Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Masahiro Shin"'
Autor:
Craig C. Mello, Yeonsoo Yoon, Hassan Gneid, Jonathan K. Watts, Jaime A. Rivera-Pérez, Ping Xu, Pengpeng Liu, Xiao-Ou Zhang, Judith Gallant, Krishna S. Ghanta, Masahiro Shin, Nathan D. Lawson, Pranathi Meda Krishnamurthy, Ahmet R. Ozturk, Aamir Mir, Erik J. Sontheimer, Zexiang Chen, Alireza Edraki, Gregoriy A Dokshin, Feston Idrizi
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Nuclease-directed genome editing is a powerful tool for investigating physiology and has great promise as a therapeutic approach to correct mutations that cause disease. In its most precise form, genome editing can use cellular homology-directed repa
Autor:
Masahiro Shin, Nathan D. Lawson
Publikováno v:
Development, growthdifferentiation. 63(9)
Lymphatic valves develop from pre-existing endothelial cells through a step-wise process involving complex changes in cell shape and orientation, along with extracellular matrix interactions, to form two intraluminal leaflets. Once formed, valves pre
Autor:
Karina Yaniv, Ayelet Jerafi-Vider, Gideon Hen, Nathan D. Lawson, Daniel Splittstoesser, Yaara Tevet, Masahiro Shin, Ivan Bassi, Noga Moshe
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 11, Pp 109255-(2021)
Cell Reports, Vol 35, Iss 11, Pp 109255-(2021)
Summary The formation of new vessels requires a tight synchronization between proliferation, differentiation, and sprouting. However, how these processes are differentially activated, often by neighboring endothelial cells (ECs), remains unclear. Her
Autor:
Kyle Morrison, Samantha F. Kwok, Esther Mintzer, Masahiro Shin, Josias B. Frazao, Benjamin P. Roscoe, Sneha Suresh, Jeremy Luban, Feston Idrizi, Mehmet Fatih Bolukbasi, Scot A. Wolfe, Karthikeyan Ponnienselvan, Nathan D. Lawson, Lihua Julie Zhu, Pengpeng Liu, Kevin Luk
Publikováno v:
Nucleic Acids Research
Type V CRISPR–Cas12a systems provide an alternate nuclease platform to Cas9, with potential advantages for specific genome editing applications. Here we describe improvements to the Cas12a system that facilitate efficient targeted mutagenesis in ma
Autor:
Masahiro Shin, Alper Kucukural, Oliver A. Stone, Nathan D. Lawson, Onur Yukselen, Rui Li, Lihua Julie Zhu, Ann S. Grosse
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The zebrafish is ideal for studying embryogenesis and is increasingly applied to model human disease. In these contexts, RNA-sequencing (RNA-seq) provides mechanistic insights by identifying transcriptome changes between experimental conditions. Appl
Autor:
Naoki Mochizuki, Tomonori Deguchi, Feston Idrizi, Shinya Yuge, Masahiro Shin, Benjamin P. Roscoe, Kinji Ishida, Shigetomo Fukuhara, Nathan D. Lawson, Katsutoshi Ogasawara, Scot A. Wolfe, Sumio Isogai, Takayuki Nozaki
Publikováno v:
Dev Cell
Summary The lymphatic system comprises blind-ended tubes that collect interstitial fluid and return it to the circulatory system. In mammals, unidirectional lymphatic flow is driven by muscle contraction working in conjunction with valves. Accordingl
Autor:
Chih-Wen Ni, Andreas van Impel, Ankit Gupta, Ann S. Grosse, Dana F. DeSantis, Fatma O. Kok, George Kourkoulis, Nathan D. Lawson, Christer Betsholtz, Masahiro Shin, Ira Male, Bettina C. Kirchmaier, Scot A. Wolfe, Josi Peterson-Maduro, Sarah Sheppard-Tindell, Lwaki Ebarasi, Stefan Schulte-Merker
Publikováno v:
Developmental Cell, 32(1), 97. Cell Press
The widespread availability of programmable site-specific nucleases now enables targeted gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate zebrafish lines bearing individual mutations in more than 20 gene
Autor:
Ira Male, Fatma O. Kok, Lihua Julie Zhu, Masahiro Shin, Jacques A. Villefranc, Nathan D. Lawson, Timothy J. Beane
Publikováno v:
Development.
Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To better understand Flt4 signaling, we generated zeb
Autor:
Roy Hofi, Natascia Tiso, Giorgia Busolin, Lihee Asaf, Nathan D. Lawson, Julian Nicenboim, Gabriella Almog, Gideon Hen, Masahiro Shin, Karina Yaniv, Oded Mayseless
Publikováno v:
Development.
Formation and remodeling of vascular beds are complex processes orchestrated by multiple signaling pathways. While it is well accepted that vessels of a particular organ display specific features that enable them to fulfill distinct functions, the em