Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Nicholas J. Timpson"'
Autor:
Si Fang, Kaitlin H. Wade, David A. Hughes, Sophie Fitzgibbon, Vikki Yip, Nicholas J. Timpson, Laura J. Corbin
Publikováno v:
Fang, S, Wade, K H, Hughes, D A, FitzGibbon, S J, Yip, V L, Timpson, N J & Corbin, L J 2022, ' A multivariant recall-by-genotype study of the metabolomic signature of BMI ', Obesity, vol. 30, no. 6, pp. 1298-1310 . https://doi.org/10.1002/oby.23441
Obesity (Silver Spring)
Obesity (Silver Spring)
ObjectiveThis study estimated the effect of BMI on circulating metabolites in young adults using a recall-by-genotype study design.MethodsA recall-by-genotype study was implemented in the Avon Longitudinal Study of Parents and Children. Samples from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50df8cbc31269bc22693a87687e650f
https://research-information.bris.ac.uk/ws/files/327670903/Obesity_2022_Fang_A_multivariant_recall_by_genotype_study_of_the_metabolomic_signature_of_BMI_1_.pdf
https://research-information.bris.ac.uk/ws/files/327670903/Obesity_2022_Fang_A_multivariant_recall_by_genotype_study_of_the_metabolomic_signature_of_BMI_1_.pdf
Autor:
Nicholas J. Timpson, Tim T Morris, Rebecca M. Pearson, Frances Rice, Alex S. F. Kwong, Evie Stergiakouli, Kate Tilling
Publikováno v:
Kwong, A S F, Morris, T T, Pearson, R M, Timpson, N J, Rice, F, Stergiakouli, E & Tilling, K 2021, ' Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence ', Journal of Child Psychology and Psychiatry, vol. 62, no. 12, pp. 1462-1474 . https://doi.org/10.1111/jcpp.13422
Kwong, A S F, Morris, T T, Pearson, R M, Timpson, N J, Rice, F, Stergiakouli, E & Tilling, K 2021, ' Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence ', Journal of Child Psychology and Psychiatry . https://doi.org/10.1111/jcpp.13422
Kwong, A S F, Morris, T T, Pearson, R M, Timpson, N J, Rice, F, Stergiakouli, E & Tilling, K 2021, ' Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence ', Journal of Child Psychology and Psychiatry . https://doi.org/10.1111/jcpp.13422
Background\ud \ud Adolescence marks a period where depression will commonly onset. Twin studies show that genetic influences play a role in how depression develops and changes across adolescence. Recent genome‐wide association studies highlight tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3acf4d6ef1d878015c870841255df42
https://hdl.handle.net/1983/412ab6be-9aa0-4730-bdd1-a27f99eec369
https://hdl.handle.net/1983/412ab6be-9aa0-4730-bdd1-a27f99eec369
Autor:
Nicholas J. Timpson, Vikki L Yip, Kaitlin H Wade, Laura J Corbin, Si Fang, Sophie Fitzgibbon, David A. Hughes
ObjectiveWe estimated the effect of body mass index (BMI) on circulating metabolites in young adults using a recall-by-genotype (RbG) study design.MethodsAn RbG study was implemented in the Avon Longitudinal Study of Parents and Children. Samples fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb25e608633af9e2fa91170aac0d3904
https://doi.org/10.1101/2021.10.21.465319
https://doi.org/10.1101/2021.10.21.465319
Autor:
Nicholas J. Timpson, Kate Tilling, Maria Carolina Borges, Debbie A Lawlor, Gemma L. Clayton, Alba Fernández-Sanlés, Gareth J Griffith, Kate Northstone, Louise A C Millard, Alice R Carter, Daniel J. Smith
Publikováno v:
Wellcome Open Research. 6:184
Background: Longitudinal studies are crucial for identifying potential risk factors for infection with, and consequences of, COVID-19, but relationships can be biased if they are associated with invitation and response to data collection. We describe
Autor:
