Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Thomas Lehner"'
Autor:
Fan Zhang, Ruiting Li, Qing Yang, Thomas Lehner, Enxiang Pan, Yizi He, Caijun Sun, Pingchao Li, Fengling Feng, Chunxiu Wu, Ling Chen, Huachun Zou, Fengyu Hu, Liqiang Feng, Jin Zhao, Weiping Cai, Linghua Li
Publikováno v:
Advanced Science
Yang, Q, Feng, F, Li, P, Pan, E, Wu, C, He, Y, Zhang, F, Zhao, J, Li, R, Feng, L, Hu, F, Li, L, Zou, H, Cai, W, Lehner, T, Sun, C & Chen, L 2019, ' Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques ', Advanced Science, vol. 6, no. 13, 1900319, pp. 3-10 . https://doi.org/10.1002/advs.201900319
Advanced Science, Vol 6, Iss 13, Pp n/a-n/a (2019)
Yang, Q, Feng, F, Li, P, Pan, E, Wu, C, He, Y, Zhang, F, Zhao, J, Li, R, Feng, L, Hu, F, Li, L, Zou, H, Cai, W, Lehner, T, Sun, C & Chen, L 2019, ' Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques ', Advanced Science, vol. 6, no. 13, 1900319, pp. 3-10 . https://doi.org/10.1002/advs.201900319
Advanced Science, Vol 6, Iss 13, Pp n/a-n/a (2019)
The latent viral reservoir is the source of viral rebound after interruption of antiretroviral therapy (ART) and is the major obstacle in eradicating the latent human immunodeficiency virus‐1 (HIV‐1). In this study, arsenic class of mineral, arse
Autor:
Robin J. Shattock, Mahavir Singh, Kaboutar Babaahmady, Zhiming Huo, Thomas Lehner, Yufei Wang, Durdana Rahman, Raphaela Giemza, David J. M. Lewis
Publikováno v:
Journal of Virology. 88:11648-11657
The international effort to prevent HIV-1 infection by vaccination has failed to develop an effective vaccine. The aim of this vaccine trial in women was to administer by the vaginal mucosal route a vaccine consisting of HIV-1 gp140 linked to the cha
Autor:
Mahavir Singh, Lesley A. Bergmeier, Jørgen Schøller, Durdana Rahman, J. Pido-Lopez, Thomas Lehner, Trevor Whittall, Katja Brunstedt, Yufei Wang
Publikováno v:
Journal of Immunological Methods. 360:1-9
The objective of this study was to produce and evaluate the immunogenic potential of a recombinant HLA-class I antigen linked to dextran. The HLA-A*0201 heavy chain and β2 microglobulin were cloned by PCR amplification of overlapping oligonucleotide
Autor:
Thomas Lehner, Charles Kelly, Lesley A. Bergmeier, Kaboutar Babaahmady, J. Pido-Lopez, Kate J. Heesom
Publikováno v:
Immunology. 129:506-515
This study is based on the evidence that immunization of macaques with human CD4(+) T cells elicits prevention of simian immunodeficiency virus (SIV) infection. We hypothesized that heat-shock protein 70 (HSP70) isolated from CD4(+) T cells may act a
Publikováno v:
AIDS. 22:1267-1276
Objective: To elicit broadly neutralizing antibody activity by combining polyclonal human serum IgG antibodies with HIVgp 1 20, human leukocyte antigen (HLA) class I or class II and 70kDa heat shock protein. Design: In addition to HIV antigens, HIV-1
Autor:
Lesley A. Bergmeier, Yufei Wang, Thomas Lehner, Trevor Whittall, Kaboutar Babaahmady, J. Pido-Lopez
Publikováno v:
Vaccine. 26:2997-3001
Summary Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission
Autor:
Thomas Lehner
Publikováno v:
Vaccine. 21:S68-S76
Control of the HIV pandemic requires an effective vaccine. The difficulties in developing a preventive vaccine are generally believed to be due to the rapid rate of mutation of HIV that escapes cytotoxic lymphocytes (CTL) and the problems in inductio
Publikováno v:
Oral Diseases. 8:63-68
The need for an effective vaccine against HIV has prompted a refocusing of attention on mucosal immunity. More than 75% of all infections are acquired across a mucosal surface. It is therefore a prerequisite for a vaccineto target directly the mucosa
Autor:
Thomas Lehner
Publikováno v:
Trends in Immunology. 23:347-351
HIV infection is transmitted predominantly through mucosal tissues that favour strains of HIV-1 that use CCR5. A lack of cell-surface expression of CCR5 found in the homozygous Δ32 CCR5 mutation, upregulation of CC chemokines and antibodies to CCR5