jing, Lebre, Maria C, Beijnen, Jos H, Schinkel, Alfred H, Afd Pharmacoepi & Clinical Pharmacology, Afd Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Pharmacology
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics, 177, 135. Elsevier
Cintirorgon (LYC-55716), a first-in-class, small-molecule, oral selective RORγ agonist, has been developed as a new immuno-oncology drug for solid tumors. We here studied the functions of the ABCB1 and ABCG2 multidrug efflux transporters, the OATP1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7d98d2e1804d34f5f1bbeb20c569f6
https://dspace.library.uu.nl/handle/1874/421926
https://dspace.library.uu.nl/handle/1874/421926
Autor:
Susam, M. Merve, Wang, Jing, Schinkel, Alfred H., Beijnen, Jos H., Sparidans, Rolf W., Afd Pharmacoepi & Clinical Pharmacology, Afd Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Pharmacology
Publikováno v:
Biomedical Chromatography, 36(11). John Wiley and Sons Ltd
EAI045 is a tyrosine kinase inhibitor (TKI) that targets the mutant epidermal growth factor receptor (EGFR). It was developed to control resistance to available EGFR TKIs. In this study, a major metabolite of EAI045, (5-fluoro-2-hydroxyphenyl)(1-oxo-