Xiaoming Liu, Jacek Mokrosinski, Audrey Melvin, Kara Rainbow, Sam Neaves, Alice E. Williamson, Jian-Hua Chen, Giles S.H. Yeo, Brian Y.H. Lam, David A. Hughes, Warren Pan, Chen Zhang, Kaitlin H Wade, Laura J Corbin, Katie Duckett, Alexander Mörseburg, I. Sadaf Farooqi, Stephen O'Rahilly, Nicholas J. Timpson
Publikováno v:
Wade, K H, Lam, B Y H, Melvin, A, Pan, W, Corbin, L J, Hughes, D A, Rainbow, K, Chen, J H, Duckett, K, Liu, X, Mokrosińsk, J, Mörseburg, A, Neaves, S, Williamson, A, Zhang, C, Farooqi, I S, Yeo, G S H, Timpson, N J & O'Rahilly, S 2021, ' Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort ', Nature Medicine, vol. 27, no. 6, pp. 1088-1096 . https://doi.org/10.1038/s41591-021-01349-y
Nature medicine
Nature medicine
Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We examined the MC4R coding sequence in 5,724 participants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4c6d4738901f0d30b3f6d5fc2cb7e4
https://research-information.bris.ac.uk/en/publications/b37c1c28-62cb-4d8a-b7c3-5383cde62078
https://research-information.bris.ac.uk/en/publications/b37c1c28-62cb-4d8a-b7c3-5383cde62078
Autor:
Nicholas J. Timpson, Ullrich Bartsch, Michelle L. Taylor, Charlotte Hellmich, Hugh Marston, Claire Durant, Kayleigh E Easey, Laura J Corbin, Matt Jones
Publikováno v:
Sleep
Bartsch, U, Corbin, L J, Hellmich, C, Taylor, M, Easey, K, Durant, C F, Marston, H M, Timpson, N J & Jones, M W 2021, ' Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults ', Sleep, vol. 44, no. 12, zsab191 . https://doi.org/10.1093/sleep/zsab191
Bartsch, U, Corbin, L J, Hellmich, C, Taylor, M, Easey, K, Durant, C F, Marston, H M, Timpson, N J & Jones, M W 2021, ' Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults ', Sleep, vol. 44, no. 12, zsab191 . https://doi.org/10.1093/sleep/zsab191
The rs1344706 polymorphism in ZNF804A is robustly associated with schizophrenia and schizophrenia is, in turn, associated with abnormal non-rapid eye movement (NREM) sleep neurophysiology. To examine whether rs1344706 is associated with intermediate
Identifying Critical Points of Trajectories of Depressive Symptoms from Childhood to Young Adulthood
Autor:
David Manley, Nicholas J. Timpson, George Leckie, Alex S. F. Kwong, Evie Stergiakouli, Jon Heron, Hannah M Sallis, Oliver S. P. Davis, Rebecca M. Pearson
Publikováno v:
Kwong, A, Manley, D, Timpson, N, Pearson, R, Heron, J, Sallis, H, Stergiakouli, E, Davis, O S P & Leckie, G 2019, ' Identifying Critical Points of Trajectories of Depressive Symptoms from Childhood to Young Adulthood ', Journal of Youth and Adolescence, vol. 48, no. 4, pp. 815-827 . https://doi.org/10.1007/s10964-018-0976-5
Journal of Youth and Adolescence
Journal of Youth and Adolescence
Depression is a common mental illness and research has focused on late childhood and adolescence in an attempt to prevent or reduce later psychopathology and/or social impairments. It is important to establish and study population-averaged trajectori
Autor:
Laura J. Corbin, David A. Hughes, Andrew J. Chetwynd, Amy E. Taylor, Andrew D. Southam, Andris Jankevics, Ralf J. M. Weber, Alix Groom, Warwick B. Dunn, Nicholas J. Timpson
Publikováno v:
Metabolomics
High plasma triacylglyceride levels are known to be associated with increased risk of atherosclerotic cardiovascular disease. Apolipoprotein C-III (apoC-III) is a key regulator of plasma triacylglyceride levels and is associated with hypertriglycerid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a378fb951fbc26737d7dcca773f4950
https://europepmc.org/articles/PMC7919761/
https://europepmc.org/articles/PMC7919761/
