Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Manabu, Igarashi"'
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Autor:
Shiho Torii, Tsogtbaatar Urangoo, Keita Matsuno, Yoshihiro Takadate, Khanui Buyantogtokh, Takeshi Saito, Kosuke Okuya, Ankhanbaatar Ulaankhuu, Khishgee Bodisaikhan, Takanari Hattori, Masatoshi Okamatsu, Manabu Igarashi, Yoshihiro Sakoda, Jargalsaikhan Tserenjav, Damdinjav Batchuluun, Yurie Kida, Hiroshi Kida, Mao Isono, Junki Maruyama, Tsolmon Amartuvshin, Masahiro Sato, Enkhbold Bazarragchaa, Takahiro Hiono, Ayato Takada, Tatsunari Kondoh, Nodoka Kasajima
Publikováno v:
Virus Genes
The circulation of highly pathogenic avian influenza viruses (HPAIVs) of various subtypes (e.g., H5N1, H5N6, H5N8, and H7N9) in poultry remains a global concern for animal and public health. Migratory waterfowls play important roles in the transmissi
Autor:
Taksoo Kim, Manabu Igarashi, Shizuka Hirose, Norikazu Isoda, Yoshihiro Sakoda, Loc Tan Huynh, Takahiro Hiono
Publikováno v:
Viruses, Vol 13, Iss 1672, p 1672 (2021)
Viruses
Volume 13
Issue 8
Viruses
Volume 13
Issue 8
The GPE− strain is a live attenuated vaccine for classical swine fever (CSF) developed in Japan. In the context of increasing attention for the differentiating infected from vaccinated animals (DIVA) concept, the achievement of CSF eradication with
Publikováno v:
PeerJ
PeerJ, Vol 9, p e11552 (2021)
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Autor:
Takeshi Saito, Yoshihiro Takadate, Rashid Manzoor, Hiroko Miyamoto, Manabu Igarashi, Ayato Takada, Yurie Kida, Hirohito Ogawa, Junki Maruyama, Masahiro Kajihara, Tatsunari Kondoh
Publikováno v:
Microorganisms, Vol 8, Iss 1530, p 1530 (2020)
Microorganisms
Volume 8
Issue 10
Microorganisms
Volume 8
Issue 10
Lloviu virus (LLOV), a bat-derived filovirus that is phylogenetically distinct from human pathogenic filoviruses such as Ebola virus (EBOV) and Marburg virus (MARV), was discovered in Europe. However, since infectious LLOV has never been isolated, th
Publikováno v:
Viruses
Volume 13
Issue 5
Viruses, Vol 13, Iss 913, p 913 (2021)
Volume 13
Issue 5
Viruses, Vol 13, Iss 913, p 913 (2021)
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to th
Autor:
Kumiko Yoshimatsu, Sanae Nishio, Manabu Igarashi, Kenta Shimizu, Ryo Ito, Yoshimi Tsuda, Jiro Arikawa
Publikováno v:
Biomedical Research. 38:89-97
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus responsible for causing an emerging zoonotic disease. We previously established subclones from SFTSV strain YG1 based on differences in low-pH-dependent cell fusion acti
Autor:
Shohei Kojima, Ryo Sato, Manabu Igarashi, Masayuki Horie, Yumiko Komatsu, Mako Yanai, Keizo Tomonaga
Publikováno v:
Journal of Virology. 93
Targeting of viral proteins to specific subcellular compartments is a fundamental step for viruses to achieve successful replication in infected cells. Borna disease virus 1 (BoDV-1), a nonsegmented, negative-strand RNA virus, uniquely replicates and
Autor:
Manabu Igarashi
Publikováno v:
YAKUGAKU ZASSHI. 135:1015-1021
For the prevention and control of infectious viral diseases, vaccines and antiviral drugs targeting viral proteins are of great importance. Amino acid substitutions in viral proteins occasionally cause the emergence of antibody-escape and drug-resist
Autor:
Shinichiro Nakamura, Yasushi Itoh, Misako Nakayama, Kazumasa Ogasawara, Masatoshi Okamatsu, Michiko Doi, Masanori Shiohara, Hiroshi Kida, Yoshihiro Sakoda, Hideaki Ishida, Hirohito Ishigaki, Akihiro Ishii, Naoko Kitagawa, Hideaki Tsuchiya, Manabu Igarashi, Shintaro Shichinohe, Takako Sasamura
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:4962-4973
The number of patients infected with H7N9 influenza virus has been increasing since 2013. We examined the efficacy of neuraminidase (NA) inhibitors and the efficacy of a vaccine against an H7N9 influenza virus, A/Anhui/1/2013 (H7N9), isolated from a