Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yuqiong Liang"'
Publikováno v:
Proceedings of the National Academy of Sciences. 104:7253-7258
Mitochondrial antiviral signaling protein (MAVS) is an essential component of virus-activated signaling pathways that induce protective IFN responses. Its localization to the outer mitochondrial membrane suggests an important yet unexplained role for
Autor:
Daisuke Yamane, Zongdi Feng, Kui Li, Stanley M. Lemon, Lin Qu, Robert E. Lanford, Yuqiong Liang
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002169 (2011)
PLoS Pathogens
PLoS Pathogens
Toll-like receptor 3 (TLR3) and cytosolic RIG-I-like helicases (RIG-I and MDA5) sense viral RNAs and activate innate immune signaling pathways that induce expression of interferon (IFN) through specific adaptor proteins, TIR domain-containing adaptor
Publikováno v:
Journal of virology. 83(19)
Toll-like receptor-3 (TLR3) senses double-stranded RNA, initiating signaling that activates NF-κB and interferon regulatory factor 3 (IRF-3), thereby inducing the synthesis of proinflammatory cytokines, type I interferons, and numerous interferon-st
Publikováno v:
Journal of virology. 82(15)
A mutation within subdomain 1 of the hepatitis C virus (HCV) NS3 helicase (NS3-Q221L) (M. Yi, Y. Ma, J. Yates, and S. M. Lemon, J. Virol. 81:629-638, 2007) rescues a defect in production of infectious virus by an intergenotypic chimeric RNA (HJ3). Al
Autor:
Min Kyung Yi, Oliver Lenz, Kenny Simmen, Tse I. Lin, Stanley M. Lemon, Richard B. Pyles, Yuqiong Liang, Nigel Bourne, Hisashi Ishida, Kui Li, Origène Nyanguile
Publikováno v:
Gastroenterology. 135(5)
Background & Aims Expression of the nonstructural protein (NS)3/4A protease in cells infected with hepatitis C virus (HCV) results in cleavage of the mitochondrial antiviral-signaling protein (MAVS) and disruption of signaling pathways that lead to v
Autor:
Jon M. Huibregtse, Yuqiong Liang, Seungtaek Kim, Stanley M. Lemon, Tsubasa Munakata, Akio Nomoto, David R. McGivern
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 3, Iss 9, Pp 1335-1347 (2007)
PLoS Pathogens, Vol 3, Iss 9, Pp 1335-1347 (2007)
Hepatitis C virus (HCV) is a positive-strand RNA virus that frequently causes persistent infections and is uniquely associated with the development of hepatocellular carcinoma. While the mechanism(s) by which the virus promotes cancer are poorly defi
Autor:
Michael R. Holbrook, Lai Wei, Zhi Zhou, Kui Li, Rene Rijnbrand, Nan Wang, Stanley M. Lemon, Qingming Dong, Yuqiong Liang, Sara E. Woodson, Joan E. Nichols, Ju-Tao Guo, Jie Wang
Publikováno v:
Virology
ISG20 is an interferon-inducible 3′–5′ exonuclease that inhibits replication of several human and animal RNA viruses. However, the specificities of ISG20's antiviral action remain poorly defined. Here we determine the impact of ectopic expressi