Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gerlinde Obermoser"'
Autor:
Karolina Palucka, Randy A. Albrecht, Adolfo García-Sastre, Mark M. Davis, Gerlinde Obermoser, Jacques Banchereau, Dongxia Lin, Holden T. Maecker, Priyanka B. Subrahmanyam, Virginia Pascual, Tyson H. Holmes, Laura F. Su
Publikováno v:
ImmunoHorizons
The antiviral response to influenza virus is complex and multifaceted, involving many immune cell subsets. There is an urgent need to understand the role of CD4+ T cells, which orchestrate an effective antiviral response, to improve vaccine design st
Autor:
Thomas J. Scriba, Erin W. Meermeier, Hennie Geldenhuys, Anele Gela, Elisa Nemes, Gerlinde Obermoser, W. Henry Boom, John L. Johnson, Munyaradzi Musvosvi, Christiaan Hopley, Asma Toefy, Willem A. Hanekom, Ashley Veldsman, Huang Huang, David M. Lewinsohn, Melissa Murphy, Sara Suliman, Nicole Bilek, Mark Hatherill
Publikováno v:
The Journal of Immunology Author Choice
Journal of immunology (Baltimore, Md. : 1950), vol 203, iss 11
Journal of immunology (Baltimore, Md. : 1950), vol 203, iss 11
Key Points MAIT cells comprise half the CD8 T cell IFN-γ response to BCG in blood. Frequencies of MAIT cells were not sustainably modulated by BCG vaccination. Innate cytokines mediate BCG-induced MAIT cell responses in whole blood.
Tuberculosi
Tuberculosi
Autor:
Giorgio Napolitani, M K Verheul, Deborah L Cross, Irina Mohorianu, Jennifer Hill, Holden T. Maecker, Celina Jin, Joshua S Starr, Gerlinde Obermoser, Elizabeth Jones, Andrew J. Pollard, Michael D. Leipold, Christoph J. Blohmke
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Vi-polysaccharide conjugate vaccines are efficacious against cases of typhoid fever; however, an absolute correlate of protection is not established. In this study, we investigated the leukocyte response to a Vi-tetanus toxoid conjugate vaccine (Vi-T
Autor:
Mark M. Davis, Damien Chaussabel, David A. Hafler, Susan M. Kaech, Jacob Frelinger, Yuri Kotliarov, Damian Fermin, Evan Henrich, Raphael Gottardo, A. Karolina Palucka, Albert C. Shaw, Purvesh Khatri, Ruth R. Montgomery, Kenneth Stuart, Jean H. Wilson, John S. Tsang, Robert B. Belshe, Heidi J Zapata, Nicole Baldwin, Subhasis Mohanty, Renaud Gaujoux, Samit R Joshi, Ellis L. Reinherz, Barbara Siconolfi, G.A. Poland, Renan Sauteraud, Jeanine Baisch, Diane E. Grill, Bali Pulendran, Hailong Meng, Richard B. Kennedy, Gerlinde Obermoser, Virginia Pascual, Ikuyo Ueda, Esperanza Anguiano, Tamara P. Blevins, Ann L. Oberg, Erol Fikrig, Steven H. Kleinstein, Foo Cheung, Stefan Avey, Sui Tsang, Francesco Vallania, Inna G. Ovsyannikova, Shai S. Shen-Orr
Publikováno v:
Science Immunology. 2
Annual influenza vaccinations are currently recommended for all individuals 6 months and older. Antibodies induced by vaccination are an important mechanism of protection against infection. Despite the overall public health success of influenza vacci
Autor:
David Anderson, Kelly Domico, Lu Ann Thompson-Snipes, Gerlinde Obermoser, Jacques Banchereau, Derek Blankenship, Emily Ruchaud, Hui Xu, Gerald T. Nepom, Mamta Sharma, Phuong Nguyen, Alma Cepika, Damien Chaussabel, Brad Zeitner, Quynh Anh Nguyen, Hélène Dutartre, Karolina Palucka, Yuanyuan Wang, A. Carson Harrod, Sandra Zurawski, Hideki Ueno, Virginia Pascual, Scott R. Presnell, Jason A. Skinner, Elisabeth Israelsson, Charlie Quinn, Rajaram Ranganathan, Cate Speake, Anna Bjork, Esperanza Anguiano, Laia Alsina
Publikováno v:
Immunity
Immunity, Elsevier, 2013, 38 (4), pp.831-844. ⟨10.1016/j.immuni.2012.12.008⟩
Immunity, 2013, 38 (4), pp.831-844. ⟨10.1016/j.immuni.2012.12.008⟩
Immunity, Elsevier, 2013, 38 (4), pp.831-844. ⟨10.1016/j.immuni.2012.12.008⟩
Immunity, 2013, 38 (4), pp.831-844. ⟨10.1016/j.immuni.2012.12.008⟩
SummarySystems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points
Autor:
Adolfo García-Sastre, Hideki Ueno, Gerlinde Obermoser, A. Karolina Palucka, Hana Golding, Parvathi Kurup, Salah Eddine Bentebibel, Randy A. Albrecht, Nathalie Schmitt, Surender Khurana, Cynthia Mueller
Publikováno v:
Scientific Reports
The immune mechanism leading to the generation of protective antibody responses following influenza trivalent inactivated vaccine (TIV) vaccinations remains largely uncharacterized. We recently reported that TIV vaccination induced a transient increa
Autor:
John S. Tsang, Pamela L. Schwartzberg, Yuri Kotliarov, Angelique Biancotto, Zhi Xie, Ronald N. Germain, Ena Wang, Matthew J. Olnes, Manikandan Narayanan, Hana Golding, Susan Moir, Howard B. Dickler, Shira Perl, Foo Cheung, Gerlinde Obermoser, Damien Chaussabel, Karolina Palucka, Jinguo Chen, J. Christopher Fuchs, Jason Ho, Surender Khurana, Lisa R. King, Marc Langweiler, Hui Liu, Jody Manischewitz, Zoltan Pos, Jacqueline G. Posada, Paula Schum, Rongye Shi, Janet Valdez, Wei Wang, Huizhi Zhou, Daniel L. Kastner, Francesco M. Marincola, J. Philip McCoy, Giorgio Trinchieri, Neal S. Young
Publikováno v:
Cell. 158(1)
SummaryA major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires the collection of dense measurements of system states, yet transformation of data into predictive
Autor:
Damien Chaussabel, Abhilasha Cheruku, Chun I. Yu, Hui Xu, Ingrid Gayet, Karolina Palucka, Gerlinde Obermoser, Jacques Banchereau, Isabelle Berthier, Nicole Baldwin, Yaming Xue, Romain Banchereau, Shruti Athale, Sangkon Oh, Octavio Ramilo, Alma-Martina Cepika, Virginia Pascual, Derek Blankenship, Marina Ohouo, Lu Ann Snipes, Yuanyuan Wang, Patrick Metang
Publikováno v:
Nature Communications
The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Exposure of DCs to influenza, Salmonella ent
Autor:
Raquel Giacomelli Cao, Santiago Lopez, Derek Blankenship, Asuncion Mejias, Sara Mertz, Karolina Palucka, Octavio Ramilo, Randy A. Albrecht, Hui Xu, Gerlinde Obermoser, Nicolás M. Suárez, Emilio Flaño, Adolfo García-Sastre, Huanying Qin, Virginia Pascual
Publikováno v:
The Journal of infectious diseases. 210(2)
Background. Live attenuated influenza vaccine (LAIV) and trivalent inactivated influenza vaccine (TIV) are effective for prevention of influenza virus infection in children, but the mechanisms associated with protection are not well defined. Methods.