Zobrazeno 1 - 10
of 29
pro vyhledávání: '"George Kemble"'
Autor:
Ann B. Hill, George Kemble, Michael A. McVoy, Pavlo A. Nesterenko, Stanley A. Plotkin, Anne Marie Manganello, Josephine H. Cox, Ronzo Lee, Daniel E. Nixon, Edward S. Mocarski, Stuart P. Adler, Patricia E. Fast, Susan E. Murray
Publikováno v:
Journal of Infectious Diseases. 214:1341-1348
Background Human cytomegalovirus (HCMV) infection causes disease in newborns and transplant recipients. A HCMV vaccine (Towne) protects transplant recipients. Methods The genomes of Towne and the nonattenuated Toledo strain were recombined, yielding
Publikováno v:
Journal of Virology. 84:7695-7702
H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pandemic influenza virus vaccine ca
Autor:
Laura Gillim-Ross, Hong Jin, George Kemble, Zhongying Chen, Kanta Subbarao, Celia Santos, Amy Aspelund
Publikováno v:
Journal of Virology. 83:65-72
Avian influenza A virus A/teal/HK/W312/97 (H6N1) possesses seven gene segments that are highly homologous to those of highly pathogenic human influenza H5N1 viruses, suggesting that a W312-like H6N1 virus might have been involved in the generation of
Autor:
Zhongying Chen, Amy Aspelund, Hong Jin, Celia Santos, Laura Gillim-Ross, Kanta Subbarao, Dan Ye, Chin-Fen Yang, George Kemble
Publikováno v:
Journal of Virology. 82:10854-10863
Influenza pandemic preparedness has focused on influenza virus H5 and H7 subtypes. However, it is not possible to predict with certainty which subtype of avian influenza virus will cause the next pandemic, and it is prudent to include other avian inf
Autor:
Leatrice Vogel, George Kemble, Josephine M. McAuliffe, Bin Lu, Tomy Joseph, Hong Jin, Kanta Subbarao, David E. Swayne
Publikováno v:
Virology. 378(1):123-132
The appearance of human infections caused by avian influenza A H7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated
Evaluation of Replication and Pathogenicity of Avian Influenza A H7 Subtype Viruses in a Mouse Model
Publikováno v:
Journal of Virology. 81:10558-10566
Avian influenza A H7 subtype viruses pose a significant threat to human health because of their ability to transmit directly from domestic poultry to humans and to cause disease and, sometimes, death. Although it is important to develop vaccines agai
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144648 (2015)
PLoS ONE, Vol 10, Iss 12, p e0144648 (2015)
Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a fatty acid utilized for synthesis of more complex fatty acids, plasma membrane structure, and post-translational palmitoylation of host and viral proteins. We have developed a
Autor:
George Kemble, Thomas C. Heineman, Ann M. Arvin, Margaret Sharp, Cornelia L. Dekker, Nicola P. Klein, Tyson H. Holmes, Mark R. Schleiss, David I. Bernstein
Publikováno v:
Vaccine. 24:5913-5918
Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specifi
Publikováno v:
International Congress Series. 1263:153-156
The genetic basis for the attenuation ( att ) and temperature sensitive ( ts ) phenotypes of the cold-adapted A/Ann Arbor/6/60 influenza virus, the master donor virus for the influenza A (MDV-A) FluMist™ vaccine, was mapped to the PB1, PB2 and NP g
Publikováno v:
International Congress Series. 1263:439-443
To investigate the possibility of using influenza virus as a vaccine vector, two different NS1 recombinants were constructed via plasmid rescue from A/PR/8/34. (1) Green fluorescent protein (GFP) was fused with the first 130 amino acids of the NS1 op