Autor:
Kaitlin H, Wade, Brian Y H, Lam, Audrey, Melvin, Warren, Pan, Laura J, Corbin, David A, Hughes, Kara, Rainbow, Jian-Hua, Chen, Katie, Duckett, Xiaoming, Liu, Jacek, Mokrosiński, Alexander, Mörseburg, Sam, Neaves, Alice, Williamson, Chen, Zhang, I Sadaf, Farooqi, Giles S H, Yeo, Nicholas J, Timpson, Stephen, O'Rahilly
Publikováno v:
Nature medicine. 27(6)
Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We examined the MC4R coding sequence in 5,724 participants
Autor:
Inês Barroso, Peter D. Sly, Jose Ramon Bilbao, Nicholas J. Timpson, Johan G. Eriksson, Maria M. Groen-Blokhuis, Sijmen A. Reijneveld, Dariusz Gruszfeld, George Davey Smith, Christine Power, Eva Reischl, Mandy Vogel, Andrew T. Hattersley, Øyvind Helgeland, Niina Pitkänen, Akram Alyass, Jean-Paul Langhendries, Elina Hyppönen, Kathrin Landgraf, Loreto Santa-Marina, Frank Geller, Christopher D. Brown, Elvira Verduci, Katja Pahkala, Olli T. Raitakari, Joaquin Escribano, Torben Hansen, Hakon Hakonarson, Barbara Heude, Bridget A. Knight, Maties Torrent, Robin N Beaumont, Judith M. Vonk, Estelle Lowry, Patrick G. Holt, Harold Snieder, Carol A. Wang, Mark I. McCarthy, Christine Frithioff-Bøjsøe, Tanja G. M. Vrijkotte, Natalia Vilor-Tejedor, Lisbeth Carstensen, Catharina E. M. van Beijsterveldt, Ville Karhunen, Virpi Lindi, Marjo-Riitta Järvelin, Tarunveer S. Ahluwalia, Jordi Sunyer, Jaakko T. Leinonen, Clare S. Murray, Klaus Bønnelykke, Thorkild I. A. Sørensen, André G. Uitterlinden, Janine F. Felix, John A. Curtin, Mika Kähönen, Jorma Viikari, Leo-Pekka Lyytikäinen, Oluf Pedersen, Carmen Iñiguez, Harri Niinikoski, Wieland Kiess, Kim F. Michaelsen, Evie Stergiakouli, Anni Heiskala, Alessandra Chesi, Craig E. Pennell, Mohammed H Zafarmand, Peter Rzehak, Kook K Teo, Aihuali Li, Marie Standl, Veit Grote, Momoko Horikoshi, Ellen A. Nohr, Eleanor Wheeler, Rachel M. Freathy, Iryna O. Fedko, Gerard H. Koppelman, Elisabeth Widen, Jens-Christian Holm, Raimo Joro, David Meyre, Mustafa Atalay, Theresia M. Schnurr, Camilla Schmidt Morgen, Adnan Custovic, Niels Grarup, Trevor A. Mori, Terho Lehtimäki, Christian Theil Have, Angela Simpson, Mads Melbye, Bjarke Feenstra, Lawrence J. Beilin, Stefan Johansson, Ioanna Ntalla, Martine Vrijheid, Mariona Bustamante, George Dedoussis, Sylvain Sebert, Jonas Bacelis, Carolina Medina-Gomez, Elisabeth Thiering, Ken K. Ong, Eleftheria Zeggini, Berthold Koletzko, Karine Clément, Bo L. Chawes, Mette Hollensted, Babette S. Zemel, Markus Scholz, Holger Kirsten, Antje Körner, Albertine J. Oldehinkel, Barbera D. C. van Schaik, Philippe Froguel, Vincent W. V. Jaddoe, Dorret I. Boomsma, Struan F.A. Grant, Loic Yengo, Jonathan P. Bradfield, Tenna Ruest Haarmark Nielsen, Suzanne Vogelezang, Jakob Stokholm, Pål R. Njølstad, Bo Jacobsson, Marc Vaudel, Peter J. van der Most, Andreas Kühnapfel, Mads Vendelbo Lind, Timo A. Lakka, Saskia Selzam, Robert Plomin, Marie-Aline Charles, Jouke-Jan Hottenga, Kalliope Panoutsopoulou, Fernando Rivadeneira, Rebecca K. Vinding, Hans Bisgaard, I. S. Farooqi, Joachim Heinrich, Diana L. Cousminer, Ricardo Closa-Monasterolo, Claire Monnereau
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1008718 (2020)
