Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leiliang Zhang"'
Publikováno v:
Microbiology and Immunology. 64:574-577
Previously, it was found that the hepatitis C virus NS5A interacted with ACBD3 in a genotype-dependent manner. However, the region in NS5A responsible for association with ACBD3 is not clear. Domain I of NS5A was identified as critical for ACBD3 bind
Publikováno v:
Nucleic Acids Research
Zika virus is a positive single-strand RNA virus whose replication involved RNA unwinding and synthesis. ZIKV NS3 contains a helicase domain, but its enzymatic activity is not fully characterized. Here, we established a dsRNA unwinding assay based on
Publikováno v:
Virologica Sinica. 33:205-208
NAP1L1 has been shown to function in the life cycle of several DNA virus and retrovirus. However, whether NAP1L1 regulates hepatitis C virus (HCV), a positive-stranded RNA virus, remain to be elucidated. In this study, we identified NAP1L1 as a novel
Publikováno v:
Biochemical and Biophysical Research Communications
Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. Although the protein-protein interactions (PPIs) between nonstructural proteins of CHIKV have been extensively established, the complete CHIKV in
Publikováno v:
Journal of Virology. 93
Chikungunya virus (CHIKV) is transmitted to people by mosquitoes, and CHIKV infection causes fever and joint pain. Fatty acid synthase (FASN) has been identified as a proviral factor for CHIKV. How FASN participates in CHIKV replication remains to be
Autor:
Cheng-Feng Qin, Dongrong Yi, Jing An, Leiliang Zhang, Fengwen Xu, Yongxin Zhang, Jinming Zhou, Zhenlong Liu, Fei Guo, Kavita Raniga, Shan Cen, Xiaoyu Li, Ni An, Chen Liang, Jing Wang, Quanjie Li, Rui Zhou
Publikováno v:
Journal of Virology. 93
Type I interferon (IFN) inhibits viruses by inducing the expression of antiviral proteins. The IFN-induced myxovirus resistance B (MxB) protein has been reported to inhibit a limited number of viruses, including HIV-1 and herpesviruses, but its antiv
Autor:
Guangbo Yang, Guozhong Gong, Xinqiang Xiao, Feng Peng, Raymond T. Chung, Du Cheng, Lei Zhao, Leiliang Zhang, Yi Tian
Publikováno v:
Liver International. 35:1682-1691
Background & Aims Decreased levels of phosphatase and tensin homologue (PTEN) are associated with hepatocellular carcinoma (HCC) pathogenesis and poor prognosis in hepatitis C virus (HCV)-infected HCC patients. The molecular processes governing the r
Publikováno v:
The Journal of General Virology
Growth arrest and DNA-damage-inducible gene 45-α (GADD45α) protein has been shown to be a tumour suppressor and is implicated in cell-cycle arrest and suppression of cell growth. The hepatitis C virus (HCV) non-structural 5A (NS5A) protein plays an
Autor:
Gavin Ka Yu Siu, Fan Zhou, Hsiao Chang Chan, Mei Kuen Yu, Leiliang Zhang, Tuanlao Wang, Yongheng Liang, Yangchao Chen, Sidney Yu
Publikováno v:
Scientific Reports
Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the n
Autor:
Raymond T. Chung, Dahlene N. Fusco, Wenyu Lin, Du Cheng, Hong Zhao, Esperance A. Schaefer, Kaku Goto, Niwat Maneekarn, Amornrat O'Brien, Pattranuch Chusri, Lee F. Peng, Lei Zhao, Kattareeya Kumthip, Chansom Pantip, Satawat Thongsawat, Nikolaus Jilg, Leiliang Zhang
Publikováno v:
Journal of Virology. 86:8581-8591
Responses to alpha interferon (IFN-α)-based treatment are dependent on both host and viral factors and vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients infected with GT3 viruses consistently resp