PLoS Genetics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Grarup, N, Schnurr, T M, Hansen, T, Michaelsen, K F, Pedersen, O B, Stokholm, J, Lind, M V, Frithioff-Bøjsøe, C, Holm, J-C, Felix, J F & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', P L o S Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Lakka, T A, Grarup, N, Scholz, M, van der Most, P J, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, I O, Vilor-Tejedor, N, Cousminer, D L, Standl, M, Wang, C A, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, J M, Zafarmand, M H, Heude, B, Farooqi, I S, Alyass, A, Beaumont, R N, Have, C T, Rzehak, P, Bilbao, J R, Schnurr, T M, Barroso, I, Bønnelykke, K, Beilin, L J, Carstensen, L, Charles, M A, Chawes, B, Clément, K, Closa-Monasterolo, R, Custovic, A, Hansen, T, Morgen, C S, Nohr, E A & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLOS Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
PLOS Genetics
PLoS Genetics (online), 16(10):e1008718. Public Library of Science
PLoS genetics, 16(10):e1008718. Public Library of Science
PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
e1008718
PLOS GENETICS
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Fedko, I O, Groen-Blokhuis, M, Hottenga, J-J, Van Beijsterveldt, C E M, Vrijkotte, T G M, Boomsma, D I & Early Growth Genetics (EGG) Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLoS Genetics, vol. 16, no. 10, e1008718, pp. 1-26 . https://doi.org/10.1371/journal.pgen.1008718
PLoS Genetics, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
PLoS Genetics, 16(10):e1008718, 1-26. Public Library of Science
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
r-FISABIO. Repositorio Institucional de Producción Científica
Curtin, J, Murray, C & et al. 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PL o S Genetics . https://doi.org/10.1371/journal.pgen.1008718
PLoS genetics, 16(10):e1008718. PUBLIC LIBRARY SCIENCE
PLoS Genet. 16:e1008718 (2020)
PLoS Genetics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Grarup, N, Schnurr, T M, Hansen, T, Michaelsen, K F, Pedersen, O B, Stokholm, J, Lind, M V, Frithioff-Bøjsøe, C, Holm, J-C, Felix, J F & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', P L o S Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Lakka, T A, Grarup, N, Scholz, M, van der Most, P J, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, I O, Vilor-Tejedor, N, Cousminer, D L, Standl, M, Wang, C A, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, J M, Zafarmand, M H, Heude, B, Farooqi, I S, Alyass, A, Beaumont, R N, Have, C T, Rzehak, P, Bilbao, J R, Schnurr, T M, Barroso, I, Bønnelykke, K, Beilin, L J, Carstensen, L, Charles, M A, Chawes, B, Clément, K, Closa-Monasterolo, R, Custovic, A, Hansen, T, Morgen, C S, Nohr, E A & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLOS Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
PLOS Genetics
PLoS Genetics (online), 16(10):e1008718. Public Library of Science
PLoS genetics, 16(10):e1008718. Public Library of Science
PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
e1008718
PLOS GENETICS
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Fedko, I O, Groen-Blokhuis, M, Hottenga, J-J, Van Beijsterveldt, C E M, Vrijkotte, T G M, Boomsma, D I & Early Growth Genetics (EGG) Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLoS Genetics, vol. 16, no. 10, e1008718, pp. 1-26 . https://doi.org/10.1371/journal.pgen.1008718
PLoS Genetics, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
PLoS Genetics, 16(10):e1008718, 1-26. Public Library of Science
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
r-FISABIO. Repositorio Institucional de Producción Científica
Curtin, J, Murray, C & et al. 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PL o S Genetics . https://doi.org/10.1371/journal.pgen.1008718
PLoS genetics, 16(10):e1008718. PUBLIC LIBRARY SCIENCE
PLoS Genet. 16:e1008718 (2020)
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association s